Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43

K. Neiswanger, D. R. Stanford, R. S. Sparkes, D. Nishimura, T. Mohandas, I. Klisak, C. Heinzmann, Eric D Wieben

Research output: Contribution to journalArticle

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Abstract

Small nuclear ribonucleoproteins (snRNPs), which are composed of various U RNAs and several proteins, are components of the mRNA splicing apparatus. The snRNP protein E is encoded by a multigene family which consists of a single expressed gene and several processed pseudogenes. We have used somatic cell hybridization, in situ hybridization, and linkage analysis to both physically and genetically map the expressed E protein gene to human chromosome 1q25-43, with the most probable location being band 1q32. In addition to the snRNP E protein gene, two other snRNP components-the U1 RNA true multigene family and a group of class I U1 pseudogenes-are located on human chromosome 1.

Original languageEnglish (US)
Pages (from-to)503-508
Number of pages6
JournalGenomics
Volume7
Issue number4
DOIs
StatePublished - 1990

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Small Nuclear Ribonucleoproteins
Human Chromosomes
Pseudogenes
Multigene Family
Genes
In Situ Hybridization
Proteins
Chromosomes, Human, Pair 1
RNA
Messenger RNA

ASJC Scopus subject areas

  • Genetics

Cite this

Neiswanger, K., Stanford, D. R., Sparkes, R. S., Nishimura, D., Mohandas, T., Klisak, I., ... Wieben, E. D. (1990). Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43. Genomics, 7(4), 503-508. https://doi.org/10.1016/0888-7543(90)90192-W

Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43. / Neiswanger, K.; Stanford, D. R.; Sparkes, R. S.; Nishimura, D.; Mohandas, T.; Klisak, I.; Heinzmann, C.; Wieben, Eric D.

In: Genomics, Vol. 7, No. 4, 1990, p. 503-508.

Research output: Contribution to journalArticle

Neiswanger, K, Stanford, DR, Sparkes, RS, Nishimura, D, Mohandas, T, Klisak, I, Heinzmann, C & Wieben, ED 1990, 'Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43', Genomics, vol. 7, no. 4, pp. 503-508. https://doi.org/10.1016/0888-7543(90)90192-W
Neiswanger K, Stanford DR, Sparkes RS, Nishimura D, Mohandas T, Klisak I et al. Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43. Genomics. 1990;7(4):503-508. https://doi.org/10.1016/0888-7543(90)90192-W
Neiswanger, K. ; Stanford, D. R. ; Sparkes, R. S. ; Nishimura, D. ; Mohandas, T. ; Klisak, I. ; Heinzmann, C. ; Wieben, Eric D. / Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43. In: Genomics. 1990 ; Vol. 7, No. 4. pp. 503-508.
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