Abstract
Small nuclear ribonucleoproteins (snRNPs), which are composed of various U RNAs and several proteins, are components of the mRNA splicing apparatus. The snRNP protein E is encoded by a multigene family which consists of a single expressed gene and several processed pseudogenes. We have used somatic cell hybridization, in situ hybridization, and linkage analysis to both physically and genetically map the expressed E protein gene to human chromosome 1q25-43, with the most probable location being band 1q32. In addition to the snRNP E protein gene, two other snRNP components-the U1 RNA true multigene family and a group of class I U1 pseudogenes-are located on human chromosome 1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 503-508 |
| Number of pages | 6 |
| Journal | Genomics |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1990 |
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- Genetics
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Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43. / Neiswanger, K.; Stanford, D. R.; Sparkes, R. S.; Nishimura, D.; Mohandas, T.; Klisak, I.; Heinzmann, C.; Wieben, Eric D.
In: Genomics, Vol. 7, No. 4, 1990, p. 503-508.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43
AU - Neiswanger, K.
AU - Stanford, D. R.
AU - Sparkes, R. S.
AU - Nishimura, D.
AU - Mohandas, T.
AU - Klisak, I.
AU - Heinzmann, C.
AU - Wieben, Eric D
PY - 1990
Y1 - 1990
N2 - Small nuclear ribonucleoproteins (snRNPs), which are composed of various U RNAs and several proteins, are components of the mRNA splicing apparatus. The snRNP protein E is encoded by a multigene family which consists of a single expressed gene and several processed pseudogenes. We have used somatic cell hybridization, in situ hybridization, and linkage analysis to both physically and genetically map the expressed E protein gene to human chromosome 1q25-43, with the most probable location being band 1q32. In addition to the snRNP E protein gene, two other snRNP components-the U1 RNA true multigene family and a group of class I U1 pseudogenes-are located on human chromosome 1.
AB - Small nuclear ribonucleoproteins (snRNPs), which are composed of various U RNAs and several proteins, are components of the mRNA splicing apparatus. The snRNP protein E is encoded by a multigene family which consists of a single expressed gene and several processed pseudogenes. We have used somatic cell hybridization, in situ hybridization, and linkage analysis to both physically and genetically map the expressed E protein gene to human chromosome 1q25-43, with the most probable location being band 1q32. In addition to the snRNP E protein gene, two other snRNP components-the U1 RNA true multigene family and a group of class I U1 pseudogenes-are located on human chromosome 1.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025157833&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(90)90192-W
DO - 10.1016/0888-7543(90)90192-W
M3 - Article
C2 - 2143747
AN - SCOPUS:0025157833
VL - 7
SP - 503
EP - 508
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 4
ER -