Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research

Shona Hendry, Roberto Salgado, Thomas Gevaert, Prudence A. Russell, Tom John, Bibhusal Thapa, Michael Christie, Koen Van De Vijver, M. V. Estrada, Paula I. Gonzalez-Ericsson, Melinda Sanders, Benjamin Solomon, Cinzia Solinas, Gert G.G.M. Van Den Eynden, Yves Allory, Matthias Preusser, Johannes Hainfellner, Giancarlo Pruneri, Andrea Vingiani, Sandra DemariaFraser Symmans, Paolo Nuciforo, Laura Comerma, E Aubrey Thompson, Sunil Lakhani, Seong Rim Kim, Stuart Schnitt, Cecile Colpaert, Christos Sotiriou, Stefan J. Scherer, Michail Ignatiadis, Sunil Badve, Robert H. Pierce, Giuseppe Viale, Nicolas Sirtaine, Frederique Penault-Llorca, Tomohagu Sugie, Susan Fineberg, Soonmyung Paik, Ashok Srinivasan, Andrea Richardson, Yihong Wang, Ewa Chmielik, Jane Brock, Douglas B. Johnson, Justin Balko, Stephan Wienert, Veerle Bossuyt, Stefan Michiels, Nils Ternes, Nicole Burchardi, Stephen J. Luen, Peter Savas, Frederick Klauschen, Peter H. Watson, Brad H. Nelson, Carmen Criscitiello, Sandra O'Toole, Denis Larsimont, Roland De Wind, Giuseppe Curigliano, Fabrice André, Magali Lacroix-Triki, Mark Van De Vijver, Federico Rojo, Giuseppe Floris, Shahinaz Bedri, Joseph Sparano, David Rimm, Torsten Nielsen, Zuzana Kos, Stephen Hewitt, Baljit Singh, Gelareh Farshid, Sibylle Loibl, Kimberly H. Allison, Nadine Tung, Sylvia Adams, Karen Willard-Gallo, Hugo M. Horlings, Leena Gandhi, Andre Moreira, Fred Hirsch, Maria V. Dieci, Maria Urbanowicz, Iva Brcic, Konstanty Korski, Fabien Gaire, Hartmut Koeppen, Amy Lo, Jennifer Giltnane, Marlon C. Rebelatto, Keith E. Steele, Jiping Zha, Kenneth Emancipator, Jonathan W. Juco, Carsten Denkert, Jorge Reis-Filho, Sherene Loi, Stephen B. Fox

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy.

Original languageEnglish (US)
Pages (from-to)235-251
Number of pages17
JournalAdvances in Anatomic Pathology
Volume24
Issue number5
DOIs
StatePublished - Jan 1 2017

Fingerprint

Tumor-Infiltrating Lymphocytes
Carcinoma, Intraductal, Noninfiltrating
Biomarkers
Breast Neoplasms
Research
Neoplasms
Immunotherapy
Hematoxylin
Eosine Yellowish-(YS)
Pathologists
Guidelines

Keywords

  • biomarkers
  • cancer
  • immunotherapy
  • lymphocytes
  • pathology
  • tumor-infiltrating

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Assessing Tumor-infiltrating Lymphocytes in Solid Tumors : A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research. / Hendry, Shona; Salgado, Roberto; Gevaert, Thomas; Russell, Prudence A.; John, Tom; Thapa, Bibhusal; Christie, Michael; Van De Vijver, Koen; Estrada, M. V.; Gonzalez-Ericsson, Paula I.; Sanders, Melinda; Solomon, Benjamin; Solinas, Cinzia; Van Den Eynden, Gert G.G.M.; Allory, Yves; Preusser, Matthias; Hainfellner, Johannes; Pruneri, Giancarlo; Vingiani, Andrea; Demaria, Sandra; Symmans, Fraser; Nuciforo, Paolo; Comerma, Laura; Thompson, E Aubrey; Lakhani, Sunil; Kim, Seong Rim; Schnitt, Stuart; Colpaert, Cecile; Sotiriou, Christos; Scherer, Stefan J.; Ignatiadis, Michail; Badve, Sunil; Pierce, Robert H.; Viale, Giuseppe; Sirtaine, Nicolas; Penault-Llorca, Frederique; Sugie, Tomohagu; Fineberg, Susan; Paik, Soonmyung; Srinivasan, Ashok; Richardson, Andrea; Wang, Yihong; Chmielik, Ewa; Brock, Jane; Johnson, Douglas B.; Balko, Justin; Wienert, Stephan; Bossuyt, Veerle; Michiels, Stefan; Ternes, Nils; Burchardi, Nicole; Luen, Stephen J.; Savas, Peter; Klauschen, Frederick; Watson, Peter H.; Nelson, Brad H.; Criscitiello, Carmen; O'Toole, Sandra; Larsimont, Denis; De Wind, Roland; Curigliano, Giuseppe; André, Fabrice; Lacroix-Triki, Magali; Van De Vijver, Mark; Rojo, Federico; Floris, Giuseppe; Bedri, Shahinaz; Sparano, Joseph; Rimm, David; Nielsen, Torsten; Kos, Zuzana; Hewitt, Stephen; Singh, Baljit; Farshid, Gelareh; Loibl, Sibylle; Allison, Kimberly H.; Tung, Nadine; Adams, Sylvia; Willard-Gallo, Karen; Horlings, Hugo M.; Gandhi, Leena; Moreira, Andre; Hirsch, Fred; Dieci, Maria V.; Urbanowicz, Maria; Brcic, Iva; Korski, Konstanty; Gaire, Fabien; Koeppen, Hartmut; Lo, Amy; Giltnane, Jennifer; Rebelatto, Marlon C.; Steele, Keith E.; Zha, Jiping; Emancipator, Kenneth; Juco, Jonathan W.; Denkert, Carsten; Reis-Filho, Jorge; Loi, Sherene; Fox, Stephen B.

