Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis

Natalie L. Berntsen, Olav Klingenberg, Brian D. Juran, Maria Benito De Valle, Björn Lindkvist, Konstantinos N Lazaridis, Kirsten Muri Boberg, Tom H. Karlsen, Johannes Roksund Hov

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B∗08, than patients without increased IgG4, and significantly higher frequencies of HLA-B∗07 and HLA-DRB1∗15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.

Original languageEnglish (US)
Pages (from-to)924-927.e2
JournalGastroenterology
Volume148
Issue number5
DOIs
StatePublished - May 1 2015
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Haplotypes
Immunoglobulin G
Serum
Norway
Sweden
Genotype
Phenotype

Keywords

  • Genetic Association Study
  • IgG4-Associated Cholangitis
  • Immune Response
  • Immunogenetics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Berntsen, N. L., Klingenberg, O., Juran, B. D., Benito De Valle, M., Lindkvist, B., Lazaridis, K. N., ... Hov, J. R. (2015). Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis. Gastroenterology, 148(5), 924-927.e2. https://doi.org/10.1053/j.gastro.2015.01.041

Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis. / Berntsen, Natalie L.; Klingenberg, Olav; Juran, Brian D.; Benito De Valle, Maria; Lindkvist, Björn; Lazaridis, Konstantinos N; Boberg, Kirsten Muri; Karlsen, Tom H.; Hov, Johannes Roksund.

In: Gastroenterology, Vol. 148, No. 5, 01.05.2015, p. 924-927.e2.

Research output: Contribution to journalArticle

Berntsen, NL, Klingenberg, O, Juran, BD, Benito De Valle, M, Lindkvist, B, Lazaridis, KN, Boberg, KM, Karlsen, TH & Hov, JR 2015, 'Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis', Gastroenterology, vol. 148, no. 5, pp. 924-927.e2. https://doi.org/10.1053/j.gastro.2015.01.041
Berntsen, Natalie L. ; Klingenberg, Olav ; Juran, Brian D. ; Benito De Valle, Maria ; Lindkvist, Björn ; Lazaridis, Konstantinos N ; Boberg, Kirsten Muri ; Karlsen, Tom H. ; Hov, Johannes Roksund. / Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis. In: Gastroenterology. 2015 ; Vol. 148, No. 5. pp. 924-927.e2.
@article{ed0fb76d39084272a8bffe7efa56761e,
title = "Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis",
abstract = "Increased serum levels of IgG4 have been reported in 9{\%}-15{\%} of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B∗08, than patients without increased IgG4, and significantly higher frequencies of HLA-B∗07 and HLA-DRB1∗15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.",
keywords = "Genetic Association Study, IgG4-Associated Cholangitis, Immune Response, Immunogenetics",
author = "Berntsen, {Natalie L.} and Olav Klingenberg and Juran, {Brian D.} and {Benito De Valle}, Maria and Bj{\"o}rn Lindkvist and Lazaridis, {Konstantinos N} and Boberg, {Kirsten Muri} and Karlsen, {Tom H.} and Hov, {Johannes Roksund}",
year = "2015",
month = "5",
day = "1",
doi = "10.1053/j.gastro.2015.01.041",
language = "English (US)",
volume = "148",
pages = "924--927.e2",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "5",

}

TY - JOUR

T1 - Association between HLA haplotypes and increased serum levels of IgG4 in patients with primary sclerosing cholangitis

AU - Berntsen, Natalie L.

AU - Klingenberg, Olav

AU - Juran, Brian D.

AU - Benito De Valle, Maria

AU - Lindkvist, Björn

AU - Lazaridis, Konstantinos N

AU - Boberg, Kirsten Muri

AU - Karlsen, Tom H.

AU - Hov, Johannes Roksund

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B∗08, than patients without increased IgG4, and significantly higher frequencies of HLA-B∗07 and HLA-DRB1∗15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.

AB - Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B∗08, than patients without increased IgG4, and significantly higher frequencies of HLA-B∗07 and HLA-DRB1∗15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.

KW - Genetic Association Study

KW - IgG4-Associated Cholangitis

KW - Immune Response

KW - Immunogenetics

UR - http://www.scopus.com/inward/record.url?scp=84928625736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928625736&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2015.01.041

DO - 10.1053/j.gastro.2015.01.041

M3 - Article

VL - 148

SP - 924-927.e2

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 5

ER -