Assessment of hindlimb gait as a powerful indicator of axonal loss in a murine model of progressive CNS demyelination

Dorian B. McGavern, Laurie Zoecklein, Sith Sathornsumetee, Moses Rodriguez

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Identifying the role of axonal injury in the development of permanent, irreversible neurologic disability is important to the study of central nervous system (CNS) demyelinating diseases. Our understanding of neurologic dysfunction in demyelinating diseases and the ability to assess therapeutic interventions depends on the development of objective functional assays that can non-invasively measure axonal loss. In this study, we demonstrate in a murine model of progressive CNS demyelination that assessment of the hindlimb width of stride provides a powerful indicator axonal loss and can dissociate between deficits induced by demyelination versus axonal loss. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)396-400
Number of pages5
JournalBrain Research
Volume877
Issue number2
DOIs
StatePublished - Sep 22 2000

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Keywords

  • Footprint
  • Motor function
  • Multiple sclerosis
  • Neurodegeneration
  • Oligodendrocyte
  • Theiler's virus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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