Assessment of hindlimb gait as a powerful indicator of axonal loss in a murine model of progressive CNS demyelination

Dorian B. McGavern; Laurie Zoecklein; Sith Sathornsumetee; Moses Rodriguez

doi:10.1016/S0006-8993(00)02710-4

Assessment of hindlimb gait as a powerful indicator of axonal loss in a murine model of progressive CNS demyelination

Dorian B. McGavern, Laurie Zoecklein, Sith Sathornsumetee, Moses Rodriguez

Neurology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Identifying the role of axonal injury in the development of permanent, irreversible neurologic disability is important to the study of central nervous system (CNS) demyelinating diseases. Our understanding of neurologic dysfunction in demyelinating diseases and the ability to assess therapeutic interventions depends on the development of objective functional assays that can non-invasively measure axonal loss. In this study, we demonstrate in a murine model of progressive CNS demyelination that assessment of the hindlimb width of stride provides a powerful indicator axonal loss and can dissociate between deficits induced by demyelination versus axonal loss. (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	396-400
Number of pages	5
Journal	Brain Research
Volume	877
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(00)02710-4
State	Published - Sep 22 2000

Keywords

Footprint
Motor function
Multiple sclerosis
Neurodegeneration
Oligodendrocyte
Theiler's virus

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(00)02710-4

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title = "Assessment of hindlimb gait as a powerful indicator of axonal loss in a murine model of progressive CNS demyelination",

abstract = "Identifying the role of axonal injury in the development of permanent, irreversible neurologic disability is important to the study of central nervous system (CNS) demyelinating diseases. Our understanding of neurologic dysfunction in demyelinating diseases and the ability to assess therapeutic interventions depends on the development of objective functional assays that can non-invasively measure axonal loss. In this study, we demonstrate in a murine model of progressive CNS demyelination that assessment of the hindlimb width of stride provides a powerful indicator axonal loss and can dissociate between deficits induced by demyelination versus axonal loss. (C) 2000 Elsevier Science B.V.",

keywords = "Footprint, Motor function, Multiple sclerosis, Neurodegeneration, Oligodendrocyte, Theiler's virus",

author = "McGavern, {Dorian B.} and Laurie Zoecklein and Sith Sathornsumetee and Moses Rodriguez",

note = "Funding Information: This work was supported by the National Institutes of Health grants: RO1 NS24180, RO1 NS32129, and the generous contributions of Mr. and Mrs. Eugene Applebaum and Ms. Kathryn Peterson. D.B.M. is supported by a predoctoral NRSA from the National Institute of Mental Health (Grant#1F31ME12120). S.S. is supported by the Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand.",

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AU - McGavern, Dorian B.

AU - Zoecklein, Laurie

AU - Sathornsumetee, Sith

AU - Rodriguez, Moses

N1 - Funding Information: This work was supported by the National Institutes of Health grants: RO1 NS24180, RO1 NS32129, and the generous contributions of Mr. and Mrs. Eugene Applebaum and Ms. Kathryn Peterson. D.B.M. is supported by a predoctoral NRSA from the National Institute of Mental Health (Grant#1F31ME12120). S.S. is supported by the Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand.

PY - 2000/9/22

Y1 - 2000/9/22

N2 - Identifying the role of axonal injury in the development of permanent, irreversible neurologic disability is important to the study of central nervous system (CNS) demyelinating diseases. Our understanding of neurologic dysfunction in demyelinating diseases and the ability to assess therapeutic interventions depends on the development of objective functional assays that can non-invasively measure axonal loss. In this study, we demonstrate in a murine model of progressive CNS demyelination that assessment of the hindlimb width of stride provides a powerful indicator axonal loss and can dissociate between deficits induced by demyelination versus axonal loss. (C) 2000 Elsevier Science B.V.

AB - Identifying the role of axonal injury in the development of permanent, irreversible neurologic disability is important to the study of central nervous system (CNS) demyelinating diseases. Our understanding of neurologic dysfunction in demyelinating diseases and the ability to assess therapeutic interventions depends on the development of objective functional assays that can non-invasively measure axonal loss. In this study, we demonstrate in a murine model of progressive CNS demyelination that assessment of the hindlimb width of stride provides a powerful indicator axonal loss and can dissociate between deficits induced by demyelination versus axonal loss. (C) 2000 Elsevier Science B.V.

KW - Footprint

KW - Motor function

KW - Multiple sclerosis

KW - Neurodegeneration

KW - Oligodendrocyte

KW - Theiler's virus

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Assessment of hindlimb gait as a powerful indicator of axonal loss in a murine model of progressive CNS demyelination

Abstract

Keywords

ASJC Scopus subject areas

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