TY - JOUR
T1 - Association between appendectomy and risk of primary sclerosing cholangitis
T2 - A systematic review and meta-analysis
AU - Wijarnpreecha, Karn
AU - Panjawatanan, Panadeekarn
AU - Mousa, Omar Y.
AU - Cheungpasitporn, Wisit
AU - Pungpapong, Surakit
AU - Ungprasert, Patompong
N1 - Publisher Copyright:
© 2018 Elsevier Masson SAS
PY - 2018/10
Y1 - 2018/10
N2 - Background/objectives: Recent epidemiologic studies have suggested that appendectomy could be a risk factor for primary sclerosing cholangitis (PSC) although the results were inconsistent. This systematic review and meta-analysis was conducted to summarize all available evidence. Methods: A comprehensive literature review was conducted using MEDLINE and EMBASE database through January 2018 to identify all studies that reported the risk of PSC among individuals who had appendectomy versus those with no history of appendectomy. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of 6 case-control studies with 2432 participants met the eligibility criteria and were included in the meta-analysis. The risk of PSC in individuals who had appendectomy was significantly higher than those with no history of appendectomy with the pooled odds ratio of 1.37 (95% CI: 1.15–1.63). The statistical heterogeneity was insignificant with an I2 of 0%. Conclusions: A significantly increased risk of PSC among individuals who had a history of appendectomy was found in this study.
AB - Background/objectives: Recent epidemiologic studies have suggested that appendectomy could be a risk factor for primary sclerosing cholangitis (PSC) although the results were inconsistent. This systematic review and meta-analysis was conducted to summarize all available evidence. Methods: A comprehensive literature review was conducted using MEDLINE and EMBASE database through January 2018 to identify all studies that reported the risk of PSC among individuals who had appendectomy versus those with no history of appendectomy. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of 6 case-control studies with 2432 participants met the eligibility criteria and were included in the meta-analysis. The risk of PSC in individuals who had appendectomy was significantly higher than those with no history of appendectomy with the pooled odds ratio of 1.37 (95% CI: 1.15–1.63). The statistical heterogeneity was insignificant with an I2 of 0%. Conclusions: A significantly increased risk of PSC among individuals who had a history of appendectomy was found in this study.
KW - Appendectomy
KW - Appendix
KW - Meta-analysis
KW - Primary sclerosing cholangitis
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U2 - 10.1016/j.clinre.2018.03.011
DO - 10.1016/j.clinre.2018.03.011
M3 - Article
C2 - 29655526
AN - SCOPUS:85045240289
SN - 2210-7401
VL - 42
SP - 436
EP - 442
JO - Clinics and Research in Hepatology and Gastroenterology
JF - Clinics and Research in Hepatology and Gastroenterology
IS - 5
ER -