Abstract
Efforts to characterize stakeholder attitudes about the implementation of genomic medicine would benefit from a validated instrument for measuring public views of the potential benefits and harms of genomic technologies, which would facilitate comparison across populations and clinical settings. We sought to develop a scale to evaluate attitudes about the future of genomic medicine. We developed a 21-item scale that examined the likelihood of various outcomes of genomic medicine. The scale was administered to participants in a genomic sequencing study. Exploratory factor analysis was conducted and bivariate correlations were calculated. The genomic orientation (GO) scale was completed by 2895 participants. A two-factor structure was identified, corresponding to an optimism subscale (16 items, α = 0.89) and a pessimism subscale (5 items, α = 0.63). Genomic optimism was positively associated with a perceived value of genetic test results, higher health literacy, and decreased decisional conflict about participation in a genomic research study. Genomic pessimism was associated with concerns about genetic testing, lower health literacy, and increased decisional conflict about the decision to participate in the study. The GO scale is a promising tool for measuring both positive and negative views regarding the future of genomic medicine and deserves further validation.
| Original language | English (US) |
|---|---|
| Journal | Clinical Genetics |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- attitudes
- factor analysis
- genetic testing
- genomics
- optimism
- pessimism
- statistical
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
Cite this
Assessing optimism and pessimism about genomic medicine : Development of a genomic orientation scale. / Horrow, Caroline; Pacyna, Joel E.; Sutton, Erica J.; Sperry, Beau P.; Radecki Breitkopf, Carmen; Sharp, Richard R.
In: Clinical Genetics, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessing optimism and pessimism about genomic medicine
T2 - Development of a genomic orientation scale
AU - Horrow, Caroline
AU - Pacyna, Joel E.
AU - Sutton, Erica J.
AU - Sperry, Beau P.
AU - Radecki Breitkopf, Carmen
AU - Sharp, Richard R
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Efforts to characterize stakeholder attitudes about the implementation of genomic medicine would benefit from a validated instrument for measuring public views of the potential benefits and harms of genomic technologies, which would facilitate comparison across populations and clinical settings. We sought to develop a scale to evaluate attitudes about the future of genomic medicine. We developed a 21-item scale that examined the likelihood of various outcomes of genomic medicine. The scale was administered to participants in a genomic sequencing study. Exploratory factor analysis was conducted and bivariate correlations were calculated. The genomic orientation (GO) scale was completed by 2895 participants. A two-factor structure was identified, corresponding to an optimism subscale (16 items, α = 0.89) and a pessimism subscale (5 items, α = 0.63). Genomic optimism was positively associated with a perceived value of genetic test results, higher health literacy, and decreased decisional conflict about participation in a genomic research study. Genomic pessimism was associated with concerns about genetic testing, lower health literacy, and increased decisional conflict about the decision to participate in the study. The GO scale is a promising tool for measuring both positive and negative views regarding the future of genomic medicine and deserves further validation.
AB - Efforts to characterize stakeholder attitudes about the implementation of genomic medicine would benefit from a validated instrument for measuring public views of the potential benefits and harms of genomic technologies, which would facilitate comparison across populations and clinical settings. We sought to develop a scale to evaluate attitudes about the future of genomic medicine. We developed a 21-item scale that examined the likelihood of various outcomes of genomic medicine. The scale was administered to participants in a genomic sequencing study. Exploratory factor analysis was conducted and bivariate correlations were calculated. The genomic orientation (GO) scale was completed by 2895 participants. A two-factor structure was identified, corresponding to an optimism subscale (16 items, α = 0.89) and a pessimism subscale (5 items, α = 0.63). Genomic optimism was positively associated with a perceived value of genetic test results, higher health literacy, and decreased decisional conflict about participation in a genomic research study. Genomic pessimism was associated with concerns about genetic testing, lower health literacy, and increased decisional conflict about the decision to participate in the study. The GO scale is a promising tool for measuring both positive and negative views regarding the future of genomic medicine and deserves further validation.
KW - attitudes
KW - factor analysis
KW - genetic testing
KW - genomics
KW - optimism
KW - pessimism
KW - statistical
UR - http://www.scopus.com/inward/record.url?scp=85063779021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063779021&partnerID=8YFLogxK
U2 - 10.1111/cge.13535
DO - 10.1111/cge.13535
M3 - Article
C2 - 30868559
AN - SCOPUS:85063779021
JO - Clinical Genetics
JF - Clinical Genetics
SN - 0009-9163
ER -