Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC)

Rosa M. Xicola; Sneha Bontu; Brian J. Doyle; Jamie Rawson; Pilar Garre; Esther Lee; Miguel De la Hoya; Xavier Bessa; Joan Clofent; Luis Bujanda; Francesc Balaguer; Sergi Castellví-Bel; Cristina Alenda; Rodrigo Jover; Clara Ruiz-Ponte; Sapna Syngal; Montserrat Andreu; Angel Carracedo; Antoni Castells; Polly A. Newcomb; Noralane Lindor; John D. Potter; John A. Baron; Nathan A. Ellis; Trinidad Caldes; Xavier L. Lor

doi:10.1093/carcin/bgw064

Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC)

Rosa M. Xicola, Sneha Bontu, Brian J. Doyle, Jamie Rawson, Pilar Garre, Esther Lee, Miguel De la Hoya, Xavier Bessa, Joan Clofent, Luis Bujanda, Francesc Balaguer, Sergi Castellví-Bel, Cristina Alenda, Rodrigo Jover, Clara Ruiz-Ponte, Sapna Syngal, Montserrat Andreu, Angel Carracedo, Antoni Castells, Polly A. NewcombNoralane Lindor, John D. Potter, John A. Baron, Nathan A. Ellis, Trinidad Caldes, Xavier L. Lor

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The purpose of this study was to identify novel colorectal cancer (CRC)-causing alleles in unexplained familial CRC cases. In order to do so, coding regions in five candidate genes (MGMT, AXIN2, CTNNB1, TGFBR1 and TGFBR2) were sequenced in 11 unrelated microsatellite-stable hereditary non-polyposis CRC (MSS HNPCC) cases. Selected genetic variants were genotyped in a discovery set of 27 MSS HNPCC cases and 85 controls. One genetic variant, rs67687202, in TGFBR1 emerged as significant (P = 0.002), and it was genotyped in a replication set of 87 additional MSS HNPCC-like cases and 338 controls where it was also significantly associated with MSS HNPCC cases (P = 0.041). In the combined genotype data, rs67687202 was associated with a moderate increase in CRC risk (OR = 1.68; 95% CI = 1.13-2.50; P = 0.010). We tested a highly correlated SNP rs868 in 723 non-familial CRC cases compared with 629 controls, and it was not significantly associated with CRC risk (P = 0.370). rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1, which might provide a functional basis for the association.

Original language	English (US)
Pages (from-to)	751-758
Number of pages	8
Journal	Carcinogenesis
Volume	37
Issue number	8
DOIs	https://doi.org/10.1093/carcin/bgw064
State	Published - Aug 1 2016

ASJC Scopus subject areas

Cancer Research

Access to Document

10.1093/carcin/bgw064

Cite this

Xicola, R. M., Bontu, S., Doyle, B. J., Rawson, J., Garre, P., Lee, E., De la Hoya, M., Bessa, X., Clofent, J., Bujanda, L., Balaguer, F., Castellví-Bel, S., Alenda, C., Jover, R., Ruiz-Ponte, C., Syngal, S., Andreu, M., Carracedo, A., Castells, A., ... Lor, X. L. (2016). Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC). Carcinogenesis, 37(8), 751-758. https://doi.org/10.1093/carcin/bgw064

Xicola, RM, Bontu, S, Doyle, BJ, Rawson, J, Garre, P, Lee, E, De la Hoya, M, Bessa, X, Clofent, J, Bujanda, L, Balaguer, F, Castellví-Bel, S, Alenda, C, Jover, R, Ruiz-Ponte, C, Syngal, S, Andreu, M, Carracedo, A, Castells, A, Newcomb, PA, Lindor, N, Potter, JD, Baron, JA, Ellis, NA, Caldes, T & Lor, XL 2016, 'Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC)', Carcinogenesis, vol. 37, no. 8, pp. 751-758. https://doi.org/10.1093/carcin/bgw064

@article{4cc490f16e3f44889c5fbc7e165d85de,

title = "Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC)",

abstract = "The purpose of this study was to identify novel colorectal cancer (CRC)-causing alleles in unexplained familial CRC cases. In order to do so, coding regions in five candidate genes (MGMT, AXIN2, CTNNB1, TGFBR1 and TGFBR2) were sequenced in 11 unrelated microsatellite-stable hereditary non-polyposis CRC (MSS HNPCC) cases. Selected genetic variants were genotyped in a discovery set of 27 MSS HNPCC cases and 85 controls. One genetic variant, rs67687202, in TGFBR1 emerged as significant (P = 0.002), and it was genotyped in a replication set of 87 additional MSS HNPCC-like cases and 338 controls where it was also significantly associated with MSS HNPCC cases (P = 0.041). In the combined genotype data, rs67687202 was associated with a moderate increase in CRC risk (OR = 1.68; 95% CI = 1.13-2.50; P = 0.010). We tested a highly correlated SNP rs868 in 723 non-familial CRC cases compared with 629 controls, and it was not significantly associated with CRC risk (P = 0.370). rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1, which might provide a functional basis for the association.",

