Assessing Near-Infrared Quantum Dots for Deep Tissue, Organ, and Animal Imaging Applications

Wen Jiang, Anupam Singhal, Y S Betty Kim, Jianing Zheng, James T. Rutka, Chen Wang, Warren C W Chan

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Semiconductor quantum dots (Qdots) have emerged as novel ultrasensitive optical probes to target, detect, and image fundamental events occurring within the biological system. In particular, near-infrared (near-IR) Qdots holds great promise as in vivo contrast agents for real-time bioimaging capabilities. In this study, biocompatible near-IR Qdots are used to image organs, tissues, and cells. Compared to visible Qdots, we obtained a significant enhancement in signal detection sensitivity for imaging deep tissues and organs. In addition, biomolecules were used to target these optical contrast agents for multiplexed imaging of cells and organs in vivo. The ability to simultaneously distinguish emission profiles of multiple near-IR Qdots will likely emerge as important tools for addressing fundamental questions in molecular biology and in medical sciences.

Original languageEnglish (US)
Pages (from-to)6-12
Number of pages7
JournalJALA - Journal of the Association for Laboratory Automation
Volume13
Issue number1
DOIs
StatePublished - Feb 2008
Externally publishedYes

Fingerprint

Animal Structures
Quantum Dots
Semiconductor quantum dots
Animals
Tissue
Infrared radiation
Imaging techniques
Contrast Media
Semiconductors
Molecular biology
Signal detection
Biomolecules
Biological systems
Molecular Biology

Keywords

  • animal
  • in vivo imaging
  • multiplexed imaging
  • near-infrared imaging
  • optical imaging
  • organ
  • quantum dots
  • targeting

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Biotechnology

Cite this

Assessing Near-Infrared Quantum Dots for Deep Tissue, Organ, and Animal Imaging Applications. / Jiang, Wen; Singhal, Anupam; Kim, Y S Betty; Zheng, Jianing; Rutka, James T.; Wang, Chen; Chan, Warren C W.

In: JALA - Journal of the Association for Laboratory Automation, Vol. 13, No. 1, 02.2008, p. 6-12.

Research output: Contribution to journalArticle

Jiang, Wen ; Singhal, Anupam ; Kim, Y S Betty ; Zheng, Jianing ; Rutka, James T. ; Wang, Chen ; Chan, Warren C W. / Assessing Near-Infrared Quantum Dots for Deep Tissue, Organ, and Animal Imaging Applications. In: JALA - Journal of the Association for Laboratory Automation. 2008 ; Vol. 13, No. 1. pp. 6-12.
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