TY - JOUR
T1 - Association between race and survival of patients with non-small-cell lung cancer in the united states veterans affairs population
AU - Ganti, Apar Kishor
AU - Subbiah, Shanmuga P.
AU - Kessinger, Anne
AU - Gonsalves, Wilson I.
AU - Silberstein, Peter T.
AU - Loberiza, Fausto R.
PY - 2014/3
Y1 - 2014/3
N2 - Background Racial disparities in outcomes of non-small-cell lung cancer (NSCLC) patients in the United States are well documented. A retrospective analysis of patients in the Veterans Affairs Central Cancer Registry was conducted to determine whether similar disparities exist in a population with a single-payer, accessible health care system. Patients and Methods Demographic data of patients diagnosed with NSCLC between January 1995 and February 2009 were analyzed using Kruskal-Wallis test or the χ2 test. Multivariate Cox proportional hazards regression analysis was used to compare survival among races. Results Of the 82,414 patients, 98% were male, 82% had a smoking history, and 81% were Caucasian. Caucasian individuals had better prognostic features compared with African-American individuals (stage I/II [24% vs. 21%]; Grade I/II [21% vs. 17%]). A larger proportion of Caucasian compared with African-American individuals received stage-appropriate treatment (surgery for stage I [48% vs. 41%; P <.001]; chemotherapy for stage IV [18% vs. 16%; P =.003]). African-American individuals had a lower risk of mortality compared with Caucasian individuals (hazard ratio, 0.94; 95% confidence interval, 0.92-0.96). Conclusion Although African-American patients had a higher stage and grade of NSCLC, they had a better overall survival than Caucasian patients. In a single-payer system with accessible health care, previously described racial differences in lung cancer outcomes were not observed.
AB - Background Racial disparities in outcomes of non-small-cell lung cancer (NSCLC) patients in the United States are well documented. A retrospective analysis of patients in the Veterans Affairs Central Cancer Registry was conducted to determine whether similar disparities exist in a population with a single-payer, accessible health care system. Patients and Methods Demographic data of patients diagnosed with NSCLC between January 1995 and February 2009 were analyzed using Kruskal-Wallis test or the χ2 test. Multivariate Cox proportional hazards regression analysis was used to compare survival among races. Results Of the 82,414 patients, 98% were male, 82% had a smoking history, and 81% were Caucasian. Caucasian individuals had better prognostic features compared with African-American individuals (stage I/II [24% vs. 21%]; Grade I/II [21% vs. 17%]). A larger proportion of Caucasian compared with African-American individuals received stage-appropriate treatment (surgery for stage I [48% vs. 41%; P <.001]; chemotherapy for stage IV [18% vs. 16%; P =.003]). African-American individuals had a lower risk of mortality compared with Caucasian individuals (hazard ratio, 0.94; 95% confidence interval, 0.92-0.96). Conclusion Although African-American patients had a higher stage and grade of NSCLC, they had a better overall survival than Caucasian patients. In a single-payer system with accessible health care, previously described racial differences in lung cancer outcomes were not observed.
KW - Non-small-cell lung cancer
KW - Outcomes
KW - Prognosis
KW - Race
KW - Survival
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U2 - 10.1016/j.cllc.2013.11.004
DO - 10.1016/j.cllc.2013.11.004
M3 - Article
C2 - 24361249
AN - SCOPUS:84894052887
SN - 1525-7304
VL - 15
SP - 152
EP - 158
JO - Clinical lung cancer
JF - Clinical lung cancer
IS - 2
ER -