author = "Xicola, {Rosa M.} and Sneha Bontu and Doyle, {Brian J.} and Jamie Rawson and Pilar Garre and Esther Lee and {De la Hoya}, Miguel and Xavier Bessa and Joan Clofent and Luis Bujanda and Francesc Balaguer and Sergi Castellv{\'i}-Bel and Cristina Alenda and Rodrigo Jover and Clara Ruiz-Ponte and Sapna Syngal and Montserrat Andreu and Angel Carracedo and Antoni Castells and Newcomb, {Polly A.} and Noralane Lindor and Potter, {John D.} and Baron, {John A.} and Ellis, {Nathan A.} and Trinidad Caldes and Lor, {Xavier L.}",

note = "Publisher Copyright: {\textcopyright} The Author's 2016.",

year = "2016",

month = aug,

day = "1",

doi = "10.1093/carcin/bgw064",

language = "English (US)",

volume = "37",

pages = "751--758",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC)

AU - Xicola, Rosa M.

AU - Bontu, Sneha

AU - Doyle, Brian J.

AU - Rawson, Jamie

AU - Garre, Pilar

AU - Lee, Esther

AU - De la Hoya, Miguel

AU - Bessa, Xavier

AU - Clofent, Joan

AU - Bujanda, Luis

AU - Balaguer, Francesc

AU - Castellví-Bel, Sergi

AU - Alenda, Cristina

AU - Jover, Rodrigo

AU - Ruiz-Ponte, Clara

AU - Syngal, Sapna

AU - Andreu, Montserrat

AU - Carracedo, Angel

AU - Castells, Antoni

AU - Newcomb, Polly A.

AU - Lindor, Noralane

AU - Potter, John D.

AU - Baron, John A.

AU - Ellis, Nathan A.

AU - Caldes, Trinidad

AU - Lor, Xavier L.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - The purpose of this study was to identify novel colorectal cancer (CRC)-causing alleles in unexplained familial CRC cases. In order to do so, coding regions in five candidate genes (MGMT, AXIN2, CTNNB1, TGFBR1 and TGFBR2) were sequenced in 11 unrelated microsatellite-stable hereditary non-polyposis CRC (MSS HNPCC) cases. Selected genetic variants were genotyped in a discovery set of 27 MSS HNPCC cases and 85 controls. One genetic variant, rs67687202, in TGFBR1 emerged as significant (P = 0.002), and it was genotyped in a replication set of 87 additional MSS HNPCC-like cases and 338 controls where it was also significantly associated with MSS HNPCC cases (P = 0.041). In the combined genotype data, rs67687202 was associated with a moderate increase in CRC risk (OR = 1.68; 95% CI = 1.13-2.50; P = 0.010). We tested a highly correlated SNP rs868 in 723 non-familial CRC cases compared with 629 controls, and it was not significantly associated with CRC risk (P = 0.370). rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1, which might provide a functional basis for the association.

AB - The purpose of this study was to identify novel colorectal cancer (CRC)-causing alleles in unexplained familial CRC cases. In order to do so, coding regions in five candidate genes (MGMT, AXIN2, CTNNB1, TGFBR1 and TGFBR2) were sequenced in 11 unrelated microsatellite-stable hereditary non-polyposis CRC (MSS HNPCC) cases. Selected genetic variants were genotyped in a discovery set of 27 MSS HNPCC cases and 85 controls. One genetic variant, rs67687202, in TGFBR1 emerged as significant (P = 0.002), and it was genotyped in a replication set of 87 additional MSS HNPCC-like cases and 338 controls where it was also significantly associated with MSS HNPCC cases (P = 0.041). In the combined genotype data, rs67687202 was associated with a moderate increase in CRC risk (OR = 1.68; 95% CI = 1.13-2.50; P = 0.010). We tested a highly correlated SNP rs868 in 723 non-familial CRC cases compared with 629 controls, and it was not significantly associated with CRC risk (P = 0.370). rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1, which might provide a functional basis for the association.

UR - http://www.scopus.com/inward/record.url?scp=84982938674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982938674&partnerID=8YFLogxK

U2 - 10.1093/carcin/bgw064

DO - 10.1093/carcin/bgw064

M3 - Article

C2 - 27234654

AN - SCOPUS:84982938674

SN - 0143-3334

VL - 37

SP - 751

EP - 758

JO - Carcinogenesis

JF - Carcinogenesis

IS - 8

ER -

Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC)

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this