TY - JOUR
T1 - Association between smoking and risk of primary sclerosing cholangitis
T2 - A systematic review and meta-analysis
AU - Wijarnpreecha, Karn
AU - Panjawatanan, Panadeekarn
AU - Mousa, Omar Y.
AU - Cheungpasitporn, Wisit
AU - Pungpapong, Surakit
AU - Ungprasert, Patompong
N1 - Publisher Copyright:
© 2018, © Author(s) 2018.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Background/Objectives: Studies have suggested that smokers may have a lower risk of primary sclerosing cholangitis (PSC) although the results have been inconsistent. This systematic review and meta-analysis was conducted to summarize all available data to better characterize this association. Methods: A comprehensive literature review was conducted using Medline and Embase databases through January 2018 to identify all studies that compared the risk of PSC among current/former smokers versus nonsmokers. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: Seven case-control studies with 2,307,393 participants met the eligibility criteria and were included in the meta-analysis. The risk of PSC among current smokers and former smokers was significantly lower than nonsmokers with the pooled odds ratio of 0.31 (95% CI, 0.18–0.53) and 0.52 (95% CI, 0.44–0.61), respectively. The risk remained significantly lower among current smokers and former smokers compared with nonsmokers even when only patients with PSC without inflammatory bowel disease were included. Conclusions: A significantly decreased risk of PSC among current and former smokers was demonstrated in this study.
AB - Background/Objectives: Studies have suggested that smokers may have a lower risk of primary sclerosing cholangitis (PSC) although the results have been inconsistent. This systematic review and meta-analysis was conducted to summarize all available data to better characterize this association. Methods: A comprehensive literature review was conducted using Medline and Embase databases through January 2018 to identify all studies that compared the risk of PSC among current/former smokers versus nonsmokers. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: Seven case-control studies with 2,307,393 participants met the eligibility criteria and were included in the meta-analysis. The risk of PSC among current smokers and former smokers was significantly lower than nonsmokers with the pooled odds ratio of 0.31 (95% CI, 0.18–0.53) and 0.52 (95% CI, 0.44–0.61), respectively. The risk remained significantly lower among current smokers and former smokers compared with nonsmokers even when only patients with PSC without inflammatory bowel disease were included. Conclusions: A significantly decreased risk of PSC among current and former smokers was demonstrated in this study.
KW - Primary sclerosing cholangitis
KW - cholangitis
KW - cigarettes
KW - meta-analysis
KW - smoking
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U2 - 10.1177/2050640618761703
DO - 10.1177/2050640618761703
M3 - Review article
AN - SCOPUS:85042462298
SN - 2050-6406
VL - 6
SP - 500
EP - 508
JO - United European Gastroenterology Journal
JF - United European Gastroenterology Journal
IS - 4
ER -