Association of APOE polymorphisms with disease severity in MS is limited to women

O. H. Kantarci, D. D. Hebrink, S. J. Achenbach, S. J. Pittock, A. Altintas, J. L. Schaefer-Klein, E. J. Atkinson, M. De Andrade, C. T. McMurray, M. Rodriguez, Brian G. Weinshenker

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The authors studied the association of an exon 4 (E4*ε2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*ε2 allele took longer to attain an Expanded Disability Status Scale score of 6 (p = 0.015) and had more favorable ranked severity scores than noncarriers (p = 0.009). There was no association in men. Alleles ε3 or ε4 and promoter polymorphisms were not associated with disease course or severity.

Original languageEnglish (US)
Pages (from-to)811-814
Number of pages4
JournalNeurology
Volume62
Issue number5
DOIs
StatePublished - Mar 9 2004

ASJC Scopus subject areas

  • Clinical Neurology

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