TY - JOUR
T1 - Association between sarcopenia and hepatic encephalopathy
T2 - A systematic review and meta-analysis
AU - Wijarnpreecha, Karn
AU - Werlang, Monia
AU - Panjawatanan, Panadeekarn
AU - Kroner, Paul T.
AU - Cheungpasitporn, Wisit
AU - Lukens, Frank J.
AU - Pungpapong, Surakit
AU - Ungprasert, Patompong
N1 - Publisher Copyright:
© 2019 Fundación Clínica Médica Sur, A.C.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Studies have suggested that the presence of sarcopenia in patients with cirrhosis could be a predisposing risk factor for hepatic encephalopathy. This systematic review and meta-analysis were conducted to summarize all available evidence on this relationship. A systematic review was carried out in Medline and EMBASE database through December 2018 to identify studies that recruited patients with cirrhosis from any causes and collected data on the presence of minimal or overt hepatic encephalopathy as well as sarcopenia. All study designs (case–control, cohort and cross-sectional studies) were eligible for the meta-analysis. Odds ratio (OR) and 95% confidence interval (CI) were extracted from the included studies and were pooled together using random-effect, generic inverse variance method of DerSimonian and Laird. Five cross-sectional studies with a total of 1,713 patients met our eligibility criteria and were included into the meta-analysis. We found a significantly higher risk of both mild and overt hepatic encephalopathy among cirrhotic patients with sarcopenia when compared with cirrhotic patients without sarcopenia with the pooled OR of 3.34 (95% CI: 1.68–6.67; I2 = 37%) and 2.05 (95% CI: 1.28–3.29; I2 = 61%), respectively. This systematic review and meta-analysis demonstrated a significant association between sarcopenia and hepatic encephalopathy among patients with cirrhosis.
AB - Studies have suggested that the presence of sarcopenia in patients with cirrhosis could be a predisposing risk factor for hepatic encephalopathy. This systematic review and meta-analysis were conducted to summarize all available evidence on this relationship. A systematic review was carried out in Medline and EMBASE database through December 2018 to identify studies that recruited patients with cirrhosis from any causes and collected data on the presence of minimal or overt hepatic encephalopathy as well as sarcopenia. All study designs (case–control, cohort and cross-sectional studies) were eligible for the meta-analysis. Odds ratio (OR) and 95% confidence interval (CI) were extracted from the included studies and were pooled together using random-effect, generic inverse variance method of DerSimonian and Laird. Five cross-sectional studies with a total of 1,713 patients met our eligibility criteria and were included into the meta-analysis. We found a significantly higher risk of both mild and overt hepatic encephalopathy among cirrhotic patients with sarcopenia when compared with cirrhotic patients without sarcopenia with the pooled OR of 3.34 (95% CI: 1.68–6.67; I2 = 37%) and 2.05 (95% CI: 1.28–3.29; I2 = 61%), respectively. This systematic review and meta-analysis demonstrated a significant association between sarcopenia and hepatic encephalopathy among patients with cirrhosis.
KW - Frailty
KW - Hepatic encephalopathy
KW - Meta-analysis
KW - Sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=85083780524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083780524&partnerID=8YFLogxK
U2 - 10.1016/j.aohep.2019.06.007
DO - 10.1016/j.aohep.2019.06.007
M3 - Review article
C2 - 31422030
AN - SCOPUS:85083780524
SN - 1665-2681
VL - 19
SP - 245
EP - 250
JO - Annals of hepatology
JF - Annals of hepatology
IS - 3
ER -