Association between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging

Janina Krell-Roesch, Jeremy A. Syrjanen, Michelle M. Mielke, Teresa J. Christianson, Walter K. Kremers, Mary M. MacHulda, David S. Knopman, Ronald C. Petersen, Maria Vassilaki, Yonas E. Geda

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the associations between baseline neuropsychiatric symptoms (NPS) and longitudinal changes in functional performance among 5,394 non-demented individuals aged ≥50 years (2,729 males; median age 74.2 years; 4,716 cognitively unimpaired, 678 mild cognitive impairment). After adjusting for age, sex, education, and medical comorbidities, NPS assessed by the Neuropsychiatric Inventory Questionnaire, clinical depression (Beck Depression Inventory score ≥13) and anxiety (Beck Anxiety Inventory score ≥10) were significantly associated with an increase in the Functional Activities Questionnaire score, indicating functional decline over time. This association may vary depending on the degree of cognitive impairment at baseline.

Original languageEnglish (US)
Pages (from-to)911-917
Number of pages7
JournalJournal of Alzheimer's Disease
Volume78
Issue number3
DOIs
StatePublished - 2020

Keywords

  • Anxiety
  • depression
  • functional performance

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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