Ascorbic acid and α-tocopherol as potent modulators on arsenic induced toxicity in mitochondria

Kadirvel Ramanathan, Samuel Shila, Sundaram Kumaran, Chinnakkannu Panneerselvam

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Arsenic exists ubiquitously in our environment and various forms of arsenic circulate in air, water, soil and living organisms. Since arsenic compounds have shown to exert their toxicity chiefly by generating reactive oxygen species, we have evaluated the effect of antioxidants ascorbic acid and α-tocopherol on lipid peroxidation, antioxidants and mitochondrial enzymes in liver and kidney of arsenic exposed rats. A significant increase in the level of lipid peroxidation and decrease in the levels of antioxidants and in the activities of mitochondrial enzymes were observed in arsenic intoxicated rats. Co-administration of arsenic treated rats with ascorbic acid and α-tocopherol showed significant reduction in the level of lipid peroxidation and elevation in the levels of ascorbic acid, α-tocopherol, glutathione and total sulfhydryls and in the activities of isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, NADH-dehydrogenase and cytochrome c oxidase. From our results, we conclude that ascorbic acid and α-tocopherol alleviate arsenic-induced alterations in mitochondria.

Original languageEnglish (US)
Pages (from-to)416-420
Number of pages5
JournalJournal of Nutritional Biochemistry
Volume14
Issue number7
DOIs
StatePublished - Jul 1 2003

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

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