Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients

Liming Weng, Eoin Quinlivan, Yan Gong, Amber L. Beitelshees, Mohamed H. Shahin, Stephen T Turner, Arlene B. Chapman, John G. Gums, Julie A. Johnson, Reginald F. Frye, Timothy J. Garrett, Rhonda M. Cooper-DeHoff

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The three branched amino acids (valine, leucine, and isoleucine) and two aromatic amino acids (tyrosine and phenylalanine) have been associated with many adverse metabolic pathways, including diabetes. However, these associations have been identified primarily in otherwise healthy Caucasian populations. We aimed to investigate the association of this five-amino-acid signature with metabolic syndrome and impaired fasting glucose (IFG) in a hypertensive cohort of Caucasian and African Americans. Methods: We analyzed data from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies PEAR and PEAR2 conducted between 2005 and 2014. Subjects were enrolled at the University of Florida (Gainesville, FL), Emory University (Atlanta, GA), and Mayo Clinic (Rochester, MN). A total of 898 patients with essential hypertension were included in this study. Presence of metabolic syndrome and IFG at baseline were determined on the basis of measurements of demographic and biochemical data. Levels of the five amino acids were quantified by liquid chromatography-tandem mass spectroscopy (LC-MS/MS). Results: With a multiple logistic regression model, we found that all five amino acids were significantly associated with metabolic syndrome in both Caucasian and African Americans. IFG and the five amino acids were associated in the Caucasian Americans. Only valine was significantly associated with IFG in African Americans. Conclusion: In both Caucasian and African Americans with uncomplicated hypertension, plasma levels of the five-amino-acid signature are associated with metabolic syndrome. Additionally, in Caucasians we have confirmed the five-amino-acid signature was associated with IFG.

Original languageEnglish (US)
Pages (from-to)195-202
Number of pages8
JournalMetabolic Syndrome and Related Disorders
Volume13
Issue number5
DOIs
StatePublished - Jun 1 2015

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Aromatic Amino Acids
Fasting
Amino Acids
Glucose
African Americans
Valine
Antihypertensive Agents
Logistic Models
Isoleucine
Pharmacogenetics
Metabolic Networks and Pathways
Phenylalanine
Leucine
Liquid Chromatography
Tyrosine
Mass Spectrometry
Demography
Hypertension
Population

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients. / Weng, Liming; Quinlivan, Eoin; Gong, Yan; Beitelshees, Amber L.; Shahin, Mohamed H.; Turner, Stephen T; Chapman, Arlene B.; Gums, John G.; Johnson, Julie A.; Frye, Reginald F.; Garrett, Timothy J.; Cooper-DeHoff, Rhonda M.

In: Metabolic Syndrome and Related Disorders, Vol. 13, No. 5, 01.06.2015, p. 195-202.

Research output: Contribution to journalArticle

Weng, L, Quinlivan, E, Gong, Y, Beitelshees, AL, Shahin, MH, Turner, ST, Chapman, AB, Gums, JG, Johnson, JA, Frye, RF, Garrett, TJ & Cooper-DeHoff, RM 2015, 'Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients', Metabolic Syndrome and Related Disorders, vol. 13, no. 5, pp. 195-202. https://doi.org/10.1089/met.2014.0132
Weng, Liming ; Quinlivan, Eoin ; Gong, Yan ; Beitelshees, Amber L. ; Shahin, Mohamed H. ; Turner, Stephen T ; Chapman, Arlene B. ; Gums, John G. ; Johnson, Julie A. ; Frye, Reginald F. ; Garrett, Timothy J. ; Cooper-DeHoff, Rhonda M. / Association of branched and aromatic amino acids levels with metabolic syndrome and impaired fasting glucose in hypertensive patients. In: Metabolic Syndrome and Related Disorders. 2015 ; Vol. 13, No. 5. pp. 195-202.
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AU - Quinlivan, Eoin

AU - Gong, Yan

AU - Beitelshees, Amber L.

AU - Shahin, Mohamed H.

AU - Turner, Stephen T

AU - Chapman, Arlene B.

AU - Gums, John G.

AU - Johnson, Julie A.

AU - Frye, Reginald F.

AU - Garrett, Timothy J.

AU - Cooper-DeHoff, Rhonda M.

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N2 - Background: The three branched amino acids (valine, leucine, and isoleucine) and two aromatic amino acids (tyrosine and phenylalanine) have been associated with many adverse metabolic pathways, including diabetes. However, these associations have been identified primarily in otherwise healthy Caucasian populations. We aimed to investigate the association of this five-amino-acid signature with metabolic syndrome and impaired fasting glucose (IFG) in a hypertensive cohort of Caucasian and African Americans. Methods: We analyzed data from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies PEAR and PEAR2 conducted between 2005 and 2014. Subjects were enrolled at the University of Florida (Gainesville, FL), Emory University (Atlanta, GA), and Mayo Clinic (Rochester, MN). A total of 898 patients with essential hypertension were included in this study. Presence of metabolic syndrome and IFG at baseline were determined on the basis of measurements of demographic and biochemical data. Levels of the five amino acids were quantified by liquid chromatography-tandem mass spectroscopy (LC-MS/MS). Results: With a multiple logistic regression model, we found that all five amino acids were significantly associated with metabolic syndrome in both Caucasian and African Americans. IFG and the five amino acids were associated in the Caucasian Americans. Only valine was significantly associated with IFG in African Americans. Conclusion: In both Caucasian and African Americans with uncomplicated hypertension, plasma levels of the five-amino-acid signature are associated with metabolic syndrome. Additionally, in Caucasians we have confirmed the five-amino-acid signature was associated with IFG.

AB - Background: The three branched amino acids (valine, leucine, and isoleucine) and two aromatic amino acids (tyrosine and phenylalanine) have been associated with many adverse metabolic pathways, including diabetes. However, these associations have been identified primarily in otherwise healthy Caucasian populations. We aimed to investigate the association of this five-amino-acid signature with metabolic syndrome and impaired fasting glucose (IFG) in a hypertensive cohort of Caucasian and African Americans. Methods: We analyzed data from the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies PEAR and PEAR2 conducted between 2005 and 2014. Subjects were enrolled at the University of Florida (Gainesville, FL), Emory University (Atlanta, GA), and Mayo Clinic (Rochester, MN). A total of 898 patients with essential hypertension were included in this study. Presence of metabolic syndrome and IFG at baseline were determined on the basis of measurements of demographic and biochemical data. Levels of the five amino acids were quantified by liquid chromatography-tandem mass spectroscopy (LC-MS/MS). Results: With a multiple logistic regression model, we found that all five amino acids were significantly associated with metabolic syndrome in both Caucasian and African Americans. IFG and the five amino acids were associated in the Caucasian Americans. Only valine was significantly associated with IFG in African Americans. Conclusion: In both Caucasian and African Americans with uncomplicated hypertension, plasma levels of the five-amino-acid signature are associated with metabolic syndrome. Additionally, in Caucasians we have confirmed the five-amino-acid signature was associated with IFG.

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