Aspartate mutations in presenilin and γ-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch1 signaling
Oksana Berezovska, Christine Jack, Pamela McLean, Jon C. Aster, Carol Hicks, Weiming Xia, Michael S. Wolfe, W. Taylor Kimberly, Gerry Weinmaster, Dennis J. Selkoe, Bradley T. Hyman
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