Association between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging

Janina Krell-Roesch; Jeremy A. Syrjanen; Michelle M. Mielke; Teresa J. Christianson; Walter K. Kremers; Mary M. MacHulda; David S. Knopman; Ronald C. Petersen; Maria Vassilaki; Yonas E. Geda

doi:10.3233/JAD-200764

Association between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging

Janina Krell-Roesch, Jeremy A. Syrjanen, Michelle M. Mielke, Teresa J. Christianson, Walter K. Kremers, Mary M. MacHulda, David S. Knopman, Ronald C. Petersen, Maria Vassilaki, Yonas E. Geda

Research output: Contribution to journal › Article › peer-review

Abstract

We examined the associations between baseline neuropsychiatric symptoms (NPS) and longitudinal changes in functional performance among 5,394 non-demented individuals aged ≥50 years (2,729 males; median age 74.2 years; 4,716 cognitively unimpaired, 678 mild cognitive impairment). After adjusting for age, sex, education, and medical comorbidities, NPS assessed by the Neuropsychiatric Inventory Questionnaire, clinical depression (Beck Depression Inventory score ≥13) and anxiety (Beck Anxiety Inventory score ≥10) were significantly associated with an increase in the Functional Activities Questionnaire score, indicating functional decline over time. This association may vary depending on the degree of cognitive impairment at baseline.

Original language	English (US)
Pages (from-to)	911-917
Number of pages	7
Journal	Journal of Alzheimer's Disease
Volume	78
Issue number	3
DOIs	https://doi.org/10.3233/JAD-200764
State	Published - 2020

Keywords

Anxiety
depression
functional performance

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-200764

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Krell-Roesch, J., Syrjanen, J. A., Mielke, M. M., Christianson, T. J., Kremers, W. K., MacHulda, M. M., Knopman, D. S., Petersen, R. C., Vassilaki, M., & Geda, Y. E. (2020). Association between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging. Journal of Alzheimer's Disease, 78(3), 911-917. https://doi.org/10.3233/JAD-200764

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abstract = "We examined the associations between baseline neuropsychiatric symptoms (NPS) and longitudinal changes in functional performance among 5,394 non-demented individuals aged ≥50 years (2,729 males; median age 74.2 years; 4,716 cognitively unimpaired, 678 mild cognitive impairment). After adjusting for age, sex, education, and medical comorbidities, NPS assessed by the Neuropsychiatric Inventory Questionnaire, clinical depression (Beck Depression Inventory score ≥13) and anxiety (Beck Anxiety Inventory score ≥10) were significantly associated with an increase in the Functional Activities Questionnaire score, indicating functional decline over time. This association may vary depending on the degree of cognitive impairment at baseline.",

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AU - Mielke, Michelle M.

AU - Christianson, Teresa J.

AU - Kremers, Walter K.

AU - MacHulda, Mary M.

AU - Knopman, David S.

AU - Petersen, Ronald C.

AU - Vassilaki, Maria

AU - Geda, Yonas E.

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Association between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging

Abstract

Keywords

ASJC Scopus subject areas

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