Association between programmed death-Ligand 1 expression and the vascular endothelial growth factor pathway in angiosarcoma

Sanjay P. Bagaria, Zoran Gatalica, Todd Maney, Daniel Serie, Mansi Parasramka, Steven Attia, Murli Krishna, Richard W. Joseph

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Angiosarcoma is a vascular malignancy associated with a poor prognosis and chemotherapy resistance. The tumor immune microenvironment of angiosarcoma has not been characterized. We investigated the expression of programmed death-ligand 1 (PD-L1) and programmed death 1 (PD-1) in angiosarcoma and correlated these findings with vascular endothelial growth factor (VEGF)-related gene expression and survival. Using archived formalin-fixed paraffin-embedded tissues of primary and metastatic angiosarcoma specimens, we characterized the immunohistochemical (IHC) expression of PD-L1 and PD-1. In addition, we extracted RNA from each tumor and quantified the expression of VEGF-related genes, and then tested if these genes were associated with PD-L1 and PD-1 expression and clinical outcomes. Retrospective review identified 27 angiosarcoma specimens collected between 1994 and 2012. IHC expression of tumor PD-L1, tumor-infiltrating immune cell PD-L1, and tumor-infiltrating immune cell PD-1 expression was identified in 5 (19%), 9 (33%), and 1 (4%) specimens, respectively. Expression of PD-L1 and PD-1 was not associated with VEGF-related gene expression or survival. PD-L1 tumor and tumor-infiltrating immune cells expression was identified in a large proportion of patients. Though neither was associated with VEGF-related gene expression or prognosis, targeting PD-1/PD-L1 may be of benefit for a significant proportion of angiosarcomas that do not respond to surgery, chemotherapy, or radiation.

Original languageEnglish (US)
Article number71
JournalFrontiers in Oncology
Volume8
Issue numberMAR
DOIs
StatePublished - Mar 22 2018

Keywords

  • Angiosarcoma
  • Checkpoint pathway
  • Immune microenvironment
  • Programmed death-ligand 1
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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