A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions

Vincent W. Vanek, Douglas L. Seidner, Penny Allen, Bruce Bistrian, Sharon Collier, Kathleen Gura, John M. Miles, Christina J. Valentine, Marty Kochevar

Research output: Contribution to journalArticle

112 Scopus citations


The currently available, standard soybean oil (SO)-based intravenous fat emulsions (IVFEs) meet the needs of most parenteral nutrition (PN) patients. There are alternative oil-based fat emulsions, such as medium-chain triglycerides (MCTs), olive oils (OOs), and fish oils (FOs), that, based on extensive usage in Europe, have an equivalent safety profile to SO. These alternative IVFEs are metabolized via different pathways, which may lead to less proinflammatory effects and less immune suppression. These alternative oil-based IVFEs are not currently available in the United States. Many patients who require IVFEs are already in a compromised state. Such patients could potentially have better clinical outcomes when receiving one of the alternative IVFEs to diminish the intake of the potentially proinflammatory ω-6 fatty acid-linoleic acid-which comprises more than 50% of the fatty acid profile in SO. Further research is needed on these alternative oil-based IVFEs to identify which IVFE oils or which combination of oils may be most clinically useful for specific patient populations.

Original languageEnglish (US)
Pages (from-to)150-192
Number of pages43
JournalNutrition in Clinical Practice
Issue number2
StatePublished - Apr 1 2012



  • fat emulsions
  • fatty acids, omega-3
  • fatty acids, omega-6
  • lipids
  • parenteral nutrition
  • parenteral nutrition solutions

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Vanek, V. W., Seidner, D. L., Allen, P., Bistrian, B., Collier, S., Gura, K., Miles, J. M., Valentine, C. J., & Kochevar, M. (2012). A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions. Nutrition in Clinical Practice, 27(2), 150-192. https://doi.org/10.1177/0884533612439896