Assessment of patient and caregiver experiences of dementia-related symptoms: Development of the multidimensional assessment of neurodegenerative symptoms questionnaire

Dona E.C. Locke; Kara B. Dassel; Geri Hall; Leslie C. Baxter; Bryan K. Woodruff; Charlene Hoffman Snyder; Bruce L. Miller; Richard J. Caselli

doi:10.1159/000203890

Assessment of patient and caregiver experiences of dementia-related symptoms: Development of the multidimensional assessment of neurodegenerative symptoms questionnaire

Dona E.C. Locke, Kara B. Dassel, Geri Hall, Leslie C. Baxter, Bryan K. Woodruff, Charlene Hoffman Snyder, Bruce L. Miller, Richard J. Caselli

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: To provide preliminary validation data on a self- or informant-report multidimensional questionnaire of symptoms associated with neurodegenerative disorders. Methods: Participants from 2 trials (n = 125), the Arizona APOE Cohort and the Arizona Alzheimer's Disease Center, completed the Multidimensional Assessment of Neurodegenerative Symptoms questionnaire (MANS) and other related measures. Results: Measures of central tendency are provided for the sample as a whole and by cognitive status. Internal consistency of the MANS is excellent (α = 0.98). Factor analysis suggests 4 factors. Correlational analyses support the construct validity of the MANS with moderate to high (r = 0.54-0.87) correlations between the MANS and measures of mood, cognition and daily functioning. Conclusion: Results provide initial support for the MANS as a brief measure that is a reliable and valid indicator of cognitive, personality, functional and motor symptoms potentially related to neurodegenerative etiologies. Further research with the MANS is warranted.

Original language	English (US)
Pages (from-to)	260-272
Number of pages	13
Journal	Dementia and geriatric cognitive disorders
Volume	27
Issue number	3
DOIs	https://doi.org/10.1159/000203890
State	Published - Mar 2009

Keywords

Multidimensional questionnaire
Neurodegenerative disorders
Validation

ASJC Scopus subject areas

Geriatrics and Gerontology
Cognitive Neuroscience
Psychiatry and Mental health

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10.1159/000203890

Cite this

Locke, D. E. C., Dassel, K. B., Hall, G., Baxter, L. C., Woodruff, B. K., Hoffman Snyder, C., Miller, B. L., & Caselli, R. J. (2009). Assessment of patient and caregiver experiences of dementia-related symptoms: Development of the multidimensional assessment of neurodegenerative symptoms questionnaire. Dementia and geriatric cognitive disorders, 27(3), 260-272. https://doi.org/10.1159/000203890

Assessment of patient and caregiver experiences of dementia-related symptoms: Development of the multidimensional assessment of neurodegenerative symptoms questionnaire. / Locke, Dona E.C.; Dassel, Kara B.; Hall, Geri et al.
In: Dementia and geriatric cognitive disorders, Vol. 27, No. 3, 03.2009, p. 260-272.

Research output: Contribution to journal › Article › peer-review

Locke, DEC, Dassel, KB, Hall, G, Baxter, LC, Woodruff, BK, Hoffman Snyder, C, Miller, BL & Caselli, RJ 2009, 'Assessment of patient and caregiver experiences of dementia-related symptoms: Development of the multidimensional assessment of neurodegenerative symptoms questionnaire', Dementia and geriatric cognitive disorders, vol. 27, no. 3, pp. 260-272. https://doi.org/10.1159/000203890

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abstract = "Background: To provide preliminary validation data on a self- or informant-report multidimensional questionnaire of symptoms associated with neurodegenerative disorders. Methods: Participants from 2 trials (n = 125), the Arizona APOE Cohort and the Arizona Alzheimer's Disease Center, completed the Multidimensional Assessment of Neurodegenerative Symptoms questionnaire (MANS) and other related measures. Results: Measures of central tendency are provided for the sample as a whole and by cognitive status. Internal consistency of the MANS is excellent (α = 0.98). Factor analysis suggests 4 factors. Correlational analyses support the construct validity of the MANS with moderate to high (r = 0.54-0.87) correlations between the MANS and measures of mood, cognition and daily functioning. Conclusion: Results provide initial support for the MANS as a brief measure that is a reliable and valid indicator of cognitive, personality, functional and motor symptoms potentially related to neurodegenerative etiologies. Further research with the MANS is warranted.",

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Assessment of patient and caregiver experiences of dementia-related symptoms: Development of the multidimensional assessment of neurodegenerative symptoms questionnaire

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Keywords

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