Assessing the Best Surgical Template at Salvage Pelvic Lymph Node Dissection for Nodal Recurrence of Prostate Cancer After Radical Prostatectomy: When Can Bilateral Dissection be Omitted? Results from a Multi-institutional Series

Carlo A. Bravi, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Elio Mazzone, Daniele Robesti, Daniar Osmonov, Klaus Peter Juenemann, Luca Boeri, R. Jeffrey Karnes, Alexander Kretschmer, Alexander Buchner, Christian Stief, Andreas Hiester, Alessandro Nini, Peter Albers, Gaëtan Devos, Steven Joniau, Hendrik Van Poppel, Shahrokh F. ShariatAxel Heidenreich, David Pfister, Derya Tilki, Markus Graefen, Inderbir S. Gill, Alexander Mottrie, Pierre I. Karakiewicz, Francesco Montorsi, Alberto Briganti

Research output: Contribution to journalArticle

Abstract

In patients with a positron emission tomography (PET) scan suggestive of unilateral nodal recurrence from prostate cancer (PCa) after radical prostatectomy, a bilateral salvage lymph node dissection demonstrated a contralateral disease missed by imaging in approximately one of five patients. This rate varied according to the number of positive spots and PET tracer, with the lowest rate of missed PCa in men diagnosed with a single positive spot at 68Ga prostate-specific membrane antigen PET scan (6%). If replicated, our data suggest that these patients might be considered for unilateral extended pelvic salvage lymph node dissection when correct staging is considered as an endpoint.

Original languageEnglish (US)
JournalEuropean urology
DOIs
StateAccepted/In press - 2020

Keywords

  • C-choline positron emission tomography scan
  • Ga prostate-specific membrane antigen positron emission tomography scan
  • Metastasis-directed therapy
  • Neoplasm recurrence
  • Prostate cancer
  • Salvage lymph node dissection
  • Surgical template
  • Unilateral dissection

ASJC Scopus subject areas

  • Urology

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    Bravi, C. A., Fossati, N., Gandaglia, G., Suardi, N., Mazzone, E., Robesti, D., Osmonov, D., Juenemann, K. P., Boeri, L., Jeffrey Karnes, R., Kretschmer, A., Buchner, A., Stief, C., Hiester, A., Nini, A., Albers, P., Devos, G., Joniau, S., Van Poppel, H., ... Briganti, A. (Accepted/In press). Assessing the Best Surgical Template at Salvage Pelvic Lymph Node Dissection for Nodal Recurrence of Prostate Cancer After Radical Prostatectomy: When Can Bilateral Dissection be Omitted? Results from a Multi-institutional Series. European urology. https://doi.org/10.1016/j.eururo.2020.06.047