Abstract
Background/objectives: Recent studies have suggested an association between nonalcoholic fatty liver disease (NAFLD) and diastolic cardiac dysfunction, although the results were inconsistent. This study was conducted to investigate this possible association. Methods: A comprehensive literature review was conducted utilizing the MEDLINE and Embase databases from inception through May 2018 to identify all cross-sectional studies that compared the prevalence of diastolic cardiac dysfunction among patients with NAFLD to individuals without NAFLD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of 12 studies with 280,645 participants fulfilled the eligibility criteria and were included in the meta-analysis. There was a significant association between NAFLD and diastolic cardiac dysfunction with a pooled odds ratio (OR) of 2.02 (95% confidence interval (CI), 1.47–2.79; I2 89%). Subgroup analysis based on the country of origin continued to demonstrate a significant association in subgroups of both Western and Eastern countries with pooled ORs of 1.76 (95% CI, 1.14–2.72; I2 85%) and 2.59 (95% CI, 1.42–4.69; I2 87%), respectively. Limitations included high between-study heterogeneity, lack of unified definition of diastolic dysfunction and presence of publication bias. Conclusions: A significant association between diastolic cardiac dysfunction and NAFLD was observed in this meta-analysis. This observation could suggest the need for careful cardiovascular surveillance among patients with NAFLD.
| Original language | English (US) |
|---|---|
| Journal | Digestive and Liver Disease |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- Diastolic heart failure
- Heart failure with preserved ejection fraction
- Meta-analysis
- Nonalcoholic fatty liver disease
- Nonalcoholic steatohepatitis
ASJC Scopus subject areas
- Hepatology
- Gastroenterology
Cite this
Association between diastolic cardiac dysfunction and nonalcoholic fatty liver disease : A systematic review and meta-analysis. / Wijarnpreecha, Karn; Lou, Susan; Panjawatanan, Panadeekarn; Cheungpasitporn, Wisit; Pungpapong, Surakit; Lukens, Frank J.; Ungprasert, Patompong.
In: Digestive and Liver Disease, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association between diastolic cardiac dysfunction and nonalcoholic fatty liver disease
T2 - A systematic review and meta-analysis
AU - Wijarnpreecha, Karn
AU - Lou, Susan
AU - Panjawatanan, Panadeekarn
AU - Cheungpasitporn, Wisit
AU - Pungpapong, Surakit
AU - Lukens, Frank J.
AU - Ungprasert, Patompong
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background/objectives: Recent studies have suggested an association between nonalcoholic fatty liver disease (NAFLD) and diastolic cardiac dysfunction, although the results were inconsistent. This study was conducted to investigate this possible association. Methods: A comprehensive literature review was conducted utilizing the MEDLINE and Embase databases from inception through May 2018 to identify all cross-sectional studies that compared the prevalence of diastolic cardiac dysfunction among patients with NAFLD to individuals without NAFLD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of 12 studies with 280,645 participants fulfilled the eligibility criteria and were included in the meta-analysis. There was a significant association between NAFLD and diastolic cardiac dysfunction with a pooled odds ratio (OR) of 2.02 (95% confidence interval (CI), 1.47–2.79; I2 89%). Subgroup analysis based on the country of origin continued to demonstrate a significant association in subgroups of both Western and Eastern countries with pooled ORs of 1.76 (95% CI, 1.14–2.72; I2 85%) and 2.59 (95% CI, 1.42–4.69; I2 87%), respectively. Limitations included high between-study heterogeneity, lack of unified definition of diastolic dysfunction and presence of publication bias. Conclusions: A significant association between diastolic cardiac dysfunction and NAFLD was observed in this meta-analysis. This observation could suggest the need for careful cardiovascular surveillance among patients with NAFLD.
AB - Background/objectives: Recent studies have suggested an association between nonalcoholic fatty liver disease (NAFLD) and diastolic cardiac dysfunction, although the results were inconsistent. This study was conducted to investigate this possible association. Methods: A comprehensive literature review was conducted utilizing the MEDLINE and Embase databases from inception through May 2018 to identify all cross-sectional studies that compared the prevalence of diastolic cardiac dysfunction among patients with NAFLD to individuals without NAFLD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of 12 studies with 280,645 participants fulfilled the eligibility criteria and were included in the meta-analysis. There was a significant association between NAFLD and diastolic cardiac dysfunction with a pooled odds ratio (OR) of 2.02 (95% confidence interval (CI), 1.47–2.79; I2 89%). Subgroup analysis based on the country of origin continued to demonstrate a significant association in subgroups of both Western and Eastern countries with pooled ORs of 1.76 (95% CI, 1.14–2.72; I2 85%) and 2.59 (95% CI, 1.42–4.69; I2 87%), respectively. Limitations included high between-study heterogeneity, lack of unified definition of diastolic dysfunction and presence of publication bias. Conclusions: A significant association between diastolic cardiac dysfunction and NAFLD was observed in this meta-analysis. This observation could suggest the need for careful cardiovascular surveillance among patients with NAFLD.
KW - Diastolic heart failure
KW - Heart failure with preserved ejection fraction
KW - Meta-analysis
KW - Nonalcoholic fatty liver disease
KW - Nonalcoholic steatohepatitis
UR - http://www.scopus.com/inward/record.url?scp=85054135254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054135254&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2018.09.004
DO - 10.1016/j.dld.2018.09.004
M3 - Article
C2 - 30292566
AN - SCOPUS:85054135254
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
ER -