Association between PRODH and schizophrenia is not confirmed

H. J. Williams, N. Williams, G. Spurlock, N. Norton, D. Ivanov, R. G. McCreadie, A. Preece, V. Sharkey, S. Jones, S. Zammit, I. Nikolov, I. Kehaiov, A. Thapar, K. C. Murphy, G. Kirov, M. J. Owen, M. C. O'Donovan

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Previous studies show that genetic variation within the proline dehydrogenase gene (PRODH) increases risk of developing schizophrenia. This is of particular interest since PRODH maps to chromosome 22q11, deletion of which is a strong risk factor for schizophrenia. The authors examined this claim using samples with power of ∼0.99, but failed to obtain evidence in support of the hypothesis. Given the high power to replicate the previous findings, the data suggest that genetic variation in PRODH is unlikely to be associated with increased risk of schizophrenia.

Original languageEnglish (US)
Pages (from-to)644-645+641
JournalMolecular Psychiatry
Issue number7
StatePublished - Aug 21 2003

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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    Williams, H. J., Williams, N., Spurlock, G., Norton, N., Ivanov, D., McCreadie, R. G., Preece, A., Sharkey, V., Jones, S., Zammit, S., Nikolov, I., Kehaiov, I., Thapar, A., Murphy, K. C., Kirov, G., Owen, M. J., & O'Donovan, M. C. (2003). Association between PRODH and schizophrenia is not confirmed. Molecular Psychiatry, 8(7), 644-645+641.