Artificial and bioartificial liver support

Travis J. McKenzie, Joseph B. Lillegard, Scott Nyberg

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

Acute liver failure (ALF) is a widespread problem with an unfavorable prognosis. Currently, liver transplantation is the only direct means of treatment for patients in ALF. Due to the scarcity of donor organs, liver support technologies are being developed and clinically tested with the intent of supporting a patient in ALF until the patient regains native liver function or until a donor organ becomes available. Two major categories of devices are currently being tested. Artificial liver support is purely mechanical, including albumin dialysis. Bioartificial devices contain cellular material. No single system has reproducibly demonstrated improvement in patient mortality. However, with the advent of new technology and cell acquisition techniques, further randomized controlled trials will be necessary to determine the role of artificial and bioartificial liver support devices in the treatment of patients with ALF.

Original languageEnglish (US)
Pages (from-to)210-217
Number of pages8
JournalSeminars in Liver Disease
Volume28
Issue number2
DOIs
StatePublished - May 1 2008

Fingerprint

Artificial Liver
Acute Liver Failure
Equipment and Supplies
Tissue Donors
Technology
Liver
Liver Transplantation
Dialysis
Albumins
Randomized Controlled Trials
Mortality
Therapeutics

Keywords

  • Acute liver failure
  • Artificial liver
  • Bioartificial liver
  • Liver support device

ASJC Scopus subject areas

  • Hepatology

Cite this

Artificial and bioartificial liver support. / McKenzie, Travis J.; Lillegard, Joseph B.; Nyberg, Scott.

In: Seminars in Liver Disease, Vol. 28, No. 2, 01.05.2008, p. 210-217.

Research output: Contribution to journalReview article

McKenzie, Travis J. ; Lillegard, Joseph B. ; Nyberg, Scott. / Artificial and bioartificial liver support. In: Seminars in Liver Disease. 2008 ; Vol. 28, No. 2. pp. 210-217.
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