ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer

Laura Cato, Jonas de Tribolet-Hardy, Irene Lee, Jaice T. Rottenberg, Ilsa Coleman, Diana Melchers, René Houtman, Tengfei Xiao, Wei Li, Takuma Uo, Shihua Sun, Nane C. Kuznik, Bettina Göppert, Fatma Ozgun, Martin E. van Royen, Adriaan B. Houtsmuller, Raga Vadhi, Prakash K. Rao, Lewyn Li, Steven P. Balk & 15 others Robert B. Den, Bruce J. Trock, Robert Jeffrey Karnes, Robert Brian Jenkins, Eric A. Klein, Elai Davicioni, Friederike J. Gruhl, Henry W. Long, X. Shirley Liu, Andrew C.B. Cato, Nathan A. Lack, Peter S. Nelson, Stephen R. Plymate, Anna C. Groner, Myles Brown

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cato et al. utilize cistrome and transcriptome analyses in castration-resistant prostate cancer (CRPC) to reveal that the androgen receptor (AR) splice variant ARv7 functions as a transcriptional repressor and heterodimerizes with full-length AR at a subset of growth-suppressive genes to support CRPC growth.

Original languageEnglish (US)
Pages (from-to)401-413.e6
JournalCancer cell
Volume35
Issue number3
DOIs
StatePublished - Mar 18 2019

Fingerprint

Castration
Androgen Receptors
Tumor Suppressor Genes
Prostatic Neoplasms
Gene Expression Profiling
Growth
Genes

Keywords

  • androgen receptor (AR)
  • AR variant v7 (ARv7)
  • castration-resistant prostate cancer (CRPC)
  • transcription

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Cato, L., de Tribolet-Hardy, J., Lee, I., Rottenberg, J. T., Coleman, I., Melchers, D., ... Brown, M. (2019). ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. Cancer cell, 35(3), 401-413.e6. https://doi.org/10.1016/j.ccell.2019.01.008

ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. / Cato, Laura; de Tribolet-Hardy, Jonas; Lee, Irene; Rottenberg, Jaice T.; Coleman, Ilsa; Melchers, Diana; Houtman, René; Xiao, Tengfei; Li, Wei; Uo, Takuma; Sun, Shihua; Kuznik, Nane C.; Göppert, Bettina; Ozgun, Fatma; van Royen, Martin E.; Houtsmuller, Adriaan B.; Vadhi, Raga; Rao, Prakash K.; Li, Lewyn; Balk, Steven P.; Den, Robert B.; Trock, Bruce J.; Karnes, Robert Jeffrey; Jenkins, Robert Brian; Klein, Eric A.; Davicioni, Elai; Gruhl, Friederike J.; Long, Henry W.; Liu, X. Shirley; Cato, Andrew C.B.; Lack, Nathan A.; Nelson, Peter S.; Plymate, Stephen R.; Groner, Anna C.; Brown, Myles.

In: Cancer cell, Vol. 35, No. 3, 18.03.2019, p. 401-413.e6.

