TY - JOUR
T1 - Association of ambulatory blood pressure with ischemic brain injury
AU - Schwartz, Gary L.
AU - Bailey, Kent R.
AU - Mosley, Thomas
AU - Knopman, David S.
AU - Jack, Clifford R.
AU - Canzanello, Vincent J.
AU - Turner, Stephen T.
PY - 2007/6
Y1 - 2007/6
N2 - Cerebral white matter hyperintensities on brain MRI (leukoaraiosis) are associated with increased risk of stroke and dementia. To assess the relationships of blood pressure level and circadian pattern with leukoaraiosis, we obtained 24-hour ambulatory blood pressure recordings and brain magnetic resonance images in 343 white and 267 black adults who were members of sibships that had ≥2 siblings with essential hypertension. In multiple linear regression models, factors associated with greater leukoaraiosis in both racial groups included age (P≤0.002), homocysteine levels (P≤0.006), and brain volume (P≤0.008). In blacks, ambulatory blood pressure measures associated with greater leukoaraiosis were higher awake, asleep, and 24-hour systolic and diastolic levels (P≤0.009 for each). In addition, there was a trend for smaller nocturnal declines in systolic and diastolic levels (ie, nondipping patterns) to be associated with greater leukoaraiosis, and all of these associations, except nondipping of diastolic level, remained or became significant after controlling for office blood pressure (P<0.05 for each). In whites, among ambulatory blood pressure measures, only higher asleep diastolic levels trended toward association with greater leukoaraiosis. However, similar to findings in blacks, nondipping of systolic and diastolic ambulatory blood pressure levels were each associated with greater leukoaraiosis (P≤0.008), and all of these associations remained or became significant after controlling for office blood pressure (P≤0.009 for each). Higher ambulatory blood pressure levels and a nondipping circadian pattern contribute to greater leukoaraiosis volume after controlling for office blood pressure.
AB - Cerebral white matter hyperintensities on brain MRI (leukoaraiosis) are associated with increased risk of stroke and dementia. To assess the relationships of blood pressure level and circadian pattern with leukoaraiosis, we obtained 24-hour ambulatory blood pressure recordings and brain magnetic resonance images in 343 white and 267 black adults who were members of sibships that had ≥2 siblings with essential hypertension. In multiple linear regression models, factors associated with greater leukoaraiosis in both racial groups included age (P≤0.002), homocysteine levels (P≤0.006), and brain volume (P≤0.008). In blacks, ambulatory blood pressure measures associated with greater leukoaraiosis were higher awake, asleep, and 24-hour systolic and diastolic levels (P≤0.009 for each). In addition, there was a trend for smaller nocturnal declines in systolic and diastolic levels (ie, nondipping patterns) to be associated with greater leukoaraiosis, and all of these associations, except nondipping of diastolic level, remained or became significant after controlling for office blood pressure (P<0.05 for each). In whites, among ambulatory blood pressure measures, only higher asleep diastolic levels trended toward association with greater leukoaraiosis. However, similar to findings in blacks, nondipping of systolic and diastolic ambulatory blood pressure levels were each associated with greater leukoaraiosis (P≤0.008), and all of these associations remained or became significant after controlling for office blood pressure (P≤0.009 for each). Higher ambulatory blood pressure levels and a nondipping circadian pattern contribute to greater leukoaraiosis volume after controlling for office blood pressure.
KW - Ambulatory blood pressure
KW - Hypertension
KW - Leukoaraiosis
KW - Predictors
KW - Target organ injury
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U2 - 10.1161/HYPERTENSIONAHA.106.078691
DO - 10.1161/HYPERTENSIONAHA.106.078691
M3 - Article
C2 - 17404188
AN - SCOPUS:34249291293
SN - 0194-911X
VL - 49
SP - 1228
EP - 1234
JO - Hypertension
JF - Hypertension
IS - 6
ER -