Assessment of Thoracic Blood Volume by Computerized Tomography in Patients With Heart Failure and Periodic Breathing

Caitlin C. Jorgenson, Steven C. Chase, Lyle J. Olson, Bruce D. Johnson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Periodic breathing (PB) is often observed in patients with HF at rest, with sleep and during exercise. However, mechanisms underlying abnormal ventilatory control are not entirely established. Methods: Eleven subjects with HF (10 males, age = 69 ± 12 y) and 12 age-matched control subjects (8 males, age = 65 ± 9 y) participated in the study. PB was defined as a peak in the 0.003–0.04 Hz frequency range of the flow signal during 6 minutes of awake resting breathing. Thoracic blood volumes (V t , thorax; V h , heart; V p , pulmonary), mean transit times (MTTs), and extravascular lung water (EVLW) were quantified using computerized tomography. Results: PB was observed in 7 subjects with HF and was associated with worse functional status. The HF PB-present group had thoracic blood volumes nearly double those of control and HF PB-absent subjects (volumes reported as mL/m 2 body surface area, P values vs control: control = 813 ± 246, HF PB-absent = 822 ± 161 P =.981, HF PB-present = 1579 ± 548 P =.002). PB was associated with longer pulmonary MTT (control = 6.7 ± 1.2 s, HF PB-absent = 6.0 ± 0.8 s, HF PB-present = 8.4 ± 1.6 s; P =.033, HF PB-present vs HF PB-absent). EVLW was not elevated in the PB group. Conclusions: Subjects with HF and PB at rest have greater centralization of blood volume.

Original languageEnglish (US)
Pages (from-to)479-483
Number of pages5
JournalJournal of Cardiac Failure
Volume24
Issue number7
DOIs
StatePublished - Jul 2018

Keywords

  • Thoracic fluid volumes
  • extravascular lung water
  • mean transit time

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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