Research output: Contribution to journalArticle

Cato, L, de Tribolet-Hardy, J, Lee, I, Rottenberg, JT, Coleman, I, Melchers, D, Houtman, R, Xiao, T, Li, W, Uo, T, Sun, S, Kuznik, NC, Göppert, B, Ozgun, F, van Royen, ME, Houtsmuller, AB, Vadhi, R, Rao, PK, Li, L, Balk, SP, Den, RB, Trock, BJ, Karnes, RJ, Jenkins, RB, Klein, EA, Davicioni, E, Gruhl, FJ, Long, HW, Liu, XS, Cato, ACB, Lack, NA, Nelson, PS, Plymate, SR, Groner, AC & Brown, M 2019, 'ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer', Cancer cell, vol. 35, no. 3, pp. 401-413.e6. https://doi.org/10.1016/j.ccell.2019.01.008
Cato L, de Tribolet-Hardy J, Lee I, Rottenberg JT, Coleman I, Melchers D et al. ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. Cancer cell. 2019 Mar 18;35(3):401-413.e6. https://doi.org/10.1016/j.ccell.2019.01.008
Cato, Laura ; de Tribolet-Hardy, Jonas ; Lee, Irene ; Rottenberg, Jaice T. ; Coleman, Ilsa ; Melchers, Diana ; Houtman, René ; Xiao, Tengfei ; Li, Wei ; Uo, Takuma ; Sun, Shihua ; Kuznik, Nane C. ; Göppert, Bettina ; Ozgun, Fatma ; van Royen, Martin E. ; Houtsmuller, Adriaan B. ; Vadhi, Raga ; Rao, Prakash K. ; Li, Lewyn ; Balk, Steven P. ; Den, Robert B. ; Trock, Bruce J. ; Karnes, Robert Jeffrey ; Jenkins, Robert Brian ; Klein, Eric A. ; Davicioni, Elai ; Gruhl, Friederike J. ; Long, Henry W. ; Liu, X. Shirley ; Cato, Andrew C.B. ; Lack, Nathan A. ; Nelson, Peter S. ; Plymate, Stephen R. ; Groner, Anna C. ; Brown, Myles. / ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. In: Cancer cell. 2019 ; Vol. 35, No. 3. pp. 401-413.e6.
@article{e767fb50228540f495cd60a3cf73019d,
title = "ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer",
abstract = "Cato et al. utilize cistrome and transcriptome analyses in castration-resistant prostate cancer (CRPC) to reveal that the androgen receptor (AR) splice variant ARv7 functions as a transcriptional repressor and heterodimerizes with full-length AR at a subset of growth-suppressive genes to support CRPC growth.",
keywords = "androgen receptor (AR), AR variant v7 (ARv7), castration-resistant prostate cancer (CRPC), transcription",
author = "Laura Cato and {de Tribolet-Hardy}, Jonas and Irene Lee and Rottenberg, {Jaice T.} and Ilsa Coleman and Diana Melchers and Ren{\'e} Houtman and Tengfei Xiao and Wei Li and Takuma Uo and Shihua Sun and Kuznik, {Nane C.} and Bettina G{\"o}ppert and Fatma Ozgun and {van Royen}, {Martin E.} and Houtsmuller, {Adriaan B.} and Raga Vadhi and Rao, {Prakash K.} and Lewyn Li and Balk, {Steven P.} and Den, {Robert B.} and Trock, {Bruce J.} and Karnes, {Robert Jeffrey} and Jenkins, {Robert Brian} and Klein, {Eric A.} and Elai Davicioni and Gruhl, {Friederike J.} and Long, {Henry W.} and Liu, {X. Shirley} and Cato, {Andrew C.B.} and Lack, {Nathan A.} and Nelson, {Peter S.} and Plymate, {Stephen R.} and Groner, {Anna C.} and Myles Brown",
year = "2019",
month = "3",
day = "18",
doi = "10.1016/j.ccell.2019.01.008",
language = "English (US)",
volume = "35",
pages = "401--413.e6",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer

AU - Cato, Laura

AU - de Tribolet-Hardy, Jonas

AU - Lee, Irene

AU - Rottenberg, Jaice T.

AU - Coleman, Ilsa

AU - Melchers, Diana

AU - Houtman, René

AU - Xiao, Tengfei

AU - Li, Wei

AU - Uo, Takuma

AU - Sun, Shihua

AU - Kuznik, Nane C.

AU - Göppert, Bettina

AU - Ozgun, Fatma

AU - van Royen, Martin E.

AU - Houtsmuller, Adriaan B.

AU - Vadhi, Raga

AU - Rao, Prakash K.

AU - Li, Lewyn

AU - Balk, Steven P.

AU - Den, Robert B.

AU - Trock, Bruce J.

AU - Karnes, Robert Jeffrey

AU - Jenkins, Robert Brian

AU - Klein, Eric A.

AU - Davicioni, Elai

AU - Gruhl, Friederike J.

AU - Long, Henry W.

AU - Liu, X. Shirley

AU - Cato, Andrew C.B.

AU - Lack, Nathan A.

AU - Nelson, Peter S.

AU - Plymate, Stephen R.

AU - Groner, Anna C.

AU - Brown, Myles

PY - 2019/3/18

Y1 - 2019/3/18

N2 - Cato et al. utilize cistrome and transcriptome analyses in castration-resistant prostate cancer (CRPC) to reveal that the androgen receptor (AR) splice variant ARv7 functions as a transcriptional repressor and heterodimerizes with full-length AR at a subset of growth-suppressive genes to support CRPC growth.

AB - Cato et al. utilize cistrome and transcriptome analyses in castration-resistant prostate cancer (CRPC) to reveal that the androgen receptor (AR) splice variant ARv7 functions as a transcriptional repressor and heterodimerizes with full-length AR at a subset of growth-suppressive genes to support CRPC growth.

KW - androgen receptor (AR)

KW - AR variant v7 (ARv7)

KW - castration-resistant prostate cancer (CRPC)

KW - transcription

UR - http://www.scopus.com/inward/record.url?scp=85062639270&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062639270&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2019.01.008

DO - 10.1016/j.ccell.2019.01.008

M3 - Article

VL - 35

SP - 401-413.e6

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 3

ER -