Association between atopic dermatitis and squamous cell carcinoma: A case-control study

Janice M. Cho, Dawn Marie R. Davis, David A. Wetter, Adam C. Bartley, Jerry D. Brewer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Conflicting data have been published on whether an association exists between atopic dermatitis (AD) and nonmelanoma skin cancer. This study aimed to determine whether individuals with AD had an increased risk of squamous cell carcinoma (SCC) development. Methods: We conducted a retrospective, case-control study of patients residing in Olmsted County, Minnesota. Cases were selected from patients seen at Mayo Clinic (Rochester, Minnesota) who had an initial SCC diagnosis (either invasive SCC or SCC in situ) from January 1, 1996, through December 23, 2010. Age- and sex-matched controls were selected from patients seen at Mayo Clinic with no history of SCC before the case event date. Results: Three hundred ninety-nine individuals with a documented history of SCC were identified and matched with 780 controls who did not have a history of SCC. After adjusting for race, smoking history, ionizing radiation exposure, corticosteroid and cyclosporine use, and non-SCC skin cancers, the odds ratio for SCC development between patients with history of AD versus patients without history of AD was 1.75 (95% CI, 1.05-2.93). Conclusions: Our findings support an increased risk of SCC development in the setting of AD.

Original languageEnglish (US)
JournalInternational Journal of Dermatology
DOIs
StateAccepted/In press - Jan 1 2017

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Atopic Dermatitis
Case-Control Studies
Squamous Cell Carcinoma
Skin Neoplasms
Carcinoma in Situ
Ionizing Radiation
Cyclosporine
Adrenal Cortex Hormones
Smoking
History
Odds Ratio
Carcinoma

ASJC Scopus subject areas

  • Dermatology

Cite this

Association between atopic dermatitis and squamous cell carcinoma : A case-control study. / Cho, Janice M.; Davis, Dawn Marie R.; Wetter, David A.; Bartley, Adam C.; Brewer, Jerry D.

In: International Journal of Dermatology, 01.01.2017.

Research output: Contribution to journalArticle

Cho, Janice M. ; Davis, Dawn Marie R. ; Wetter, David A. ; Bartley, Adam C. ; Brewer, Jerry D. / Association between atopic dermatitis and squamous cell carcinoma : A case-control study. In: International Journal of Dermatology. 2017.
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