In: Advances in Anatomic Pathology, Vol. 24, No. 5, 01.01.2017, p. 235-251.

Research output: Contribution to journalReview article

Hendry, S, Salgado, R, Gevaert, T, Russell, PA, John, T, Thapa, B, Christie, M, Van De Vijver, K, Estrada, MV, Gonzalez-Ericsson, PI, Sanders, M, Solomon, B, Solinas, C, Van Den Eynden, GGGM, Allory, Y, Preusser, M, Hainfellner, J, Pruneri, G, Vingiani, A, Demaria, S, Symmans, F, Nuciforo, P, Comerma, L, Thompson, EA, Lakhani, S, Kim, SR, Schnitt, S, Colpaert, C, Sotiriou, C, Scherer, SJ, Ignatiadis, M, Badve, S, Pierce, RH, Viale, G, Sirtaine, N, Penault-Llorca, F, Sugie, T, Fineberg, S, Paik, S, Srinivasan, A, Richardson, A, Wang, Y, Chmielik, E, Brock, J, Johnson, DB, Balko, J, Wienert, S, Bossuyt, V, Michiels, S, Ternes, N, Burchardi, N, Luen, SJ, Savas, P, Klauschen, F, Watson, PH, Nelson, BH, Criscitiello, C, O'Toole, S, Larsimont, D, De Wind, R, Curigliano, G, André, F, Lacroix-Triki, M, Van De Vijver, M, Rojo, F, Floris, G, Bedri, S, Sparano, J, Rimm, D, Nielsen, T, Kos, Z, Hewitt, S, Singh, B, Farshid, G, Loibl, S, Allison, KH, Tung, N, Adams, S, Willard-Gallo, K, Horlings, HM, Gandhi, L, Moreira, A, Hirsch, F, Dieci, MV, Urbanowicz, M, Brcic, I, Korski, K, Gaire, F, Koeppen, H, Lo, A, Giltnane, J, Rebelatto, MC, Steele, KE, Zha, J, Emancipator, K, Juco, JW, Denkert, C, Reis-Filho, J, Loi, S & Fox, SB 2017, 'Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research', Advances in Anatomic Pathology, vol. 24, no. 5, pp. 235-251. https://doi.org/10.1097/PAP.0000000000000162
Hendry, Shona ; Salgado, Roberto ; Gevaert, Thomas ; Russell, Prudence A. ; John, Tom ; Thapa, Bibhusal ; Christie, Michael ; Van De Vijver, Koen ; Estrada, M. V. ; Gonzalez-Ericsson, Paula I. ; Sanders, Melinda ; Solomon, Benjamin ; Solinas, Cinzia ; Van Den Eynden, Gert G.G.M. ; Allory, Yves ; Preusser, Matthias ; Hainfellner, Johannes ; Pruneri, Giancarlo ; Vingiani, Andrea ; Demaria, Sandra ; Symmans, Fraser ; Nuciforo, Paolo ; Comerma, Laura ; Thompson, E Aubrey ; Lakhani, Sunil ; Kim, Seong Rim ; Schnitt, Stuart ; Colpaert, Cecile ; Sotiriou, Christos ; Scherer, Stefan J. ; Ignatiadis, Michail ; Badve, Sunil ; Pierce, Robert H. ; Viale, Giuseppe ; Sirtaine, Nicolas ; Penault-Llorca, Frederique ; Sugie, Tomohagu ; Fineberg, Susan ; Paik, Soonmyung ; Srinivasan, Ashok ; Richardson, Andrea ; Wang, Yihong ; Chmielik, Ewa ; Brock, Jane ; Johnson, Douglas B. ; Balko, Justin ; Wienert, Stephan ; Bossuyt, Veerle ; Michiels, Stefan ; Ternes, Nils ; Burchardi, Nicole ; Luen, Stephen J. ; Savas, Peter ; Klauschen, Frederick ; Watson, Peter H. ; Nelson, Brad H. ; Criscitiello, Carmen ; O'Toole, Sandra ; Larsimont, Denis ; De Wind, Roland ; Curigliano, Giuseppe ; André, Fabrice ; Lacroix-Triki, Magali ; Van De Vijver, Mark ; Rojo, Federico ; Floris, Giuseppe ; Bedri, Shahinaz ; Sparano, Joseph ; Rimm, David ; Nielsen, Torsten ; Kos, Zuzana ; Hewitt, Stephen ; Singh, Baljit ; Farshid, Gelareh ; Loibl, Sibylle ; Allison, Kimberly H. ; Tung, Nadine ; Adams, Sylvia ; Willard-Gallo, Karen ; Horlings, Hugo M. ; Gandhi, Leena ; Moreira, Andre ; Hirsch, Fred ; Dieci, Maria V. ; Urbanowicz, Maria ; Brcic, Iva ; Korski, Konstanty ; Gaire, Fabien ; Koeppen, Hartmut ; Lo, Amy ; Giltnane, Jennifer ; Rebelatto, Marlon C. ; Steele, Keith E. ; Zha, Jiping ; Emancipator, Kenneth ; Juco, Jonathan W. ; Denkert, Carsten ; Reis-Filho, Jorge ; Loi, Sherene ; Fox, Stephen B. / Assessing Tumor-infiltrating Lymphocytes in Solid Tumors : A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research. In: Advances in Anatomic Pathology. 2017 ; Vol. 24, No. 5. pp. 235-251.
