Association between plasma adiponectin levels and unstable coronary syndromes

Robert Wolk, Peter Berger, Ryan J. Lennon, Emmanouil S. Brilakis, Diane E. Davison, Virend K. Somers

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

Aims: Obesity is a risk factor for an acute coronary syndrome (ACS). The association between elevated body mass index (BMI) and ACS is independent of most traditional risk factors, suggesting a possible contribution of other body fat-related mediators. This study evaluated the association between adiponectin and ACS. Methods and results: Four hundred and ninety-nine patients undergoing coronary angiography were divided into a subgroup without (n = 331) and with ACS (n = 168). In multiple regression analysis, higher adiponectin levels were independently associated with a lower risk of ACS [odds ratio (OR) = 0.61; 95% CIs: 0.46-0.81; P < 0.001]. In contrast, a higher BMI, a history of myocardial infarction, C-reactive protein, and angiographic coronary artery disease severity were all associated with a higher risk. The greatest increase in risk for ACS was seen at adiponectin levels ≤ 5.5 μg/mL. Conclusion: Higher plasma adiponectin levels are independently associated with a lower risk of ACS.

Original languageEnglish (US)
Pages (from-to)292-298
Number of pages7
JournalEuropean heart journal
Volume28
Issue number3
DOIs
StatePublished - Feb 2007

Keywords

  • Acute coronary syndrome
  • Adipokines
  • Adiponectin
  • Angiography
  • Atherosclerosis
  • C-reactive protein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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