Assignment of the Human Gene for the α1 Subunit of the Skeletal Muscle DHP-Sensitive Ca2+ Channel (CACNL1A3) to Chromosome 1q31-q32

Ronald G. Gregg, Fergus Couch, Kirk Hogan, Patricia A. Powers

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

A human clone corresponding to the gene encoding the α1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (CACNL1A3) has been isolated and partially sequenced. Oligonucleotides based on this sequence were used in a polymerase chain reaction to amplify specifically the human gene in human-rodent somatic cell hybrids, allowing the assignment of CACNL1A3 to chromosome 1. A polymorphic dinucleotide repeat also was identified in the human clone and using PCR was typed on a subset of the CEPH families. Multipoint linkage analysis places the CACNL1A3 gene between D1S52 and D1S70, on chromosome 1q31-q32.

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
JournalGenomics
Volume15
Issue number1
DOIs
StatePublished - Jan 1993

ASJC Scopus subject areas

  • Genetics

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