Assessment of interaction between carcinogens in long-term factorially designed animal experiments.

S. G. Machado, Kent R Bailey

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Two substances interact if the combined action results in an effect which is greater than, or less than, that of the sum of the effects produced separately by the substances. Finney (1971, Probit Analysis, 3rd ed. Cambridge: Cambridge University Press) proposed a probabilistic model for simple independent action of two substances for the case of dichotomous outcomes. Using Finney's underlying model, we examine tests for interaction between carcinogens or toxic substances for data from long-term 2 x 2 and 2 x 2 x 2 factorially designed animal experiments. The outcome of interest is the occurrence or not of a certain event (for example, the appearance of a tumor) and the time at which the event occurred. The proposed tests are based on the proportional hazards model. We discuss some simple methods for checking the appropriateness of the proportional hazards assumption. Applications of the tests are made to data from a 2 x 2 and a 2 x 2 x 2 experiment.

Original languageEnglish (US)
Pages (from-to)539-545
Number of pages7
JournalBiometrics
Volume41
Issue number2
StatePublished - Jun 1985
Externally publishedYes

Fingerprint

Carcinogens
animal experimentation
Poisons
Statistical Models
carcinogens
Proportional Hazards Models
Animals
Hazards
Interaction
Experiment
Tumors
Probit
probit analysis
probabilistic models
Neoplasms
Proportional Hazards
Proportional Hazards Model
Experiments
testing
toxic substances

ASJC Scopus subject areas

  • Statistics and Probability
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Assessment of interaction between carcinogens in long-term factorially designed animal experiments. / Machado, S. G.; Bailey, Kent R.

In: Biometrics, Vol. 41, No. 2, 06.1985, p. 539-545.

Research output: Contribution to journalArticle

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