Association of correlates of endogenous hormonal exposure with breast cancer risk in 426 families (United States)

Dawn M. Grabrick, Robert A. Vierkant, Kristin E. Anderson, James R Cerhan, V. Elving Anderson, Thomas A. Sellers

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: Women with a strong family history of breast cancer are at significantly increased risk of developing the disease. There is emerging evidence that certain reproductive factors may further elevate risk in these women. We examined whether a family history of breast cancer modifies the association between correlates of endogenous hormonal exposures and breast cancer in a study of 426 families ascertained through breast cancer probands. Methods: Analyses of reproductive factors and breast cancer were performed on 395 sisters and daughters of probands, 3014 nieces and granddaughters, and 2768 marry-ins. Results: Through 226,266 person-years of follow-up since 1952, 240 women developed breast cancer. No statistically significant interactions were observed between relationship to proband and age at menarche, age at menopause, other characteristics of the menstrual cycle, parity, age at first and last birth, infertility, and total ovulatory years. Conclusions: Our findings suggest that most reproductive factors influence breast cancer risk similarly in women with and without a family history of breast cancer. Further studies are needed on individuals who are more homogeneous with regard to hereditary background. However, other options for prevention, such as prophylactic surgery or chemoprevention, may be necessary to have a substantial impact on risk reduction in women at high genetic risk.

Original languageEnglish (US)
Pages (from-to)333-341
Number of pages9
JournalCancer Causes and Control
Volume13
Issue number4
DOIs
StatePublished - 2002

Fingerprint

Breast Neoplasms
Menarche
Birth Order
Chemoprevention
Risk Reduction Behavior
Menstrual Cycle
Menopause
Parity
Nuclear Family
Infertility
Statistical Factor Analysis
Siblings

Keywords

  • Breast neoplasms
  • Epidemiology
  • Pedigree
  • Reproductive history
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Association of correlates of endogenous hormonal exposure with breast cancer risk in 426 families (United States). / Grabrick, Dawn M.; Vierkant, Robert A.; Anderson, Kristin E.; Cerhan, James R; Anderson, V. Elving; Sellers, Thomas A.

In: Cancer Causes and Control, Vol. 13, No. 4, 2002, p. 333-341.

Research output: Contribution to journalArticle

Grabrick, Dawn M. ; Vierkant, Robert A. ; Anderson, Kristin E. ; Cerhan, James R ; Anderson, V. Elving ; Sellers, Thomas A. / Association of correlates of endogenous hormonal exposure with breast cancer risk in 426 families (United States). In: Cancer Causes and Control. 2002 ; Vol. 13, No. 4. pp. 333-341.
@article{ca392cb6332747109c184849e74f8c78,
title = "Association of correlates of endogenous hormonal exposure with breast cancer risk in 426 families (United States)",
abstract = "Objective: Women with a strong family history of breast cancer are at significantly increased risk of developing the disease. There is emerging evidence that certain reproductive factors may further elevate risk in these women. We examined whether a family history of breast cancer modifies the association between correlates of endogenous hormonal exposures and breast cancer in a study of 426 families ascertained through breast cancer probands. Methods: Analyses of reproductive factors and breast cancer were performed on 395 sisters and daughters of probands, 3014 nieces and granddaughters, and 2768 marry-ins. Results: Through 226,266 person-years of follow-up since 1952, 240 women developed breast cancer. No statistically significant interactions were observed between relationship to proband and age at menarche, age at menopause, other characteristics of the menstrual cycle, parity, age at first and last birth, infertility, and total ovulatory years. Conclusions: Our findings suggest that most reproductive factors influence breast cancer risk similarly in women with and without a family history of breast cancer. Further studies are needed on individuals who are more homogeneous with regard to hereditary background. However, other options for prevention, such as prophylactic surgery or chemoprevention, may be necessary to have a substantial impact on risk reduction in women at high genetic risk.",
keywords = "Breast neoplasms, Epidemiology, Pedigree, Reproductive history, Risk factors",
author = "Grabrick, {Dawn M.} and Vierkant, {Robert A.} and Anderson, {Kristin E.} and Cerhan, {James R} and Anderson, {V. Elving} and Sellers, {Thomas A.}",
year = "2002",
doi = "10.1023/A:1015292724384",
language = "English (US)",
volume = "13",
pages = "333--341",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "4",

}

TY - JOUR

T1 - Association of correlates of endogenous hormonal exposure with breast cancer risk in 426 families (United States)

AU - Grabrick, Dawn M.

AU - Vierkant, Robert A.

AU - Anderson, Kristin E.

AU - Cerhan, James R

AU - Anderson, V. Elving

AU - Sellers, Thomas A.

PY - 2002

Y1 - 2002

N2 - Objective: Women with a strong family history of breast cancer are at significantly increased risk of developing the disease. There is emerging evidence that certain reproductive factors may further elevate risk in these women. We examined whether a family history of breast cancer modifies the association between correlates of endogenous hormonal exposures and breast cancer in a study of 426 families ascertained through breast cancer probands. Methods: Analyses of reproductive factors and breast cancer were performed on 395 sisters and daughters of probands, 3014 nieces and granddaughters, and 2768 marry-ins. Results: Through 226,266 person-years of follow-up since 1952, 240 women developed breast cancer. No statistically significant interactions were observed between relationship to proband and age at menarche, age at menopause, other characteristics of the menstrual cycle, parity, age at first and last birth, infertility, and total ovulatory years. Conclusions: Our findings suggest that most reproductive factors influence breast cancer risk similarly in women with and without a family history of breast cancer. Further studies are needed on individuals who are more homogeneous with regard to hereditary background. However, other options for prevention, such as prophylactic surgery or chemoprevention, may be necessary to have a substantial impact on risk reduction in women at high genetic risk.

AB - Objective: Women with a strong family history of breast cancer are at significantly increased risk of developing the disease. There is emerging evidence that certain reproductive factors may further elevate risk in these women. We examined whether a family history of breast cancer modifies the association between correlates of endogenous hormonal exposures and breast cancer in a study of 426 families ascertained through breast cancer probands. Methods: Analyses of reproductive factors and breast cancer were performed on 395 sisters and daughters of probands, 3014 nieces and granddaughters, and 2768 marry-ins. Results: Through 226,266 person-years of follow-up since 1952, 240 women developed breast cancer. No statistically significant interactions were observed between relationship to proband and age at menarche, age at menopause, other characteristics of the menstrual cycle, parity, age at first and last birth, infertility, and total ovulatory years. Conclusions: Our findings suggest that most reproductive factors influence breast cancer risk similarly in women with and without a family history of breast cancer. Further studies are needed on individuals who are more homogeneous with regard to hereditary background. However, other options for prevention, such as prophylactic surgery or chemoprevention, may be necessary to have a substantial impact on risk reduction in women at high genetic risk.

KW - Breast neoplasms

KW - Epidemiology

KW - Pedigree

KW - Reproductive history

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=0036001458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036001458&partnerID=8YFLogxK

U2 - 10.1023/A:1015292724384

DO - 10.1023/A:1015292724384

M3 - Article

C2 - 12074503

AN - SCOPUS:0036001458

VL - 13

SP - 333

EP - 341

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 4

ER -