Association between quality of life and clinical parameters in patients with myeloproliferative neoplasms

Peter Johansson, Ruben Mesa, Robyn Scherber, Johanna Abelsson, Jan Samuelsson, Gunnar Birgegård, Björn Andréasson

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) is a validated quality of life (QoL) instrument. In our Swedish cohort of 114 patients the symptomatic burden was found to be severe, with fatigue reported in 88% of the patients and reduced QoL in the majority of patients. Patients with primary myelofibrosis had the highest scores, low QoL, for most MPN-SAF items, compared to patients with polycythemia vera and essential thrombocythemia. Higher age showed significant associations with the BFI (Brief Fatigue Inventory) score, early satiety, concentration problems, dizziness, insomnia, cough and weight loss. Blood values, disease duration and myelosuppressive treatment did not significantly associate with any of the MPN-SAF items, with the exception of higher hemoglobin, which correlated with sad mood. Male patients with MPN scored significantly higher as regards sexual problems and weight loss compared to female patients. Overall, the MPN-SAF was found to be a valid instrument for assessing symptomatic burden among this population.

Original languageEnglish (US)
Pages (from-to)441-444
Number of pages4
JournalLeukemia and Lymphoma
Volume53
Issue number3
DOIs
StatePublished - Mar 1 2012

Keywords

  • Myeloproliferative neoplasms
  • Quality of life

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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