@article{42f7b449b5fa47d09d124a76e2e08de4,
title = "Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research",
abstract = "Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy.",
keywords = "biomarkers, cancer, immunotherapy, lymphocytes, pathology, tumor-infiltrating",
author = "Shona Hendry and Roberto Salgado and Thomas Gevaert and Russell, {Prudence A.} and Tom John and Bibhusal Thapa and Michael Christie and {Van De Vijver}, Koen and Estrada, {M. V.} and Gonzalez-Ericsson, {Paula I.} and Melinda Sanders and Benjamin Solomon and Cinzia Solinas and {Van Den Eynden}, {Gert G.G.M.} and Yves Allory and Matthias Preusser and Johannes Hainfellner and Giancarlo Pruneri and Andrea Vingiani and Sandra Demaria and Fraser Symmans and Paolo Nuciforo and Laura Comerma and Thompson, {E Aubrey} and Sunil Lakhani and Kim, {Seong Rim} and Stuart Schnitt and Cecile Colpaert and Christos Sotiriou and Scherer, {Stefan J.} and Michail Ignatiadis and Sunil Badve and Pierce, {Robert H.} and Giuseppe Viale and Nicolas Sirtaine and Frederique Penault-Llorca and Tomohagu Sugie and Susan Fineberg and Soonmyung Paik and Ashok Srinivasan and Andrea Richardson and Yihong Wang and Ewa Chmielik and Jane Brock and Johnson, {Douglas B.} and Justin Balko and Stephan Wienert and Veerle Bossuyt and Stefan Michiels and Nils Ternes and Nicole Burchardi and Luen, {Stephen J.} and Peter Savas and Frederick Klauschen and Watson, {Peter H.} and Nelson, {Brad H.} and Carmen Criscitiello and Sandra O'Toole and Denis Larsimont and {De Wind}, Roland and Giuseppe Curigliano and Fabrice Andr{\'e} and Magali Lacroix-Triki and {Van De Vijver}, Mark and Federico Rojo and Giuseppe Floris and Shahinaz Bedri and Joseph Sparano and David Rimm and Torsten Nielsen and Zuzana Kos and Stephen Hewitt and Baljit Singh and Gelareh Farshid and Sibylle Loibl and Allison, {Kimberly H.} and Nadine Tung and Sylvia Adams and Karen Willard-Gallo and Horlings, {Hugo M.} and Leena Gandhi and Andre Moreira and Fred Hirsch and Dieci, {Maria V.} and Maria Urbanowicz and Iva Brcic and Konstanty Korski and Fabien Gaire and Hartmut Koeppen and Amy Lo and Jennifer Giltnane and Rebelatto, {Marlon C.} and Steele, {Keith E.} and Jiping Zha and Kenneth Emancipator and Juco, {Jonathan W.} and Carsten Denkert and Jorge Reis-Filho and Sherene Loi and Fox, {Stephen B.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1097/PAP.0000000000000162",
language = "English (US)",
volume = "24",
pages = "235--251",
journal = "Advances in Anatomic Pathology",
issn = "1072-4109",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Assessing Tumor-infiltrating Lymphocytes in Solid Tumors

T2 - A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research

AU - Hendry, Shona

AU - Salgado, Roberto

AU - Gevaert, Thomas

AU - Russell, Prudence A.

