Association and linkage analysis of the α-adducin gene and blood pressure

Molly S. Bray, Li Li, Stephen T Turner, Sharon L R Kardia, Eric Boerwinkle

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

In Milan hypertensive rats, a variant in the α-adducin gene has been shown to account for approximately 50% of the interindividual variation in blood pressure levels between these animals and their normotensive counterparts. Additional studies have suggested that a polymorphism within exon 10 of the human α-adducin gene (Gly-460-Trp) may be associated with hypertension and salt sensitivity. On the basis of these observations, we investigated variation within or near the human α-adducin gene for linkage and association with a locus influencing blood pressure levels in 281 nuclear families (774 siblings aged 5 to 37 years; 380 parents aged 26 to 57 years), selected from the white population of Rochester, Minnesota, without regard to health. Sib pair linkage analyses (n = 852 sibling pairs) using a dinucleotide repeat marker (D4S43) that maps approximately 660 kb from the α-adducin gene provided no evidence of linkage between this marker locus and a locus influencing systolic, diastolic, or mean blood pressure levels. Allele frequencies for the Gly-460-Trp polymorphism were similar to those reported in other white populations (Gly = 0.812, Trp = 0.188); however, this polymorphism was not associated with any measure of blood pressure level in either parents or siblings. Therefore, variation within the α-adducin gene does not appear to have a major influence on measures of blood pressure in white families from Rochester, Minnesota. (C) 2000 American Journal of Hypertension, Ltd.

Original languageEnglish (US)
Pages (from-to)699-703
Number of pages5
JournalAmerican Journal of Hypertension
Volume13
Issue number6 I
DOIs
StatePublished - 2000

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Blood Pressure
Siblings
Genes
Parents
Dinucleotide Repeats
Nuclear Family
Gene Frequency
Population
Exons
Salts
adducin
Hypertension
Health

Keywords

  • Family
  • Genetics
  • Hypertension
  • Polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association and linkage analysis of the α-adducin gene and blood pressure. / Bray, Molly S.; Li, Li; Turner, Stephen T; Kardia, Sharon L R; Boerwinkle, Eric.

In: American Journal of Hypertension, Vol. 13, No. 6 I, 2000, p. 699-703.

Research output: Contribution to journalArticle

Bray, Molly S. ; Li, Li ; Turner, Stephen T ; Kardia, Sharon L R ; Boerwinkle, Eric. / Association and linkage analysis of the α-adducin gene and blood pressure. In: American Journal of Hypertension. 2000 ; Vol. 13, No. 6 I. pp. 699-703.
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