Assessment of proton beam ablation in myocardial infarct tissue using delayed contrast-enhanced magnetic resonance imaging

M. E. Rettmann, S. Hohmann, A. J. Deisher, H. Konishi, J. J. Kruse, L. K. Newman, K. D. Parker, M. G. Herman, D. L. Packer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

External beam therapy has recently been proposed for treatment of ventricular tachycardia (VT). One of the goals of VT ablation is to eliminate myocardial channels by homogenizing infarct scar, thereby inhibiting reentry and eliminating VT. It has been previously shown that proton beam therapy can create lesions in healthy myocardial tissue, thereby suggesting a potential for treatment of VT. To date; however, the effects of proton beam energy in infarcted myocardial tissue is unknown. In the current work, we track proton beam dose maps in a series of delayed contrast-enhanced magnetic resonance imaging swine datasets across 16 weeks to assess the effects of proton beam ablation on infarcted myocardial tissue.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2020
Subtitle of host publicationImage-Guided Procedures, Robotic Interventions, and Modeling
EditorsBaowei Fei, Cristian A. Linte
PublisherSPIE
ISBN (Electronic)9781510633971
DOIs
StatePublished - Jan 1 2020
EventMedical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling - Houston, United States
Duration: Feb 16 2020Feb 19 2020

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11315
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceMedical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling
CountryUnited States
CityHouston
Period2/16/202/19/20

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Rettmann, M. E., Hohmann, S., Deisher, A. J., Konishi, H., Kruse, J. J., Newman, L. K., Parker, K. D., Herman, M. G., & Packer, D. L. (2020). Assessment of proton beam ablation in myocardial infarct tissue using delayed contrast-enhanced magnetic resonance imaging. In B. Fei, & C. A. Linte (Eds.), Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling [1131511] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11315). SPIE. https://doi.org/10.1117/12.2550659