Assessment of myocardial perfusion during adenosine stress using real time three-dimensional and two-dimensional myocardial contrast echocardiography: Comparison with single-photon emission computed tomography

Sahar S. Abdelmoneim, Mathieu Bernier, Abhijeet Dhoble, Stuart Moir, Mary E. Hagen, Sue Ann C. Ness, Samir S. Abdel-Kader, Patricia A. Pellikka, Sharon L. Mulvagh

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Objectives: To evaluate diagnostic accuracy of adenosine two-dimensional and three-dimensional myocardial contrast echocardiography (2D- and 3D-MCE) compared with single-photon emission computed tomography (SPECT) for assessing myocardial perfusion. Methods: From January through August 2007, patients with known or suspected CAD who were referred for SPECT underwent simultaneous adenosine 2D-MCE and 3D-MCE (live and full volume FV). Perfusion and wall motion in 17 segments in the left anterior descending, left circumflex, and right coronary artery territories were analyzed. Results: We studied 30 patients: mean (SD) age, 72.6 (8.2) years; 19 (63%) men. Perfusion by SPECT was abnormal in 13 patients (43%). When comparing MCE with SPECT, sensitivity was comparable for 2D-MCE, 92%; live 3D-MCE, 91%; and FV 3D-MCE, 90%. Specificity was comparable for 2D-MCE, 75%; live 3D-MCE, 69%; and FV 3D-MCE, 79%. Agreement between live 3D-MCE and 2D-MCE was 92% (κSE, 0.83 0.17) and between FV 3D-MCE and 2D-MCE, 88% (κSE, 0.76 0.13). For eight patients in whom SPECT showed reversible defects, live 3D-MCE correctly identified defects in seven (88%), whereas FV 3D-MCE correctly identified them in five (63%) (P = 0.57). Conclusion: Myocardial perfusion assessment is feasible by 3D-MCE with the advantage of rapid, facile acquisition and offline image manipulation. (Echocardiography 2010;27:421-429)

Original languageEnglish (US)
Pages (from-to)421-429
Number of pages9
JournalEchocardiography
Volume27
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • 3-dimensional echocardiography
  • Contrast echocardiography
  • Coronary artery disease
  • Single-photon emission computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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