Assessment of stiffness changes in the ex vivo porcine aortic wall using magnetic resonance elastography

Lei Xu, Jun Chen, Meng Yin, Kevin J. Glaser, Qingshan Chen, David A. Woodrum, Richard L. Ehman

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Magnetic resonance elastography (MRE) is a noninvasive phase-contrast technique for estimating the mechanical properties of tissues by imaging propagating mechanical waves within the tissue. In this study, we hypothesize that changes in arterial wall stiffness, experimentally induced by formalin fixation, can be measured using MRE in ex vivo porcine aortas. In agreement with our hypothesis, the significant stiffness increase after sample fixation was clearly demonstrated by MRE and confirmed by mechanical testing. The results indicate that MRE can be used to examine the stiffness changes of the aorta. This study has provided evidence of the effectiveness of using MRE to directly assess the stiffness change in aortic wall. The results offer motivation to pursue MRE as a noninvasive method for the evaluation of arterial wall mechanical properties.

Original languageEnglish (US)
Pages (from-to)122-127
Number of pages6
JournalMagnetic Resonance Imaging
Volume30
Issue number1
DOIs
StatePublished - Jan 1 2012

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Keywords

  • Aorta
  • Elastography
  • MRI
  • Stiffness

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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