Association of atrial fibrillation and aortic atherosclerosis: A population-based study

Yoram Agmon, Buoy K. Khandheria, Irene Meissner, Gary Lee Schwartz, Tanya M. Petterson, W. Michael O'Fallon, Federico Gentile, Peter C. Spittell, Jack P. Whisnant, David O. Wiebers, Jody L. Covalt, James B. Sew

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective: To examine the association between atrial fibrillation (AF) and aortic atherosclerosis in the general population. Subjects and Methods: Transesophageal echocardiography was performed in 581 subjects, a random sample of the adult Olmsted County, Minnesota, population (45 years of age or older) participating in the Stroke Prevention: Assessment of Risk in a Community (SPARC) study. The frequency of aortic atherosclerosis was determined in 42 subjects with AF and compared with that in 539 subjects without AF (non-AF group). Results: Subjects with AF were significantly older than non-AF subjects (mean ± SD age, 82±10 vs 66±13 years, respectively: P<.001) and more commonly had hypertension (28 [66.7%] vs 288 [53.4%], respectively; P=.10). The 2 groups were similar in sex and frequency of diabetes mellitus, hyperlipidemia, or smoking history (P>.10). The odds of aortic atherosclerosis (of any degree) were 2.87 times greater (95% confidence interval [CI], 1.41-5.83; P=.004) and the odds of complex atherosclerosis (protruding atheroma <4 mm thick, mobile debris, or plaque ulceration) were 2.71 times greater (CI, 1.13-6.53; P=.03) in the AF group than in the non-AF group. Age was a significant predictor of aortic atherosclerosis (P<.001). After adjusting for age, the odds of atherosclerosis and complex atherosclerosis were not significantly different between the 2 groups (P=.13 and P=.75, respectively). Conclusions: In the general population, AF is associated with aortic atherosclerosis, including complex atherosclerosis. This association is related to age since both AF and aortic atherosclerosis are more frequent in the elderly population.

Original languageEnglish (US)
Pages (from-to)252-259
Number of pages8
JournalMayo Clinic Proceedings
Volume76
Issue number3
StatePublished - 2001

Fingerprint

Atrial Fibrillation
Atherosclerosis
Population
Confidence Intervals
Transesophageal Echocardiography
Atherosclerotic Plaques
Stroke

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Agmon, Y., Khandheria, B. K., Meissner, I., Schwartz, G. L., Petterson, T. M., Michael O'Fallon, W., ... Sew, J. B. (2001). Association of atrial fibrillation and aortic atherosclerosis: A population-based study. Mayo Clinic Proceedings, 76(3), 252-259.

Association of atrial fibrillation and aortic atherosclerosis : A population-based study. / Agmon, Yoram; Khandheria, Buoy K.; Meissner, Irene; Schwartz, Gary Lee; Petterson, Tanya M.; Michael O'Fallon, W.; Gentile, Federico; Spittell, Peter C.; Whisnant, Jack P.; Wiebers, David O.; Covalt, Jody L.; Sew, James B.

In: Mayo Clinic Proceedings, Vol. 76, No. 3, 2001, p. 252-259.

Research output: Contribution to journalArticle

Agmon, Y, Khandheria, BK, Meissner, I, Schwartz, GL, Petterson, TM, Michael O'Fallon, W, Gentile, F, Spittell, PC, Whisnant, JP, Wiebers, DO, Covalt, JL & Sew, JB 2001, 'Association of atrial fibrillation and aortic atherosclerosis: A population-based study', Mayo Clinic Proceedings, vol. 76, no. 3, pp. 252-259.
Agmon, Yoram ; Khandheria, Buoy K. ; Meissner, Irene ; Schwartz, Gary Lee ; Petterson, Tanya M. ; Michael O'Fallon, W. ; Gentile, Federico ; Spittell, Peter C. ; Whisnant, Jack P. ; Wiebers, David O. ; Covalt, Jody L. ; Sew, James B. / Association of atrial fibrillation and aortic atherosclerosis : A population-based study. In: Mayo Clinic Proceedings. 2001 ; Vol. 76, No. 3. pp. 252-259.
@article{2e6284c9dbab4922841739c8fb1f37c7,
title = "Association of atrial fibrillation and aortic atherosclerosis: A population-based study",
abstract = "Objective: To examine the association between atrial fibrillation (AF) and aortic atherosclerosis in the general population. Subjects and Methods: Transesophageal echocardiography was performed in 581 subjects, a random sample of the adult Olmsted County, Minnesota, population (45 years of age or older) participating in the Stroke Prevention: Assessment of Risk in a Community (SPARC) study. The frequency of aortic atherosclerosis was determined in 42 subjects with AF and compared with that in 539 subjects without AF (non-AF group). Results: Subjects with AF were significantly older than non-AF subjects (mean ± SD age, 82±10 vs 66±13 years, respectively: P<.001) and more commonly had hypertension (28 [66.7{\%}] vs 288 [53.4{\%}], respectively; P=.10). The 2 groups were similar in sex and frequency of diabetes mellitus, hyperlipidemia, or smoking history (P>.10). The odds of aortic atherosclerosis (of any degree) were 2.87 times greater (95{\%} confidence interval [CI], 1.41-5.83; P=.004) and the odds of complex atherosclerosis (protruding atheroma <4 mm thick, mobile debris, or plaque ulceration) were 2.71 times greater (CI, 1.13-6.53; P=.03) in the AF group than in the non-AF group. Age was a significant predictor of aortic atherosclerosis (P<.001). After adjusting for age, the odds of atherosclerosis and complex atherosclerosis were not significantly different between the 2 groups (P=.13 and P=.75, respectively). Conclusions: In the general population, AF is associated with aortic atherosclerosis, including complex atherosclerosis. This association is related to age since both AF and aortic atherosclerosis are more frequent in the elderly population.",
author = "Yoram Agmon and Khandheria, {Buoy K.} and Irene Meissner and Schwartz, {Gary Lee} and Petterson, {Tanya M.} and {Michael O'Fallon}, W. and Federico Gentile and Spittell, {Peter C.} and Whisnant, {Jack P.} and Wiebers, {David O.} and Covalt, {Jody L.} and Sew, {James B.}",
year = "2001",
language = "English (US)",
volume = "76",
pages = "252--259",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "3",