AU - John, Tom

AU - Thapa, Bibhusal

AU - Christie, Michael

AU - Van De Vijver, Koen

AU - Estrada, M. V.

AU - Gonzalez-Ericsson, Paula I.

AU - Sanders, Melinda

AU - Solomon, Benjamin

AU - Solinas, Cinzia

AU - Van Den Eynden, Gert G.G.M.

AU - Allory, Yves

AU - Preusser, Matthias

AU - Hainfellner, Johannes

AU - Pruneri, Giancarlo

AU - Vingiani, Andrea

AU - Demaria, Sandra

AU - Symmans, Fraser

AU - Nuciforo, Paolo

AU - Comerma, Laura

AU - Thompson, E Aubrey

AU - Lakhani, Sunil

AU - Kim, Seong Rim

AU - Schnitt, Stuart

AU - Colpaert, Cecile

AU - Sotiriou, Christos

AU - Scherer, Stefan J.

AU - Ignatiadis, Michail

AU - Badve, Sunil

AU - Pierce, Robert H.

AU - Viale, Giuseppe

AU - Sirtaine, Nicolas

AU - Penault-Llorca, Frederique

AU - Sugie, Tomohagu

AU - Fineberg, Susan

AU - Paik, Soonmyung

AU - Srinivasan, Ashok

AU - Richardson, Andrea

AU - Wang, Yihong

AU - Chmielik, Ewa

AU - Brock, Jane

AU - Johnson, Douglas B.

AU - Balko, Justin

AU - Wienert, Stephan

AU - Bossuyt, Veerle

AU - Michiels, Stefan

AU - Ternes, Nils

AU - Burchardi, Nicole

AU - Luen, Stephen J.

AU - Savas, Peter

AU - Klauschen, Frederick

AU - Watson, Peter H.

AU - Nelson, Brad H.

AU - Criscitiello, Carmen

AU - O'Toole, Sandra

AU - Larsimont, Denis

AU - De Wind, Roland

AU - Curigliano, Giuseppe

AU - André, Fabrice

AU - Lacroix-Triki, Magali

AU - Van De Vijver, Mark

AU - Rojo, Federico

AU - Floris, Giuseppe

AU - Bedri, Shahinaz

AU - Sparano, Joseph

AU - Rimm, David

AU - Nielsen, Torsten

AU - Kos, Zuzana

AU - Hewitt, Stephen

AU - Singh, Baljit

AU - Farshid, Gelareh

AU - Loibl, Sibylle

AU - Allison, Kimberly H.

AU - Tung, Nadine

AU - Adams, Sylvia

AU - Willard-Gallo, Karen

AU - Horlings, Hugo M.

AU - Gandhi, Leena

AU - Moreira, Andre

AU - Hirsch, Fred

AU - Dieci, Maria V.

AU - Urbanowicz, Maria

AU - Brcic, Iva

AU - Korski, Konstanty

AU - Gaire, Fabien

AU - Koeppen, Hartmut

AU - Lo, Amy

AU - Giltnane, Jennifer

AU - Rebelatto, Marlon C.

AU - Steele, Keith E.

AU - Zha, Jiping

AU - Emancipator, Kenneth

AU - Juco, Jonathan W.

AU - Denkert, Carsten

AU - Reis-Filho, Jorge

AU - Loi, Sherene

AU - Fox, Stephen B.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy.

AB - Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy.

KW - biomarkers

KW - cancer

KW - immunotherapy

KW - lymphocytes

KW - pathology

KW - tumor-infiltrating

UR - http://www.scopus.com/inward/record.url?scp=85027413331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027413331&partnerID=8YFLogxK

U2 - 10.1097/PAP.0000000000000162

DO - 10.1097/PAP.0000000000000162

M3 - Review article

C2 - 28777142

AN - SCOPUS:85027413331

VL - 24

SP - 235

EP - 251

JO - Advances in Anatomic Pathology

JF - Advances in Anatomic Pathology

SN - 1072-4109

IS - 5

ER -