Association of adiposity, telomere length and mortality: Data from the NHANES 1999-2002

J. A. Batsis, T. A. Mackenzie, E. Vasquez, C. M. Germain, R. T. Emeny, P. Rippberger, Francisco Lopez-Jimenez, S. J. Bartels

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Background/Objectives:Telomere shortening is associated with age and risk of medical comorbidity. We assessed the relationship between measures of adiposity, leukocyte telomere length, and mortality and whether it is modified by age.Subjects/Methods:Subjects with dual-energy X-ray absorptiometry measures were identified using the National Health and Nutrition Examination Survey 1999-2002. Obesity was categorized using two body fat definitions (BF1%: men 3/425%; females 3/435%; BF2% 3/428% and 3/438%, respectively), body mass index (BMI) and waist circumference (WC; men 3/4102 cm; females 3/488 cm). Telomere length relative to standard reference DNA (T/S ratio) was assessed using quantitative PCR. Weighted multivariable regression models evaluated the association of telomere length with adiposity, both continuously and categorically (low/normal BF%, low/high WC and standard BMI categories). Differences in telomere length by age and adiposity were ascertained and subsequent models were stratified by age. Proportional hazard models assessed the risk of mortality by adiposity status. A telomere by adiposity interaction was tested in the entire cohort and by age category (<60 vs 3/460 years; <70 vs 3/470 years).Results:We identified 7827 subjects. Mean age was 46.1 years. Overall telomere length was 1.05±0.01 (s.e.) that differed by BF1% (low/high: 1.12±0.02 vs 1.03±0.02; P<0.001), BF2% (1.02±0.02 vs 1.11±0.02; P<0.001), BMI (underweight 1.08±0.03; normal 1.09±0.02; overweight 1.04±0.02; and obese 1.03±0.02;P<0.001) and WC (low/high 1.09±0.02 vs 1.02±0.02; P<0.001). Adjusted β-coefficients evaluating the relationship between telomere length and adiposity (measured continuously) were as follows: BF1% (β='0.0033±0.0008; P<0.001), BF2% ('0.041±0.008; P<0.001), BMI (β='0.025±0.0008; P=0.005) and WC (β='0.0011±0.0004; P=0.007). High BF% (BF1%: β='0.035±0.011; P=0.002; BF2%: β='0.041±0.008; P<0.001) and WC (β='0.035±0.011; P=0.008) were inversely related to telomere length (TL). Stratifying by age, high BF1% ('0.061±0.013), BF2% ('0.065±0.01), BMI-obesity ('0.07±0.015) and high WC ('0.048±0.013) were significant (all P<0.001). This association diminished with increasing age. In older participants, TL was inversely related to mortality (hazard ratio 0.36 (0.27, 0.49)), as were those classified by BF1% (0.68 (0.56, 0.81)), BF2% (0.75 (0.65, 0.80)), BMI (0.50 (0.42, 0.60)) and WC (0.72 (0.63, 0.83)). No interaction was observed between adiposity status, telomere length and mortality.Conclusions:Obesity is associated with shorter telomere length in young participants, a relationship that diminishes with increasing age. It does not moderate the relationship with mortality.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalInternational Journal of Obesity
Volume42
Issue number2
DOIs
StatePublished - Feb 1 2018

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Nutrition Surveys
Telomere
Adiposity
Mortality
Body Mass Index
Obesity
Telomere Shortening
Thinness
Photon Absorptiometry
Waist Circumference
Proportional Hazards Models
Adipose Tissue
Comorbidity
Leukocytes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Batsis, J. A., Mackenzie, T. A., Vasquez, E., Germain, C. M., Emeny, R. T., Rippberger, P., ... Bartels, S. J. (2018). Association of adiposity, telomere length and mortality: Data from the NHANES 1999-2002. International Journal of Obesity, 42(2), 198-204. https://doi.org/10.1038/ijo.2017.202

Association of adiposity, telomere length and mortality : Data from the NHANES 1999-2002. / Batsis, J. A.; Mackenzie, T. A.; Vasquez, E.; Germain, C. M.; Emeny, R. T.; Rippberger, P.; Lopez-Jimenez, Francisco; Bartels, S. J.

In: International Journal of Obesity, Vol. 42, No. 2, 01.02.2018, p. 198-204.