}

TY - JOUR

T1 - Association of atrial fibrillation and aortic atherosclerosis

T2 - A population-based study

AU - Agmon, Yoram

AU - Khandheria, Buoy K.

AU - Meissner, Irene

AU - Schwartz, Gary Lee

AU - Petterson, Tanya M.

AU - Michael O'Fallon, W.

AU - Gentile, Federico

AU - Spittell, Peter C.

AU - Whisnant, Jack P.

AU - Wiebers, David O.

AU - Covalt, Jody L.

AU - Sew, James B.

PY - 2001

Y1 - 2001

N2 - Objective: To examine the association between atrial fibrillation (AF) and aortic atherosclerosis in the general population. Subjects and Methods: Transesophageal echocardiography was performed in 581 subjects, a random sample of the adult Olmsted County, Minnesota, population (45 years of age or older) participating in the Stroke Prevention: Assessment of Risk in a Community (SPARC) study. The frequency of aortic atherosclerosis was determined in 42 subjects with AF and compared with that in 539 subjects without AF (non-AF group). Results: Subjects with AF were significantly older than non-AF subjects (mean ± SD age, 82±10 vs 66±13 years, respectively: P<.001) and more commonly had hypertension (28 [66.7%] vs 288 [53.4%], respectively; P=.10). The 2 groups were similar in sex and frequency of diabetes mellitus, hyperlipidemia, or smoking history (P>.10). The odds of aortic atherosclerosis (of any degree) were 2.87 times greater (95% confidence interval [CI], 1.41-5.83; P=.004) and the odds of complex atherosclerosis (protruding atheroma <4 mm thick, mobile debris, or plaque ulceration) were 2.71 times greater (CI, 1.13-6.53; P=.03) in the AF group than in the non-AF group. Age was a significant predictor of aortic atherosclerosis (P<.001). After adjusting for age, the odds of atherosclerosis and complex atherosclerosis were not significantly different between the 2 groups (P=.13 and P=.75, respectively). Conclusions: In the general population, AF is associated with aortic atherosclerosis, including complex atherosclerosis. This association is related to age since both AF and aortic atherosclerosis are more frequent in the elderly population.

AB - Objective: To examine the association between atrial fibrillation (AF) and aortic atherosclerosis in the general population. Subjects and Methods: Transesophageal echocardiography was performed in 581 subjects, a random sample of the adult Olmsted County, Minnesota, population (45 years of age or older) participating in the Stroke Prevention: Assessment of Risk in a Community (SPARC) study. The frequency of aortic atherosclerosis was determined in 42 subjects with AF and compared with that in 539 subjects without AF (non-AF group). Results: Subjects with AF were significantly older than non-AF subjects (mean ± SD age, 82±10 vs 66±13 years, respectively: P<.001) and more commonly had hypertension (28 [66.7%] vs 288 [53.4%], respectively; P=.10). The 2 groups were similar in sex and frequency of diabetes mellitus, hyperlipidemia, or smoking history (P>.10). The odds of aortic atherosclerosis (of any degree) were 2.87 times greater (95% confidence interval [CI], 1.41-5.83; P=.004) and the odds of complex atherosclerosis (protruding atheroma <4 mm thick, mobile debris, or plaque ulceration) were 2.71 times greater (CI, 1.13-6.53; P=.03) in the AF group than in the non-AF group. Age was a significant predictor of aortic atherosclerosis (P<.001). After adjusting for age, the odds of atherosclerosis and complex atherosclerosis were not significantly different between the 2 groups (P=.13 and P=.75, respectively). Conclusions: In the general population, AF is associated with aortic atherosclerosis, including complex atherosclerosis. This association is related to age since both AF and aortic atherosclerosis are more frequent in the elderly population.

UR - http://www.scopus.com/inward/record.url?scp=0035096675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035096675&partnerID=8YFLogxK

M3 - Article

C2 - 11243271

AN - SCOPUS:0035096675

VL - 76

SP - 252

EP - 259

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 3

ER -