Assessing linkage on chromosome 5 using components of variance approach

Univariate versus multivariate

Mariza De Andrade, T. J. Thiel, LiPing P. Yu, C. I. Amos

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We report when one disease related quantitative trait (Q1) is analyzed versus multiple related quantitative traits using a components of variance approach [Amos, 1994; de Andrade and Amos, 1996]. In both cases, we used age, sex and environmental factor (EF) as covariates. Analysis with ascertainment correction of samples selected through probands with extremely high trait values was also performed and is presented. Testing procedures to detect linkage using the components of variance approach are discussed. The univariate and multivariate analyses showed effects of locus 15 on chromosome 5 only for Q1. This result was confirmed when using ascertainment correction.

Original languageEnglish (US)
Pages (from-to)773-778
Number of pages6
JournalGenetic Epidemiology
Volume14
Issue number6
DOIs
StatePublished - 1997
Externally publishedYes

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Sex Factors
Chromosomes, Human, Pair 5
Multivariate Analysis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Assessing linkage on chromosome 5 using components of variance approach : Univariate versus multivariate. / De Andrade, Mariza; Thiel, T. J.; Yu, LiPing P.; Amos, C. I.

In: Genetic Epidemiology, Vol. 14, No. 6, 1997, p. 773-778.

Research output: Contribution to journalArticle

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