Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43

K. Neiswanger, D. R. Stanford, R. S. Sparkes, D. Nishimura, T. Mohandas, I. Klisak, C. Heinzmann, E. D. Wieben

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Small nuclear ribonucleoproteins (snRNPs), which are composed of various U RNAs and several proteins, are components of the mRNA splicing apparatus. The snRNP protein E is encoded by a multigene family which consists of a single expressed gene and several processed pseudogenes. We have used somatic cell hybridization, in situ hybridization, and linkage analysis to both physically and genetically map the expressed E protein gene to human chromosome 1q25-43, with the most probable location being band 1q32. In addition to the snRNP E protein gene, two other snRNP components-the U1 RNA true multigene family and a group of class I U1 pseudogenes-are located on human chromosome 1.

Original languageEnglish (US)
Pages (from-to)503-508
Number of pages6
JournalGenomics
Volume7
Issue number4
DOIs
StatePublished - Aug 1990

ASJC Scopus subject areas

  • Genetics

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    Neiswanger, K., Stanford, D. R., Sparkes, R. S., Nishimura, D., Mohandas, T., Klisak, I., Heinzmann, C., & Wieben, E. D. (1990). Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43. Genomics, 7(4), 503-508. https://doi.org/10.1016/0888-7543(90)90192-W