Research output: Contribution to journalReview article

Batsis, JA, Mackenzie, TA, Vasquez, E, Germain, CM, Emeny, RT, Rippberger, P, Lopez-Jimenez, F & Bartels, SJ 2018, 'Association of adiposity, telomere length and mortality: Data from the NHANES 1999-2002', International Journal of Obesity, vol. 42, no. 2, pp. 198-204. https://doi.org/10.1038/ijo.2017.202
Batsis JA, Mackenzie TA, Vasquez E, Germain CM, Emeny RT, Rippberger P et al. Association of adiposity, telomere length and mortality: Data from the NHANES 1999-2002. International Journal of Obesity. 2018 Feb 1;42(2):198-204. https://doi.org/10.1038/ijo.2017.202
Batsis, J. A. ; Mackenzie, T. A. ; Vasquez, E. ; Germain, C. M. ; Emeny, R. T. ; Rippberger, P. ; Lopez-Jimenez, Francisco ; Bartels, S. J. / Association of adiposity, telomere length and mortality : Data from the NHANES 1999-2002. In: International Journal of Obesity. 2018 ; Vol. 42, No. 2. pp. 198-204.
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title = "Association of adiposity, telomere length and mortality: Data from the NHANES 1999-2002",
abstract = "Background/Objectives:Telomere shortening is associated with age and risk of medical comorbidity. We assessed the relationship between measures of adiposity, leukocyte telomere length, and mortality and whether it is modified by age.Subjects/Methods:Subjects with dual-energy X-ray absorptiometry measures were identified using the National Health and Nutrition Examination Survey 1999-2002. Obesity was categorized using two body fat definitions (BF1{\%}: men 3/425{\%}; females 3/435{\%}; BF2{\%} 3/428{\%} and 3/438{\%}, respectively), body mass index (BMI) and waist circumference (WC; men 3/4102 cm; females 3/488 cm). Telomere length relative to standard reference DNA (T/S ratio) was assessed using quantitative PCR. Weighted multivariable regression models evaluated the association of telomere length with adiposity, both continuously and categorically (low/normal BF{\%}, low/high WC and standard BMI categories). Differences in telomere length by age and adiposity were ascertained and subsequent models were stratified by age. Proportional hazard models assessed the risk of mortality by adiposity status. A telomere by adiposity interaction was tested in the entire cohort and by age category (<60 vs 3/460 years; <70 vs 3/470 years).Results:We identified 7827 subjects. Mean age was 46.1 years. Overall telomere length was 1.05±0.01 (s.e.) that differed by BF1{\%} (low/high: 1.12±0.02 vs 1.03±0.02; P<0.001), BF2{\%} (1.02±0.02 vs 1.11±0.02; P<0.001), BMI (underweight 1.08±0.03; normal 1.09±0.02; overweight 1.04±0.02; and obese 1.03±0.02;P<0.001) and WC (low/high 1.09±0.02 vs 1.02±0.02; P<0.001). Adjusted β-coefficients evaluating the relationship between telomere length and adiposity (measured continuously) were as follows: BF1{\%} (β='0.0033±0.0008; P<0.001), BF2{\%} ('0.041±0.008; P<0.001), BMI (β='0.025±0.0008; P=0.005) and WC (β='0.0011±0.0004; P=0.007). High BF{\%} (BF1{\%}: β='0.035±0.011; P=0.002; BF2{\%}: β='0.041±0.008; P<0.001) and WC (β='0.035±0.011; P=0.008) were inversely related to telomere length (TL). Stratifying by age, high BF1{\%} ('0.061±0.013), BF2{\%} ('0.065±0.01), BMI-obesity ('0.07±0.015) and high WC ('0.048±0.013) were significant (all P<0.001). This association diminished with increasing age. In older participants, TL was inversely related to mortality (hazard ratio 0.36 (0.27, 0.49)), as were those classified by BF1{\%} (0.68 (0.56, 0.81)), BF2{\%} (0.75 (0.65, 0.80)), BMI (0.50 (0.42, 0.60)) and WC (0.72 (0.63, 0.83)). No interaction was observed between adiposity status, telomere length and mortality.Conclusions:Obesity is associated with shorter telomere length in young participants, a relationship that diminishes with increasing age. It does not moderate the relationship with mortality.",
author = "Batsis, {J. A.} and Mackenzie, {T. A.} and E. Vasquez and Germain, {C. M.} and Emeny, {R. T.} and P. Rippberger and Francisco Lopez-Jimenez and Bartels, {S. J.}",
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TY - JOUR

T1 - Association of adiposity, telomere length and mortality

T2 - Data from the NHANES 1999-2002

AU - Batsis, J. A.

AU - Mackenzie, T. A.

AU - Vasquez, E.

AU - Germain, C. M.

AU - Emeny, R. T.

AU - Rippberger, P.

