Association between response rates and survival outcomes in patients with newly diagnosed multiple myeloma. A systematic review and meta-regression analysis

Maria Mainou, Anastasia Vasiliki Madenidou, Aris Liakos, Paschalis Paschos, Thomas Karagiannis, Eleni Bekiari, Efthymia Vlachaki, Zhen Wang, Mohammad Hassan Murad, Shaji Kumar, Apostolos Tsapas

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Objectives: We performed a systematic review and meta-regression analysis of randomized control trials to investigate the association between response to initial treatment and survival outcomes in patients with newly diagnosed multiple myeloma (MM). Methods: Response outcomes included complete response (CR) and the combined outcome of CR or very good partial response (VGPR), while survival outcomes were overall survival (OS) and progression-free survival (PFS). We used random-effect meta-regression models and conducted sensitivity analyses based on definition of CR and study quality. Results: Seventy-two trials were included in the systematic review, 63 of which contributed data in meta-regression analyses. There was no association between OS and CR in patients without autologous stem cell transplant (ASCT) (regression coefficient:.02, 95% confidence interval [CI] −0.06, 0.10), in patients undergoing ASCT (−.11, 95% CI −0.44, 0.22) and in trials comparing ASCT with non-ASCT patients (.04, 95% CI −0.29, 0.38). Similarly, OS did not correlate with the combined metric of CR or VGPR, and no association was evident between response outcomes and PFS. Sensitivity analyses yielded similar results. Conclusions: This meta-regression analysis suggests that there is no association between conventional response outcomes and survival in patients with newly diagnosed MM.

Original languageEnglish (US)
Pages (from-to)563-568
Number of pages6
JournalEuropean Journal of Haematology
Volume98
Issue number6
DOIs
StatePublished - Jun 2017

Keywords

  • complete response
  • meta-regression analysis
  • multiple myeloma
  • survival
  • systematic review

ASJC Scopus subject areas

  • Hematology

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