Association of APOE polymorphisms with disease severity in MS is limited to women

O. H. Kantarci; D. D. Hebrink; S. J. Achenbach; S. J. Pittock; A. Altintas; J. L. Schaefer-Klein; E. J. Atkinson; M. De Andrade; C. T. McMurray; M. Rodriguez; Brian G. Weinshenker

doi:10.1212/01.WNL.0000113721.83287.83

Association of APOE polymorphisms with disease severity in MS is limited to women

O. H. Kantarci, D. D. Hebrink, S. J. Achenbach, S. J. Pittock, A. Altintas, J. L. Schaefer-Klein, E. J. Atkinson, M. De Andrade, C. T. McMurray, M. Rodriguez, Brian G. Weinshenker

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70 Scopus citations

Abstract

The authors studied the association of an exon 4 (E4*ε2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*ε2 allele took longer to attain an Expanded Disability Status Scale score of 6 (p = 0.015) and had more favorable ranked severity scores than noncarriers (p = 0.009). There was no association in men. Alleles ε3 or ε4 and promoter polymorphisms were not associated with disease course or severity.

Original language	English (US)
Pages (from-to)	811-814
Number of pages	4
Journal	Neurology
Volume	62
Issue number	5
DOIs	https://doi.org/10.1212/01.WNL.0000113721.83287.83
State	Published - Mar 9 2004

ASJC Scopus subject areas

Clinical Neurology

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title = "Association of APOE polymorphisms with disease severity in MS is limited to women",

abstract = "The authors studied the association of an exon 4 (E4*ε2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*ε2 allele took longer to attain an Expanded Disability Status Scale score of 6 (p = 0.015) and had more favorable ranked severity scores than noncarriers (p = 0.009). There was no association in men. Alleles ε3 or ε4 and promoter polymorphisms were not associated with disease course or severity.",

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T1 - Association of APOE polymorphisms with disease severity in MS is limited to women

AU - Kantarci, O. H.

AU - Hebrink, D. D.

AU - Achenbach, S. J.

AU - Pittock, S. J.

AU - Altintas, A.

AU - Schaefer-Klein, J. L.

AU - Atkinson, E. J.

AU - De Andrade, M.

AU - McMurray, C. T.

AU - Rodriguez, M.

AU - Weinshenker, Brian G.

PY - 2004/3/9

Y1 - 2004/3/9

N2 - The authors studied the association of an exon 4 (E4*ε2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*ε2 allele took longer to attain an Expanded Disability Status Scale score of 6 (p = 0.015) and had more favorable ranked severity scores than noncarriers (p = 0.009). There was no association in men. Alleles ε3 or ε4 and promoter polymorphisms were not associated with disease course or severity.

AB - The authors studied the association of an exon 4 (E4*ε2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*ε2 allele took longer to attain an Expanded Disability Status Scale score of 6 (p = 0.015) and had more favorable ranked severity scores than noncarriers (p = 0.009). There was no association in men. Alleles ε3 or ε4 and promoter polymorphisms were not associated with disease course or severity.

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Association of APOE polymorphisms with disease severity in MS is limited to women

Abstract

ASJC Scopus subject areas

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