Ascending the learning curve-MSI testing experience of a six-laboratory consortium

Noralane M. Lindor, Regenia Smalley, Melissa Barker, Jeannette Bigler, Lisa M. Krumroy, Annette Lum-Jones, Sarah J. Plummer, Teresa Selander, Sushma Thomas, Michelle Youash, Daniela Seminara, Graham Casey, Bharati Bapat, Stephen N. Thibodeau

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

According to recently published guidelines, microsatellite instability (MSI) testing of colorectal cancers may be clinically indicated on a significant proportion of all colorectal tumors. To date, nothing has been published regarding the reproducibility of MSI testing between laboratories. We present MSI quality control activities experience of a six center multinational consortium, as laboratories developed competency with MSI testing and interpretation. The aim of this paper is to share lessons learned and to describe the final concordance rates in scoring MSI markers within this consortium.

Original languageEnglish (US)
Pages (from-to)5-9
Number of pages5
JournalCancer Biomarkers
Volume2
Issue number1-2
DOIs
StatePublished - 2006

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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    Lindor, N. M., Smalley, R., Barker, M., Bigler, J., Krumroy, L. M., Lum-Jones, A., Plummer, S. J., Selander, T., Thomas, S., Youash, M., Seminara, D., Casey, G., Bapat, B., & Thibodeau, S. N. (2006). Ascending the learning curve-MSI testing experience of a six-laboratory consortium. Cancer Biomarkers, 2(1-2), 5-9. https://doi.org/10.3233/CBM-2006-21-202