Ascorbic acid and α-tocopherol as potent modulators on arsenic induced toxicity in mitochondria

Ramanathan D Kadirvel, Samuel Shila, Sundaram Kumaran, Chinnakkannu Panneerselvam

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Arsenic exists ubiquitously in our environment and various forms of arsenic circulate in air, water, soil and living organisms. Since arsenic compounds have shown to exert their toxicity chiefly by generating reactive oxygen species, we have evaluated the effect of antioxidants ascorbic acid and α-tocopherol on lipid peroxidation, antioxidants and mitochondrial enzymes in liver and kidney of arsenic exposed rats. A significant increase in the level of lipid peroxidation and decrease in the levels of antioxidants and in the activities of mitochondrial enzymes were observed in arsenic intoxicated rats. Co-administration of arsenic treated rats with ascorbic acid and α-tocopherol showed significant reduction in the level of lipid peroxidation and elevation in the levels of ascorbic acid, α-tocopherol, glutathione and total sulfhydryls and in the activities of isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, NADH-dehydrogenase and cytochrome c oxidase. From our results, we conclude that ascorbic acid and α-tocopherol alleviate arsenic-induced alterations in mitochondria.

Original languageEnglish (US)
Pages (from-to)416-420
Number of pages5
JournalJournal of Nutritional Biochemistry
Volume14
Issue number7
DOIs
StatePublished - Jul 1 2003
Externally publishedYes

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Mitochondria
Tocopherols
Arsenic
Modulators
Ascorbic Acid
Toxicity
Lipid Peroxidation
Rats
Antioxidants
Lipids
Arsenicals
Isocitrate Dehydrogenase
NADH Dehydrogenase
Succinate Dehydrogenase
Electron Transport Complex IV
Enzymes
Liver
Glutathione
Reactive Oxygen Species
Oxidoreductases

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Ascorbic acid and α-tocopherol as potent modulators on arsenic induced toxicity in mitochondria. / Kadirvel, Ramanathan D; Shila, Samuel; Kumaran, Sundaram; Panneerselvam, Chinnakkannu.

In: Journal of Nutritional Biochemistry, Vol. 14, No. 7, 01.07.2003, p. 416-420.

Research output: Contribution to journalArticle

Kadirvel, Ramanathan D ; Shila, Samuel ; Kumaran, Sundaram ; Panneerselvam, Chinnakkannu. / Ascorbic acid and α-tocopherol as potent modulators on arsenic induced toxicity in mitochondria. In: Journal of Nutritional Biochemistry. 2003 ; Vol. 14, No. 7. pp. 416-420.
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