Assignment of a novel bifurcated SET domain gene, SETDB1, to human chromosome band 1q21 by in situ hybridization and radiation hybrids

P. J. Harte, W. Wu, M. M. Carrasquillo, Greg Matera

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

We have identified a human gene encoding an unusual bifurcated SET domain protein containing a large 'insertion' between the most highly conserved parts of the SET domain. The existence of an evolutionarily related C. elegans gene encoding a similarly bifurcated SET domain suggests that SET domains may generally be composed of two functionally distinct subdomains. We mapped this gene, called SETDB1, to human chromosome 1q21. This region is targeted by a large number of recurrent translocations, suggesting that like the SET domain protein MLL, mutant forms of SETDB1 may be associated with human neoplasias.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalCytogenetics and Cell Genetics
Volume84
Issue number1-2
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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