Artery length sensitivity in patient-specific cerebral aneurysm simulations

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Abstract

BACKGROUND AND PURPOSE: The reconstruction of aneurysm geometry is a main factor affecting the accuracy of hemodynamics simulations in patient-specific aneurysms. We analyzed the effects of the inlet artery length on intra-aneurysmal flow estimations by using 10 ophthalmic aneurysm models. MATERIALS AND METHODS: We successively truncated the inlet artery of each model, first at the cavernous segment and second at the clinoid segment. For each aneurysm, we obtained 3 models with different artery lengths: the originally segmented geometry with the longest available inletfrom scans and 2 others with successively shorter artery lengths. We analyzed the velocity, wall shear stress, and the oscillatory shear index inside the aneurysm and compared the 2 truncations with the original model. RESULTS: We found that eliminating 1 arterial turn resulted in root mean square errors of <18% with no visual differences for the contours of the flow parameters in 8 of the 10 models. In contrast, truncating at the second turn led to root mean square errors between 18% and 32%, with consistently large errors for wall shear stress and the oscillatory shear index in 5 of the 10 models and visual differences for the contours of the flow parameters. For 3 other models, the largest errors were between 43% and 55%, with large visual differences in the contour plots. CONCLUSIONS: Excluding 2 arterial turns from the inlet artery length of the ophthalmic aneurysm resulted in large quantitative differences in the calculated velocity, wall shear stress, and oscillatory shear index distributions, which could lead to erroneous conclusions if used clinically.

Original languageEnglish (US)
Pages (from-to)737-743
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume36
Issue number4
DOIs
StatePublished - Apr 1 2015

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Intracranial Aneurysm
Aneurysm
Arteries
Patient Simulation
Ophthalmic Artery
Hemodynamics

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

Artery length sensitivity in patient-specific cerebral aneurysm simulations. / Hodis, S.; Kargar, S.; Kallmes, David F; Dragomir Daescu, M. (Dan).

In: American Journal of Neuroradiology, Vol. 36, No. 4, 01.04.2015, p. 737-743.

Research output: Contribution to journalArticle

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abstract = "BACKGROUND AND PURPOSE: The reconstruction of aneurysm geometry is a main factor affecting the accuracy of hemodynamics simulations in patient-specific aneurysms. We analyzed the effects of the inlet artery length on intra-aneurysmal flow estimations by using 10 ophthalmic aneurysm models. MATERIALS AND METHODS: We successively truncated the inlet artery of each model, first at the cavernous segment and second at the clinoid segment. For each aneurysm, we obtained 3 models with different artery lengths: the originally segmented geometry with the longest available inletfrom scans and 2 others with successively shorter artery lengths. We analyzed the velocity, wall shear stress, and the oscillatory shear index inside the aneurysm and compared the 2 truncations with the original model. RESULTS: We found that eliminating 1 arterial turn resulted in root mean square errors of <18{\%} with no visual differences for the contours of the flow parameters in 8 of the 10 models. In contrast, truncating at the second turn led to root mean square errors between 18{\%} and 32{\%}, with consistently large errors for wall shear stress and the oscillatory shear index in 5 of the 10 models and visual differences for the contours of the flow parameters. For 3 other models, the largest errors were between 43{\%} and 55{\%}, with large visual differences in the contour plots. CONCLUSIONS: Excluding 2 arterial turns from the inlet artery length of the ophthalmic aneurysm resulted in large quantitative differences in the calculated velocity, wall shear stress, and oscillatory shear index distributions, which could lead to erroneous conclusions if used clinically.",
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