Assessing vasculitis in giant cell arteritis by ultrasound

Results of OMERACT patient-based reliability exercises

Valentin S. Schäfer, Stavros Chrysidis, Christian Dejaco, Christina Duftner, Annamaria Iagnocco, George A. Bruyn, Greta Carrara, Maria Antonietta D'Agostino, Eugenio De Miguel, Andreas P. Diamantopoulos, Ulrich Fredberg, Wolfgang Hartung, Alojzija Hocevar, Aaron Juche, Tanaz A. Kermani, Matthew Koster, Tove Lorenzen, Pierluigi Macchioni, Marcin Milchert, Uffe Møller Døhn & 8 others Chetan Mukhtyar, Cristina Ponte, Sofia Ramiro, Carlo A. Scirè, Lene Terslev, Kenneth J Warrington, Bhaskar Dasgupta, Wolfgang A. Schmidt

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To test the reliability of Outcome Measures in Rheumatology Clinical Trials (OMERACT) consensus-based ultrasound definitions for normal and vasculitic temporal and axillary arteries in patients with giant cell arteritis (GCA) and in controls. Methods: A preliminary 1-day meeting and a full 3-day meeting fulfilling OMERACT Ultrasound Group guidelines were held. Temporal and axillary arteries were examined at 2 timepoints by 12 sonographers on 4 patients with GCA and 2 controls. The aim was to test inter- and intrareader reliability for normal findings, halo sign, and compression sign. In both meetings, patients had established GCA. Pathology was more recent in the full meeting, which was preceded by 6 h of training. Scanning time was 15-20 min instead of 10-13 min. Results: In the preliminary exercise, interreader reliabilities were fair to moderate for the overall diagnosis of GCA (Light k 0.29-0.51), and poor to fair for identifying vasculitis in the respective anatomical segments (Light k 0.02-0.46). Intrareader reliabilities were moderate (Cohen k 0.32-0.64). In the main exercise, interreader reliability was good to excellent (Light k 0.76-0.86) for the overall diagnosis of GCA, and moderate to good (Light k 0.46-0.71) for identifying vasculitis in the respective anatomical segments. Intrareader reliability was excellent for diagnosis of GCA (Cohen k 0.91) and good (Cohen k 0.71-0.80) for the anatomical segments. Conclusion: OMERACT-derived definitions of halo and compression signs of temporal and axillary arteries are reliable in recent-onset GCA if experienced sonographers (> 300 examinations) have 15-20 min for a standardized examination with prior training and apply > 15 MHz probes.

Original languageEnglish (US)
Pages (from-to)1289-1295
Number of pages7
JournalJournal of Rheumatology
Volume45
Issue number9
DOIs
StatePublished - Sep 1 2018

Fingerprint

Giant Cell Arteritis
Rheumatology
Vasculitis
Outcome Assessment (Health Care)
Clinical Trials
Exercise
Axillary Artery
Temporal Arteries
Light
Guidelines
Pathology

Keywords

  • Diagnosis
  • Giant Cell Arteritis
  • Ultrasound Reliability
  • Vasculitis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Schäfer, V. S., Chrysidis, S., Dejaco, C., Duftner, C., Iagnocco, A., Bruyn, G. A., ... Schmidt, W. A. (2018). Assessing vasculitis in giant cell arteritis by ultrasound: Results of OMERACT patient-based reliability exercises. Journal of Rheumatology, 45(9), 1289-1295. https://doi.org/10.3899/jrheum.171428

Assessing vasculitis in giant cell arteritis by ultrasound : Results of OMERACT patient-based reliability exercises. / Schäfer, Valentin S.; Chrysidis, Stavros; Dejaco, Christian; Duftner, Christina; Iagnocco, Annamaria; Bruyn, George A.; Carrara, Greta; D'Agostino, Maria Antonietta; De Miguel, Eugenio; Diamantopoulos, Andreas P.; Fredberg, Ulrich; Hartung, Wolfgang; Hocevar, Alojzija; Juche, Aaron; Kermani, Tanaz A.; Koster, Matthew; Lorenzen, Tove; Macchioni, Pierluigi; Milchert, Marcin; Døhn, Uffe Møller; Mukhtyar, Chetan; Ponte, Cristina; Ramiro, Sofia; Scirè, Carlo A.; Terslev, Lene; Warrington, Kenneth J; Dasgupta, Bhaskar; Schmidt, Wolfgang A.

In: Journal of Rheumatology, Vol. 45, No. 9, 01.09.2018, p. 1289-1295.

