Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

Pamela Sklar; Sibylle G. Schwab; Nigel M. Williams; Mark Daly; Stephen Schaffner; Wolfgang Maier; Margot Albus; Matyas Trixler; Peter Eichhammer; Bernard Lerer; Joachim Hallmayer; Nadine Norton; Hywel Williams; Stan Zammit; Alastair G. Cardno; Sue Jones; Geraldine McCarthy; Vihra Milanova; George Kirov; Michael C. O'Donovan; Eric S. Lander; Michael J. Owen; Dieter B. Wildenauer

doi:10.1038/88836

Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

Pamela Sklar, Sibylle G. Schwab, Nigel M. Williams, Mark Daly, Stephen Schaffner, Wolfgang Maier, Margot Albus, Matyas Trixler, Peter Eichhammer, Bernard Lerer, Joachim Hallmayer, Nadine Norton, Hywel Williams, Stan Zammit, Alastair G. Cardno, Sue Jones, Geraldine McCarthy, Vihra Milanova, George Kirov, Michael C. O'DonovanEric S. Lander, Michael J. Owen, Dieter B. Wildenauer

Cancer Biology

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Abstract

A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

Original language	English (US)
Pages (from-to)	126-128
Number of pages	3
Journal	Nature Genetics
Volume	28
Issue number	2
DOIs	https://doi.org/10.1038/88836
State	Published - 2001

ASJC Scopus subject areas

Genetics

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Sklar, P., Schwab, S. G., Williams, N. M., Daly, M., Schaffner, S., Maier, W., Albus, M., Trixler, M., Eichhammer, P., Lerer, B., Hallmayer, J., Norton, N., Williams, H., Zammit, S., Cardno, A. G., Jones, S., McCarthy, G., Milanova, V., Kirov, G., ... Wildenauer, D. B. (2001). Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nature Genetics, 28(2), 126-128. https://doi.org/10.1038/88836

Sklar, P, Schwab, SG, Williams, NM, Daly, M, Schaffner, S, Maier, W, Albus, M, Trixler, M, Eichhammer, P, Lerer, B, Hallmayer, J, Norton, N, Williams, H, Zammit, S, Cardno, AG, Jones, S, McCarthy, G, Milanova, V, Kirov, G, O'Donovan, MC, Lander, ES, Owen, MJ & Wildenauer, DB 2001, 'Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls', Nature Genetics, vol. 28, no. 2, pp. 126-128. https://doi.org/10.1038/88836

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title = "Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls",

abstract = "A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.",

author = "Pamela Sklar and Schwab, {Sibylle G.} and Williams, {Nigel M.} and Mark Daly and Stephen Schaffner and Wolfgang Maier and Margot Albus and Matyas Trixler and Peter Eichhammer and Bernard Lerer and Joachim Hallmayer and Nadine Norton and Hywel Williams and Stan Zammit and Cardno, {Alastair G.} and Sue Jones and Geraldine McCarthy and Vihra Milanova and George Kirov and O'Donovan, {Michael C.} and Lander, {Eric S.} and Owen, {Michael J.} and Wildenauer, {Dieter B.}",

note = "Funding Information: We thank the patients and families for participation and Y.-M. Lim for technical assistance. This study was funded by a research grant from Bristol-Myers Squibb, Millennium Pharmaceuticals and Affymetrix (E.S.L.); the Medical Research Council (UK), the Wellcome Trust, and the Jansen Research Foundation (M.J.O., M.C.O. and G.K.); the German Israeli Foundation for Scientific Research (D.B.W. and B.L.); and Deutsche Forschungsgemeinschaft (SFB400) (W.M. and D.B.W.). Funding Information: We thank the families for their support and participation. We also thank Q. Feng and R. Kassollja for their technical assistance; F. Dewhirst, S. Boches and J. Galvin for assistance with sequencing; and G.D. Roodman for generously providing human osteoclast RNA. This study was supported in part by grants from Aventis and NIH (AR36819 and AR36820) to B.R.O.",

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AU - Schaffner, Stephen

AU - Maier, Wolfgang

AU - Albus, Margot

AU - Trixler, Matyas

AU - Eichhammer, Peter

AU - Lerer, Bernard

AU - Hallmayer, Joachim

AU - Norton, Nadine

AU - Williams, Hywel

AU - Zammit, Stan

AU - Cardno, Alastair G.

AU - Jones, Sue

AU - McCarthy, Geraldine

AU - Milanova, Vihra

AU - Kirov, George

AU - O'Donovan, Michael C.

AU - Lander, Eric S.

AU - Owen, Michael J.

AU - Wildenauer, Dieter B.

N1 - Funding Information: We thank the patients and families for participation and Y.-M. Lim for technical assistance. This study was funded by a research grant from Bristol-Myers Squibb, Millennium Pharmaceuticals and Affymetrix (E.S.L.); the Medical Research Council (UK), the Wellcome Trust, and the Jansen Research Foundation (M.J.O., M.C.O. and G.K.); the German Israeli Foundation for Scientific Research (D.B.W. and B.L.); and Deutsche Forschungsgemeinschaft (SFB400) (W.M. and D.B.W.). Funding Information: We thank the families for their support and participation. We also thank Q. Feng and R. Kassollja for their technical assistance; F. Dewhirst, S. Boches and J. Galvin for assistance with sequencing; and G.D. Roodman for generously providing human osteoclast RNA. This study was supported in part by grants from Aventis and NIH (AR36819 and AR36820) to B.R.O.

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Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

Abstract

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