Assessing linkage on chromosome 5 using components of variance approach: Univariate versus multivariate

Mariza De Andrade, T. J. Thiel, LiPing P. Yu, C. I. Amos

Research output: Contribution to journalArticle

30 Scopus citations


We report when one disease related quantitative trait (Q1) is analyzed versus multiple related quantitative traits using a components of variance approach [Amos, 1994; de Andrade and Amos, 1996]. In both cases, we used age, sex and environmental factor (EF) as covariates. Analysis with ascertainment correction of samples selected through probands with extremely high trait values was also performed and is presented. Testing procedures to detect linkage using the components of variance approach are discussed. The univariate and multivariate analyses showed effects of locus 15 on chromosome 5 only for Q1. This result was confirmed when using ascertainment correction.

Original languageEnglish (US)
Pages (from-to)773-778
Number of pages6
JournalGenetic Epidemiology
Issue number6
StatePublished - 1997
Externally publishedYes


ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

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