Association of a myeloperoxidase promoter polymorphism with multiple sclerosis

Orhun H. Kantarci, Elizabeth J. Atkinson, David D. Hebrink, Cynthia T. McMurray, Brian G. Weinshenker

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Myeloperoxidase (MPO) generates hypochlorous acid and other reactive oxygen intermediates leading to tissue damage. MPO is expressed in macrophages-microglia in multiple sclerosis (MS) lesions. A G→A substitution that abolishes an SP1 transcription factor consensus sequence in the promoter reduces gene expression. We studied the association of the genetic variant with MS. We did not find an association with gender, age at onset, susceptibility to, or the course and severity of MS in a population-based sample of 122 patients from Olmsted County. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalJournal of neuroimmunology
Volume105
Issue number2
DOIs
StatePublished - Jun 26 2000

Keywords

  • Genetics
  • Multiple sclerosis
  • Myeloperoxidase
  • Prognosis
  • Susceptibility

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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