Association of a myeloperoxidase promoter polymorphism with multiple sclerosis

Orhun H. Kantarci; Elizabeth J. Atkinson; David D. Hebrink; Cynthia T. McMurray; Brian G. Weinshenker

doi:10.1016/S0165-5728(00)00198-3

Association of a myeloperoxidase promoter polymorphism with multiple sclerosis

Orhun H. Kantarci, Elizabeth J. Atkinson, David D. Hebrink, Cynthia T. McMurray, Brian G. Weinshenker

Neurology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Myeloperoxidase (MPO) generates hypochlorous acid and other reactive oxygen intermediates leading to tissue damage. MPO is expressed in macrophages-microglia in multiple sclerosis (MS) lesions. A G→A substitution that abolishes an SP1 transcription factor consensus sequence in the promoter reduces gene expression. We studied the association of the genetic variant with MS. We did not find an association with gender, age at onset, susceptibility to, or the course and severity of MS in a population-based sample of 122 patients from Olmsted County. Copyright (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	189-194
Number of pages	6
Journal	Journal of neuroimmunology
Volume	105
Issue number	2
DOIs	https://doi.org/10.1016/S0165-5728(00)00198-3
State	Published - Jun 26 2000

Keywords

Genetics
Multiple sclerosis
Myeloperoxidase
Prognosis
Susceptibility

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(00)00198-3

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title = "Association of a myeloperoxidase promoter polymorphism with multiple sclerosis",

abstract = "Myeloperoxidase (MPO) generates hypochlorous acid and other reactive oxygen intermediates leading to tissue damage. MPO is expressed in macrophages-microglia in multiple sclerosis (MS) lesions. A G→A substitution that abolishes an SP1 transcription factor consensus sequence in the promoter reduces gene expression. We studied the association of the genetic variant with MS. We did not find an association with gender, age at onset, susceptibility to, or the course and severity of MS in a population-based sample of 122 patients from Olmsted County. Copyright (C) 2000 Elsevier Science B.V.",

keywords = "Genetics, Multiple sclerosis, Myeloperoxidase, Prognosis, Susceptibility",

author = "Kantarci, {Orhun H.} and Atkinson, {Elizabeth J.} and Hebrink, {David D.} and McMurray, {Cynthia T.} and Weinshenker, {Brian G.}",

note = "Funding Information: This study has been supported by the National MS Society, grant no. RG-2870-A-2. Dr. McMurray is supported by the Mayo Foundation, grant no. DK 43694-01A2 and National Institutes of Health grant no. MH-56207. Dr. Kantarci has been supported by a NATO Science Fellowship Program granted by the Scientific and Technical Research Council of Turkey and is currently supported by an advanced fellowship award from the National MS Society. Drs. S.J. London, T.A. Lehman and J.A. Taylor generously provided DNA samples of known zygosity to optimize the genotyping method.",

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doi = "10.1016/S0165-5728(00)00198-3",

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T1 - Association of a myeloperoxidase promoter polymorphism with multiple sclerosis

AU - Kantarci, Orhun H.

AU - Atkinson, Elizabeth J.

AU - Hebrink, David D.

AU - McMurray, Cynthia T.

AU - Weinshenker, Brian G.

N1 - Funding Information: This study has been supported by the National MS Society, grant no. RG-2870-A-2. Dr. McMurray is supported by the Mayo Foundation, grant no. DK 43694-01A2 and National Institutes of Health grant no. MH-56207. Dr. Kantarci has been supported by a NATO Science Fellowship Program granted by the Scientific and Technical Research Council of Turkey and is currently supported by an advanced fellowship award from the National MS Society. Drs. S.J. London, T.A. Lehman and J.A. Taylor generously provided DNA samples of known zygosity to optimize the genotyping method.

PY - 2000/6/26

Y1 - 2000/6/26

N2 - Myeloperoxidase (MPO) generates hypochlorous acid and other reactive oxygen intermediates leading to tissue damage. MPO is expressed in macrophages-microglia in multiple sclerosis (MS) lesions. A G→A substitution that abolishes an SP1 transcription factor consensus sequence in the promoter reduces gene expression. We studied the association of the genetic variant with MS. We did not find an association with gender, age at onset, susceptibility to, or the course and severity of MS in a population-based sample of 122 patients from Olmsted County. Copyright (C) 2000 Elsevier Science B.V.

AB - Myeloperoxidase (MPO) generates hypochlorous acid and other reactive oxygen intermediates leading to tissue damage. MPO is expressed in macrophages-microglia in multiple sclerosis (MS) lesions. A G→A substitution that abolishes an SP1 transcription factor consensus sequence in the promoter reduces gene expression. We studied the association of the genetic variant with MS. We did not find an association with gender, age at onset, susceptibility to, or the course and severity of MS in a population-based sample of 122 patients from Olmsted County. Copyright (C) 2000 Elsevier Science B.V.

KW - Genetics

KW - Multiple sclerosis

KW - Myeloperoxidase

KW - Prognosis

KW - Susceptibility

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Association of a myeloperoxidase promoter polymorphism with multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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