Assessment of patient and caregiver experiences of dementia-related symptoms: Development of the multidimensional assessment of neurodegenerative symptoms questionnaire

Dona E.C. Locke, Kara B. Dassel, Geri Hall, Leslie C. Baxter, Bryan K. Woodruff, Charlene Hoffman Snyder, Bruce L. Miller, Richard J. Caselli

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background: To provide preliminary validation data on a self- or informant-report multidimensional questionnaire of symptoms associated with neurodegenerative disorders. Methods: Participants from 2 trials (n = 125), the Arizona APOE Cohort and the Arizona Alzheimer's Disease Center, completed the Multidimensional Assessment of Neurodegenerative Symptoms questionnaire (MANS) and other related measures. Results: Measures of central tendency are provided for the sample as a whole and by cognitive status. Internal consistency of the MANS is excellent (α = 0.98). Factor analysis suggests 4 factors. Correlational analyses support the construct validity of the MANS with moderate to high (r = 0.54-0.87) correlations between the MANS and measures of mood, cognition and daily functioning. Conclusion: Results provide initial support for the MANS as a brief measure that is a reliable and valid indicator of cognitive, personality, functional and motor symptoms potentially related to neurodegenerative etiologies. Further research with the MANS is warranted.

Original languageEnglish (US)
Pages (from-to)260-272
Number of pages13
JournalDementia and geriatric cognitive disorders
Volume27
Issue number3
DOIs
StatePublished - Mar 2009

Keywords

  • Multidimensional questionnaire
  • Neurodegenerative disorders
  • Validation

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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