AU - Lopez-Jimenez, Francisco

AU - Bartels, S. J.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background/Objectives:Telomere shortening is associated with age and risk of medical comorbidity. We assessed the relationship between measures of adiposity, leukocyte telomere length, and mortality and whether it is modified by age.Subjects/Methods:Subjects with dual-energy X-ray absorptiometry measures were identified using the National Health and Nutrition Examination Survey 1999-2002. Obesity was categorized using two body fat definitions (BF1%: men 3/425%; females 3/435%; BF2% 3/428% and 3/438%, respectively), body mass index (BMI) and waist circumference (WC; men 3/4102 cm; females 3/488 cm). Telomere length relative to standard reference DNA (T/S ratio) was assessed using quantitative PCR. Weighted multivariable regression models evaluated the association of telomere length with adiposity, both continuously and categorically (low/normal BF%, low/high WC and standard BMI categories). Differences in telomere length by age and adiposity were ascertained and subsequent models were stratified by age. Proportional hazard models assessed the risk of mortality by adiposity status. A telomere by adiposity interaction was tested in the entire cohort and by age category (<60 vs 3/460 years; <70 vs 3/470 years).Results:We identified 7827 subjects. Mean age was 46.1 years. Overall telomere length was 1.05±0.01 (s.e.) that differed by BF1% (low/high: 1.12±0.02 vs 1.03±0.02; P<0.001), BF2% (1.02±0.02 vs 1.11±0.02; P<0.001), BMI (underweight 1.08±0.03; normal 1.09±0.02; overweight 1.04±0.02; and obese 1.03±0.02;P<0.001) and WC (low/high 1.09±0.02 vs 1.02±0.02; P<0.001). Adjusted β-coefficients evaluating the relationship between telomere length and adiposity (measured continuously) were as follows: BF1% (β='0.0033±0.0008; P<0.001), BF2% ('0.041±0.008; P<0.001), BMI (β='0.025±0.0008; P=0.005) and WC (β='0.0011±0.0004; P=0.007). High BF% (BF1%: β='0.035±0.011; P=0.002; BF2%: β='0.041±0.008; P<0.001) and WC (β='0.035±0.011; P=0.008) were inversely related to telomere length (TL). Stratifying by age, high BF1% ('0.061±0.013), BF2% ('0.065±0.01), BMI-obesity ('0.07±0.015) and high WC ('0.048±0.013) were significant (all P<0.001). This association diminished with increasing age. In older participants, TL was inversely related to mortality (hazard ratio 0.36 (0.27, 0.49)), as were those classified by BF1% (0.68 (0.56, 0.81)), BF2% (0.75 (0.65, 0.80)), BMI (0.50 (0.42, 0.60)) and WC (0.72 (0.63, 0.83)). No interaction was observed between adiposity status, telomere length and mortality.Conclusions:Obesity is associated with shorter telomere length in young participants, a relationship that diminishes with increasing age. It does not moderate the relationship with mortality.

AB - Background/Objectives:Telomere shortening is associated with age and risk of medical comorbidity. We assessed the relationship between measures of adiposity, leukocyte telomere length, and mortality and whether it is modified by age.Subjects/Methods:Subjects with dual-energy X-ray absorptiometry measures were identified using the National Health and Nutrition Examination Survey 1999-2002. Obesity was categorized using two body fat definitions (BF1%: men 3/425%; females 3/435%; BF2% 3/428% and 3/438%, respectively), body mass index (BMI) and waist circumference (WC; men 3/4102 cm; females 3/488 cm). Telomere length relative to standard reference DNA (T/S ratio) was assessed using quantitative PCR. Weighted multivariable regression models evaluated the association of telomere length with adiposity, both continuously and categorically (low/normal BF%, low/high WC and standard BMI categories). Differences in telomere length by age and adiposity were ascertained and subsequent models were stratified by age. Proportional hazard models assessed the risk of mortality by adiposity status. A telomere by adiposity interaction was tested in the entire cohort and by age category (<60 vs 3/460 years; <70 vs 3/470 years).Results:We identified 7827 subjects. Mean age was 46.1 years. Overall telomere length was 1.05±0.01 (s.e.) that differed by BF1% (low/high: 1.12±0.02 vs 1.03±0.02; P<0.001), BF2% (1.02±0.02 vs 1.11±0.02; P<0.001), BMI (underweight 1.08±0.03; normal 1.09±0.02; overweight 1.04±0.02; and obese 1.03±0.02;P<0.001) and WC (low/high 1.09±0.02 vs 1.02±0.02; P<0.001). Adjusted β-coefficients evaluating the relationship between telomere length and adiposity (measured continuously) were as follows: BF1% (β='0.0033±0.0008; P<0.001), BF2% ('0.041±0.008; P<0.001), BMI (β='0.025±0.0008; P=0.005) and WC (β='0.0011±0.0004; P=0.007). High BF% (BF1%: β='0.035±0.011; P=0.002; BF2%: β='0.041±0.008; P<0.001) and WC (β='0.035±0.011; P=0.008) were inversely related to telomere length (TL). Stratifying by age, high BF1% ('0.061±0.013), BF2% ('0.065±0.01), BMI-obesity ('0.07±0.015) and high WC ('0.048±0.013) were significant (all P<0.001). This association diminished with increasing age. In older participants, TL was inversely related to mortality (hazard ratio 0.36 (0.27, 0.49)), as were those classified by BF1% (0.68 (0.56, 0.81)), BF2% (0.75 (0.65, 0.80)), BMI (0.50 (0.42, 0.60)) and WC (0.72 (0.63, 0.83)). No interaction was observed between adiposity status, telomere length and mortality.Conclusions:Obesity is associated with shorter telomere length in young participants, a relationship that diminishes with increasing age. It does not moderate the relationship with mortality.

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