Ascending the learning curve-MSI testing experience of a six-laboratory consortium

Noralane M. Lindor; Regenia Smalley; Melissa Barker; Jeannette Bigler; Lisa M. Krumroy; Annette Lum-Jones; Sarah J. Plummer; Teresa Selander; Sushma Thomas; Michelle Youash; Daniela Seminara; Graham Casey; Bharati Bapat; Stephen N. Thibodeau

doi:10.3233/CBM-2006-21-202

Ascending the learning curve-MSI testing experience of a six-laboratory consortium

Noralane M. Lindor, Regenia Smalley, Melissa Barker, Jeannette Bigler, Lisa M. Krumroy, Annette Lum-Jones, Sarah J. Plummer, Teresa Selander, Sushma Thomas, Michelle Youash, Daniela Seminara, Graham Casey, Bharati Bapat, Stephen N. Thibodeau

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

According to recently published guidelines, microsatellite instability (MSI) testing of colorectal cancers may be clinically indicated on a significant proportion of all colorectal tumors. To date, nothing has been published regarding the reproducibility of MSI testing between laboratories. We present MSI quality control activities experience of a six center multinational consortium, as laboratories developed competency with MSI testing and interpretation. The aim of this paper is to share lessons learned and to describe the final concordance rates in scoring MSI markers within this consortium.

Original language	English (US)
Pages (from-to)	5-9
Number of pages	5
Journal	Cancer Biomarkers
Volume	2
Issue number	1-2
DOIs	https://doi.org/10.3233/CBM-2006-21-202
State	Published - 2006

ASJC Scopus subject areas

Genetics
Oncology
Cancer Research

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title = "Ascending the learning curve-MSI testing experience of a six-laboratory consortium",

abstract = "According to recently published guidelines, microsatellite instability (MSI) testing of colorectal cancers may be clinically indicated on a significant proportion of all colorectal tumors. To date, nothing has been published regarding the reproducibility of MSI testing between laboratories. We present MSI quality control activities experience of a six center multinational consortium, as laboratories developed competency with MSI testing and interpretation. The aim of this paper is to share lessons learned and to describe the final concordance rates in scoring MSI markers within this consortium.",

author = "Lindor, {Noralane M.} and Regenia Smalley and Melissa Barker and Jeannette Bigler and Krumroy, {Lisa M.} and Annette Lum-Jones and Plummer, {Sarah J.} and Teresa Selander and Sushma Thomas and Michelle Youash and Daniela Seminara and Graham Casey and Bharati Bapat and Thibodeau, {Stephen N.}",

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doi = "10.3233/CBM-2006-21-202",

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T1 - Ascending the learning curve-MSI testing experience of a six-laboratory consortium

AU - Lindor, Noralane M.

AU - Smalley, Regenia

AU - Barker, Melissa

AU - Bigler, Jeannette

AU - Krumroy, Lisa M.

AU - Lum-Jones, Annette

AU - Plummer, Sarah J.

AU - Selander, Teresa

AU - Thomas, Sushma

AU - Youash, Michelle

AU - Seminara, Daniela

AU - Casey, Graham

AU - Bapat, Bharati

AU - Thibodeau, Stephen N.

PY - 2006

Y1 - 2006

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AB - According to recently published guidelines, microsatellite instability (MSI) testing of colorectal cancers may be clinically indicated on a significant proportion of all colorectal tumors. To date, nothing has been published regarding the reproducibility of MSI testing between laboratories. We present MSI quality control activities experience of a six center multinational consortium, as laboratories developed competency with MSI testing and interpretation. The aim of this paper is to share lessons learned and to describe the final concordance rates in scoring MSI markers within this consortium.

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Ascending the learning curve-MSI testing experience of a six-laboratory consortium

Abstract

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