Abstract
Monoaminergic transmission has been implicated in the pathophysiology of schizophrenia. We investigated a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene in schizophrenic patients (n = 133) and control subjects (n = 377). In men, there was an association between the less efficiently transcribed alleles and schizophrenia (χ2 = 4.01, df = 1, p < 0.05). In women, no significant differences were found. The present results support the involvement of the MAOA gene in men with schizophrenia in the investigated Swedish population but should be interpreted with caution until replicated.
Original language | English (US) |
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Pages (from-to) | 31-37 |
Number of pages | 7 |
Journal | Schizophrenia Research |
Volume | 61 |
Issue number | 1 |
DOIs | |
State | Published - May 1 2003 |
Keywords
- Association
- Genetics
- Monoamine oxidase A (MAOA) gene
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry