Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

Pamela Sklar, Sibylle G. Schwab, Nigel M. Williams, Mark Daly, Stephen Schaffner, Wolfgang Maier, Margot Albus, Matyas Trixler, Peter Eichhammer, Bernard Lerer, Joachim Hallmayer, Nadine Norton, Hywel Williams, Stan Zammit, Alastair G. Cardno, Sue Jones, Geraldine McCarthy, Vihra Milanova, George Kirov, Michael C. O'DonovanEric S. Lander, Michael J. Owen, Dieter B. Wildenauer

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Abstract

A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

Original languageEnglish (US)
Pages (from-to)126-128
Number of pages3
JournalNature Genetics
Volume28
Issue number2
DOIs
StatePublished - Jun 26 2001

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ASJC Scopus subject areas

  • Genetics

Cite this

Sklar, P., Schwab, S. G., Williams, N. M., Daly, M., Schaffner, S., Maier, W., Albus, M., Trixler, M., Eichhammer, P., Lerer, B., Hallmayer, J., Norton, N., Williams, H., Zammit, S., Cardno, A. G., Jones, S., McCarthy, G., Milanova, V., Kirov, G., ... Wildenauer, D. B. (2001). Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nature Genetics, 28(2), 126-128. https://doi.org/10.1038/88836