Association between a promoter variant in the monoamine oxidase A gene and schizophrenia

Erik G. Jönsson, Nadine Norton, Kaj Forslund, Marja Mattila-Evenden, Gunnar Rylander, Marie Åsberg, Michael J. Owen, Göran C. Sedvall

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Monoaminergic transmission has been implicated in the pathophysiology of schizophrenia. We investigated a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene in schizophrenic patients (n = 133) and control subjects (n = 377). In men, there was an association between the less efficiently transcribed alleles and schizophrenia (χ2 = 4.01, df = 1, p < 0.05). In women, no significant differences were found. The present results support the involvement of the MAOA gene in men with schizophrenia in the investigated Swedish population but should be interpreted with caution until replicated.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalSchizophrenia Research
Volume61
Issue number1
DOIs
StatePublished - May 1 2003

Keywords

  • Association
  • Genetics
  • Monoamine oxidase A (MAOA) gene
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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