Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose

Frank Schraml, Kewei Chen, Napatkamon Ayutyanont, Roontiva Auttawut, Jessica B.S. Langbaum, Wendy Lee, Xiaofen Liu, Dan Bandy, Stephanie Q. Reeder, Gene E. Alexander, Richard J. Caselli, Adam S. Fleisher, Eric M. Reiman

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background:We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.Methods:An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.Results:These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).Conclusions:The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD.

Original languageEnglish (US)
Article numbere67163
JournalPloS one
Issue number6
StatePublished - Jun 26 2013

ASJC Scopus subject areas

  • General


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