Research output: Contribution to journalArticle

Schäfer, VS, Chrysidis, S, Dejaco, C, Duftner, C, Iagnocco, A, Bruyn, GA, Carrara, G, D'Agostino, MA, De Miguel, E, Diamantopoulos, AP, Fredberg, U, Hartung, W, Hocevar, A, Juche, A, Kermani, TA, Koster, M, Lorenzen, T, Macchioni, P, Milchert, M, Døhn, UM, Mukhtyar, C, Ponte, C, Ramiro, S, Scirè, CA, Terslev, L, Warrington, KJ, Dasgupta, B & Schmidt, WA 2018, 'Assessing vasculitis in giant cell arteritis by ultrasound: Results of OMERACT patient-based reliability exercises', Journal of Rheumatology, vol. 45, no. 9, pp. 1289-1295. https://doi.org/10.3899/jrheum.171428
Schäfer, Valentin S. ; Chrysidis, Stavros ; Dejaco, Christian ; Duftner, Christina ; Iagnocco, Annamaria ; Bruyn, George A. ; Carrara, Greta ; D'Agostino, Maria Antonietta ; De Miguel, Eugenio ; Diamantopoulos, Andreas P. ; Fredberg, Ulrich ; Hartung, Wolfgang ; Hocevar, Alojzija ; Juche, Aaron ; Kermani, Tanaz A. ; Koster, Matthew ; Lorenzen, Tove ; Macchioni, Pierluigi ; Milchert, Marcin ; Døhn, Uffe Møller ; Mukhtyar, Chetan ; Ponte, Cristina ; Ramiro, Sofia ; Scirè, Carlo A. ; Terslev, Lene ; Warrington, Kenneth J ; Dasgupta, Bhaskar ; Schmidt, Wolfgang A. / Assessing vasculitis in giant cell arteritis by ultrasound : Results of OMERACT patient-based reliability exercises. In: Journal of Rheumatology. 2018 ; Vol. 45, No. 9. pp. 1289-1295.
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T1 - Assessing vasculitis in giant cell arteritis by ultrasound

T2 - Results of OMERACT patient-based reliability exercises

AU - Schäfer, Valentin S.

AU - Chrysidis, Stavros

AU - Dejaco, Christian

AU - Duftner, Christina

AU - Iagnocco, Annamaria

AU - Bruyn, George A.

AU - Carrara, Greta

AU - D'Agostino, Maria Antonietta

AU - De Miguel, Eugenio

AU - Diamantopoulos, Andreas P.

AU - Fredberg, Ulrich

AU - Hartung, Wolfgang

AU - Hocevar, Alojzija

AU - Juche, Aaron

AU - Kermani, Tanaz A.

AU - Koster, Matthew

AU - Lorenzen, Tove

AU - Macchioni, Pierluigi

AU - Milchert, Marcin

AU - Døhn, Uffe Møller

AU - Mukhtyar, Chetan

AU - Ponte, Cristina

AU - Ramiro, Sofia

AU - Scirè, Carlo A.

AU - Terslev, Lene

AU - Warrington, Kenneth J

AU - Dasgupta, Bhaskar

AU - Schmidt, Wolfgang A.

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N2 - Objective: To test the reliability of Outcome Measures in Rheumatology Clinical Trials (OMERACT) consensus-based ultrasound definitions for normal and vasculitic temporal and axillary arteries in patients with giant cell arteritis (GCA) and in controls. Methods: A preliminary 1-day meeting and a full 3-day meeting fulfilling OMERACT Ultrasound Group guidelines were held. Temporal and axillary arteries were examined at 2 timepoints by 12 sonographers on 4 patients with GCA and 2 controls. The aim was to test inter- and intrareader reliability for normal findings, halo sign, and compression sign. In both meetings, patients had established GCA. Pathology was more recent in the full meeting, which was preceded by 6 h of training. Scanning time was 15-20 min instead of 10-13 min. Results: In the preliminary exercise, interreader reliabilities were fair to moderate for the overall diagnosis of GCA (Light k 0.29-0.51), and poor to fair for identifying vasculitis in the respective anatomical segments (Light k 0.02-0.46). Intrareader reliabilities were moderate (Cohen k 0.32-0.64). In the main exercise, interreader reliability was good to excellent (Light k 0.76-0.86) for the overall diagnosis of GCA, and moderate to good (Light k 0.46-0.71) for identifying vasculitis in the respective anatomical segments. Intrareader reliability was excellent for diagnosis of GCA (Cohen k 0.91) and good (Cohen k 0.71-0.80) for the anatomical segments. Conclusion: OMERACT-derived definitions of halo and compression signs of temporal and axillary arteries are reliable in recent-onset GCA if experienced sonographers (> 300 examinations) have 15-20 min for a standardized examination with prior training and apply > 15 MHz probes.

AB - Objective: To test the reliability of Outcome Measures in Rheumatology Clinical Trials (OMERACT) consensus-based ultrasound definitions for normal and vasculitic temporal and axillary arteries in patients with giant cell arteritis (GCA) and in controls. Methods: A preliminary 1-day meeting and a full 3-day meeting fulfilling OMERACT Ultrasound Group guidelines were held. Temporal and axillary arteries were examined at 2 timepoints by 12 sonographers on 4 patients with GCA and 2 controls. The aim was to test inter- and intrareader reliability for normal findings, halo sign, and compression sign. In both meetings, patients had established GCA. Pathology was more recent in the full meeting, which was preceded by 6 h of training. Scanning time was 15-20 min instead of 10-13 min. Results: In the preliminary exercise, interreader reliabilities were fair to moderate for the overall diagnosis of GCA (Light k 0.29-0.51), and poor to fair for identifying vasculitis in the respective anatomical segments (Light k 0.02-0.46). Intrareader reliabilities were moderate (Cohen k 0.32-0.64). In the main exercise, interreader reliability was good to excellent (Light k 0.76-0.86) for the overall diagnosis of GCA, and moderate to good (Light k 0.46-0.71) for identifying vasculitis in the respective anatomical segments. Intrareader reliability was excellent for diagnosis of GCA (Cohen k 0.91) and good (Cohen k 0.71-0.80) for the anatomical segments. Conclusion: OMERACT-derived definitions of halo and compression signs of temporal and axillary arteries are reliable in recent-onset GCA if experienced sonographers (> 300 examinations) have 15-20 min for a standardized examination with prior training and apply > 15 MHz probes.

KW - Diagnosis

KW - Giant Cell Arteritis

KW - Ultrasound Reliability

KW - Vasculitis

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