Abstract
Background and Purpose- Evidence suggests that atrial fibrillation (AF) is associated with increased risk of cognitive decline and dementia, even in the absence of stroke. White matter disease (WMD) is a potential mechanism linking AF to cognitive impairment. In this study, we explored the association between prevalent AF and WMD. Methods- We performed a cross-sectional analysis of participants attending the ARIC-NCS (Atherosclerosis Risk in Communities-Neurocognitive Study) in 2011 to 2013 who underwent brain magnetic resonance imaging. AF was ascertained from study visit electrocardiograms or prior hospitalization codes. Extent of WMD was defined by measures of white matter (WM) microstructural integrity and WM hyperintensity volume. Multivariable linear regression models were used to assess the association between AF and WMD. Results- Among 1899 participants (mean age, 76 years; 28% black; 60% women), 133 (7%) had prevalent AF. After multivariable adjustment, differences between participants with and without AF were -0.001 (95% CI, -0.006 to 0.004) for global WM fractional anisotropy, 0.031×10-4 mm2/s (95% CI, -0.075 to 0.137) for global WM mean diffusivity, and 0.08 mm3 (95% CI, -0.14 to 0.30) for WM hyperintensity volume. Conclusions- The results suggest that there is no association between prevalent AF and WMD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 989-991 |
| Number of pages | 3 |
| Journal | Stroke |
| Volume | 50 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2019 |
| Externally published | Yes |
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Keywords
- atrial fibrillation
- cognitive dysfunction
- dementia
- leukoencephalopathies
- white matter
ASJC Scopus subject areas
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
- Advanced and Specialized Nursing
Cite this
Association of Atrial Fibrillation With White Matter Disease. / Shao, Iris Yuefan; Power, Melinda C.; Mosley, Thomas; Jack, Clifford R Jr.; Gottesman, Rebecca F.; Chen, Lin Y.; Norby, Faye L.; Soliman, Elsayed Z.; Alonso, Alvaro.
In: Stroke, Vol. 50, No. 4, 01.04.2019, p. 989-991.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of Atrial Fibrillation With White Matter Disease
AU - Shao, Iris Yuefan
AU - Power, Melinda C.
AU - Mosley, Thomas
AU - Jack, Clifford R Jr.
AU - Gottesman, Rebecca F.
AU - Chen, Lin Y.
AU - Norby, Faye L.
AU - Soliman, Elsayed Z.
AU - Alonso, Alvaro
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Background and Purpose- Evidence suggests that atrial fibrillation (AF) is associated with increased risk of cognitive decline and dementia, even in the absence of stroke. White matter disease (WMD) is a potential mechanism linking AF to cognitive impairment. In this study, we explored the association between prevalent AF and WMD. Methods- We performed a cross-sectional analysis of participants attending the ARIC-NCS (Atherosclerosis Risk in Communities-Neurocognitive Study) in 2011 to 2013 who underwent brain magnetic resonance imaging. AF was ascertained from study visit electrocardiograms or prior hospitalization codes. Extent of WMD was defined by measures of white matter (WM) microstructural integrity and WM hyperintensity volume. Multivariable linear regression models were used to assess the association between AF and WMD. Results- Among 1899 participants (mean age, 76 years; 28% black; 60% women), 133 (7%) had prevalent AF. After multivariable adjustment, differences between participants with and without AF were -0.001 (95% CI, -0.006 to 0.004) for global WM fractional anisotropy, 0.031×10-4 mm2/s (95% CI, -0.075 to 0.137) for global WM mean diffusivity, and 0.08 mm3 (95% CI, -0.14 to 0.30) for WM hyperintensity volume. Conclusions- The results suggest that there is no association between prevalent AF and WMD.
AB - Background and Purpose- Evidence suggests that atrial fibrillation (AF) is associated with increased risk of cognitive decline and dementia, even in the absence of stroke. White matter disease (WMD) is a potential mechanism linking AF to cognitive impairment. In this study, we explored the association between prevalent AF and WMD. Methods- We performed a cross-sectional analysis of participants attending the ARIC-NCS (Atherosclerosis Risk in Communities-Neurocognitive Study) in 2011 to 2013 who underwent brain magnetic resonance imaging. AF was ascertained from study visit electrocardiograms or prior hospitalization codes. Extent of WMD was defined by measures of white matter (WM) microstructural integrity and WM hyperintensity volume. Multivariable linear regression models were used to assess the association between AF and WMD. Results- Among 1899 participants (mean age, 76 years; 28% black; 60% women), 133 (7%) had prevalent AF. After multivariable adjustment, differences between participants with and without AF were -0.001 (95% CI, -0.006 to 0.004) for global WM fractional anisotropy, 0.031×10-4 mm2/s (95% CI, -0.075 to 0.137) for global WM mean diffusivity, and 0.08 mm3 (95% CI, -0.14 to 0.30) for WM hyperintensity volume. Conclusions- The results suggest that there is no association between prevalent AF and WMD.
KW - atrial fibrillation
KW - cognitive dysfunction
KW - dementia
KW - leukoencephalopathies
KW - white matter
UR - http://www.scopus.com/inward/record.url?scp=85063714058&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063714058&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.118.023386
DO - 10.1161/STROKEAHA.118.023386
M3 - Article
C2 - 30879437
AN - SCOPUS:85063714058
VL - 50
SP - 989
EP - 991
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 4
ER -