Assessment of Abnormal Liver Injury Tests

Mashal Jatoi Batheja, Hugo E. Vargas

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Evidence of hepatic injury on routine biochemical evaluation should prompt a rapid decision-making process in the clinician. Elevations of hepatocellular injury tests (AST, ALT) should be evaluated with an eye to the relative magnitude, pace of elevation and relative increase over other markers. This way, appropriate resources can be devoted to rapid evaluation. Increases in cholestatic injury tests (Alkaline phosphatase liver fraction, γ-glutamyl transpeptidase and bilirubin) should prompt assessment of biliary tree anatomy and consideration of autoimmune, metabolic or toxic injury of the liver. Finally, the liver's ability to synthesize factors such as albumin and factor V is a very quick gauge of the extent of the liver injury.

Original languageEnglish (US)
Title of host publicationPractical Gastroenterology and Hepatology
Subtitle of host publicationLiver and Biliary Disease
PublisherWiley-Blackwell
Pages32-37
Number of pages6
ISBN (Print)9781405182751
DOIs
StatePublished - Aug 31 2010

Keywords

  • Alanine aminotransferase
  • Alkaline phosphatase
  • Aspartate transaminase
  • Bilirubin
  • Prothrombin time
  • γ-glutamyl transpeptidase

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Batheja, M. J., & Vargas, H. E. (2010). Assessment of Abnormal Liver Injury Tests. In Practical Gastroenterology and Hepatology: Liver and Biliary Disease (pp. 32-37). Wiley-Blackwell. https://doi.org/10.1002/9781444325249.ch4