Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis

Natalie L. Berntsen, Olav Klingenberg, Brian D. Juran, Maria Benito De Valle, Björn Lindkvist, Konstantinos N Lazaridis, Kirsten Muri Boberg, Tom H. Karlsen, Johannes Roksund Hov

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B∗08, than patients without increased IgG4, and significantly higher frequencies of HLA-B∗07 and HLA-DRB1∗15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.

Original languageEnglish (US)
Pages (from-to)924-927.e2
JournalGastroenterology
Volume148
Issue number5
DOIs
StatePublished - May 1 2015
Externally publishedYes

Keywords

  • Genetic Association Study
  • IgG4-Associated Cholangitis
  • Immune Response
  • Immunogenetics

ASJC Scopus subject areas

  • Gastroenterology

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    Berntsen, N. L., Klingenberg, O., Juran, B. D., Benito De Valle, M., Lindkvist, B., Lazaridis, K. N., Boberg, K. M., Karlsen, T. H., & Hov, J. R. (2015). Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis. Gastroenterology, 148(5), 924-927.e2. https://doi.org/10.1053/j.gastro.2015.01.041